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SHIFL:OSPF

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Species (Taxon ID) Shigella flexneri. (623)
Gene Name(s) ospF (synonyms: mkaD)
Protein Name(s) Phosphothreonine lyase OspF

Effector protein OspF

External Links
UniProt Q8VSP9
EMBL AL391753
AF348706
AY206429
AY879342
AF386526
DQ362850
DQ362864
DQ362865
DQ362866
DQ362867
DQ362868
DQ362869
DQ362870
RefSeq NP_858143.1
WP_001121867.1
WP_010921598.1
YP_006960239.1
YP_009078261.1
PDB 3I0U
PDBsum 3I0U
ProteinModelPortal Q8VSP9
SMR Q8VSP9
IntAct Q8VSP9
STRING 198214.CP0010
PRIDE Q8VSP9
EnsemblBacteria AAL72315
GeneID 1238011
13917039
KEGG sfl:CP0010
eggNOG NOG26011
HOGENOM HOG000028458
KO K13450
OMA FTLYVKP
OrthoDB EOG6MM1JV
EvolutionaryTrace Q8VSP9
Proteomes UP000001006
GO GO:0005576
GO:0016829
GO:0000188
GO:0009405
InterPro IPR003519
Pfam PF03536
PRINTS PR01342

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0075132

negative regulation by symbiont of host protein kinase-mediated signal transduction

PMID:22820255[1]

ECO:0000315

P

Figure 1 indicates the ability of OspF to be specifically targeted to different scaffold complexes (such as yeast osmolarity scaffold Pbs2) where it can inhibit MAPK activity and prevent growth.

complete
CACAO 5947

involved_in

GO:0009405

pathogenesis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0843

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

enables

GO:0016829

lyase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0456

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Wei, P et al. (2012) Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells. Nature 488 384-8 PubMed GONUTS page