STAA3:SAER

Species (Taxon ID)	Staphylococcus aureus (strain USA300). (367830)
Gene Name(s)	saeR
Protein Name(s)	Response regulator SaeR Staphylococcus exoprotein expression protein R
External Links
UniProt	Q2FIT4
EMBL	CP000255
RefSeq	YP_493394.1
ProteinModelPortal	Q2FIT4
SMR	Q2FIT4
STRING	451515.SAUSA300_0691
EnsemblBacteria	ABD22784
GeneID	3913605
KEGG	saa:SAUSA300_0691
PATRIC	19590673
eggNOG	COG0745
HOGENOM	HOG000034819
KO	K10682
OMA	KDYLAMN
OrthoDB	EOG6G4VQG
BioCyc	SAUR451515:GH3C-691-MONOMER
Proteomes	UP000001939
GO	GO:0005737 GO:0003677 GO:0009405 GO:0000160 GO:0006355 GO:0006351
Gene3D	1.10.10.10
InterPro	IPR011006 IPR001867 IPR001789 IPR011991
Pfam	PF00072 PF00486
SMART	SM00448 SM00862
SUPFAM	SSF52172
PROSITE	PS50110

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0009405	pathogenesis	PMID:20001858	ECO:0000315			P		saeR is part of a two component system saeR/S in Staphylococcus aureus that performs many functions. Among those functions, saeRS aids in pathogenesis by increasing the virulence. In this experiment, the USA300 strain, both a wt and a deltasaeRS, were injected into mice. The researchers recorded the process of the infection, to see if there was a difference between the wild type and mutant strains. Referring to Figure 2B, only a certain percentage [about 50%] of the mice that were injected became infected versus 100% of the wild type strain. Also, none of the mice that had the mutant strain resulted in necrosis of the skin. In figure 2E, the mouse survival percentanges were significantly higher in the mutant strain than in the wild type strain, meaning that with the deletion, it took a lot longer for the infection to become lethal to some of the mice that were infected. Furthermore, based on this evidence, I believe that the saeR/S system functions to help increase the virulence of the Staphylococcus aureus USA 300 strain.	complete
involved_in	GO:0000160	phosphorelay signal transduction system	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001789 InterPro:IPR001867	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001867	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001867	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0009405	pathogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0843	P		Seeded From UniProt	complete
involved_in	GO:0000160	phosphorelay signal transduction system	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0902	P		Seeded From UniProt	complete
involved_in	GO:0050896	response to stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0716	P		Seeded From UniProt	complete
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References

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