SHIFL:IPAD

Species (Taxon ID)	Shigella flexneri. (623)
Gene Name(s)	ipaD
Protein Name(s)	Invasin IpaD 36 kDa membrane antigen
External Links
UniProt	P18013
EMBL	J04117 X15319 AL391753 AF348706 AY206439 AF386526 M34849
PIR	D31265
RefSeq	NP_085288.1 NP_858259.1 YP_009062483.1
PDB	2J0N 2J0O 2JAA 3R9V 4D3E 5VXJ 5VXK 5VXL 5VXM
PDBsum	2J0N 2J0O 2JAA 3R9V 4D3E 5VXJ 5VXK 5VXL 5VXM
ProteinModelPortal	P18013
SMR	P18013
TCDB	1.C.36.3.1
PaxDb	P18013
PRIDE	P18013
EnsemblBacteria	AAL72350
GeneID	1238053 876444
KEGG	sfl:CP0126
PATRIC	fig|198214.7.peg.5381
eggNOG	ENOG4105IBT ENOG4111P3X
HOGENOM	HOG000012181
KO	K13287
EvolutionaryTrace	P18013
Proteomes	UP000001006
GO	GO:0005576 GO:0009405
InterPro	IPR036708 IPR009483
Pfam	PF06511
SUPFAM	SSF140693
TIGRFAMs	TIGR02553

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0034055	positive regulation by symbiont of host defense-related programmed cell death	PMID:27068089	ECO:0000314			P		Organism: Shigella Flexneri The protein is called IpaD. Figure 4A shows that macrophages(part of the host immune system) exposed to the S. flexneri ipaD protein died. Figure 5B shows that ipaD promotes caspace activity, which is part of the apoptotic pathway in cells and part of the defense mechanism of the host, meaning that ipaD upregulated programmed cell death mechanisms in its host.	complete CACAO 12996
involved_in	GO:0009405	pathogenesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009483	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0009405	pathogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0843	P		Seeded From UniProt	complete
edit table

References

See Help:References for how to manage references in GONUTS.