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SHIFL:IPA9
Contents
| Species (Taxon ID) | Shigella flexneri. (623) | |
| Gene Name(s) | ipaH9.8 | |
| Protein Name(s) | E3 ubiquitin-protein ligase ipaH9.8
Invasion plasmid antigen ipaH9.8 RING-type E3 ubiquitin transferase ipaH9.8 (ECO:0000305) | |
| External Links | ||
| UniProt | Q8VSC3 | |
| EMBL | AF047365 AL391753 AF348706 AY206445 AY879342 AF386526 | |
| RefSeq | NP_858359.2 WP_010921715.1 YP_006960318.1 | |
| PDB | 3L3P 5B0N 5B0T | |
| PDBsum | 3L3P 5B0N 5B0T | |
| ProteinModelPortal | Q8VSC3 | |
| SMR | Q8VSC3 | |
| DIP | DIP-46341N | |
| IntAct | Q8VSC3 | |
| MINT | MINT-7993760 | |
| PaxDb | Q8VSC3 | |
| PRIDE | Q8VSC3 | |
| EnsemblBacteria | AAL72345 | |
| GeneID | 1238048 13917118 | |
| KEGG | sfl:CP0226 | |
| PATRIC | fig|198214.7.peg.5483 | |
| eggNOG | ENOG4108QHK COG4886 | |
| HOGENOM | HOG000264729 | |
| KO | K13791 | |
| OMA | RNECSIH | |
| PRO | PR:Q8VSC3 | |
| Proteomes | UP000001006 | |
| GO | GO:0005576 GO:0044164 GO:0042025 GO:0042802 GO:0004842 GO:0085032 GO:0009405 GO:0044314 | |
| Gene3D | 3.80.10.10 | |
| InterPro | IPR032675 IPR032674 IPR029487 | |
| Pfam | PF14496 PF12468 | |
| SUPFAM | SSF52058 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0051865 |
protein autoubiquitination |
ECO:0000314 |
P |
Shigella flexneri. The protein is called IPA9 however it is referred to as IPA9.8 in the article. Figure 4A is an immunoblot assay that shows that IPA9 is able to autoubiquitinate. "...these results suggested that IpaH4.5 possess an autoubiquitination activity as well as IpaH9.8." |
complete | |||||
|
involved_in |
GO:0085032 |
modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0044314 |
protein K27-linked ubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044164 |
host cell cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042025 |
host cell nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030430 |
host cell cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042025 |
host cell nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Wang, F et al. (2013) Shigella flexneri T3SS effector IpaH4.5 modulates the host inflammatory response via interaction with NF-κB p65 protein. Cell. Microbiol. 15 474-85 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Ashida, H et al. (2010) A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKgamma to dampen the host NF-kappaB-mediated inflammatory response. Nat. Cell Biol. 12 66-73; sup pp 1-9 PubMed GONUTS page
- ↑ 3.0 3.1 Rohde, JR et al. (2007) Type III secretion effectors of the IpaH family are E3 ubiquitin ligases. Cell Host Microbe 1 77-83 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Toyotome, T et al. (2001) Shigella protein IpaH(9.8) is secreted from bacteria within mammalian cells and transported to the nucleus. J. Biol. Chem. 276 32071-9 PubMed GONUTS page
- ↑ Seyedarabi, A et al. (2010) A disulfide driven domain swap switches off the activity of Shigella IpaH9.8 E3 ligase. FEBS Lett. 584 4163-8 PubMed GONUTS page
