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SHIFL:IPA7
Contents
| Species (Taxon ID) | Shigella flexneri. (623) | |
| Gene Name(s) | ipaH7.8 | |
| Protein Name(s) | Probable E3 ubiquitin-protein ligase ipaH7.8
Probable RING-type E3 ubiquitin transferase ipaH7.8 (ECO:0000305) | |
| External Links | ||
| UniProt | P18014 | |
| EMBL | AF386526 AF348706 AY879342 AL391753 M32063 | |
| PIR | A35149 | |
| RefSeq | NP_085238.1 NP_858211.1 WP_010921637.1 YP_006960361.1 YP_009062469.1 | |
| PDB | 3CKD | |
| PDBsum | 3CKD | |
| ProteinModelPortal | P18014 | |
| SMR | P18014 | |
| PaxDb | P18014 | |
| PRIDE | P18014 | |
| EnsemblBacteria | AAL72346 | |
| GeneID | 1238049 13917161 876715 | |
| KEGG | sfl:CP0078 | |
| PATRIC | fig|198214.7.peg.5325 | |
| eggNOG | ENOG4108QHK COG4886 | |
| HOGENOM | HOG000290475 | |
| OMA | NEYYLRI | |
| PRO | PR:P18014 | |
| Proteomes | UP000001006 | |
| GO | GO:0005576 GO:0030430 GO:0004842 GO:0009405 | |
| Gene3D | 3.80.10.10 | |
| InterPro | IPR032675 IPR001611 IPR032674 IPR029487 | |
| Pfam | PF14496 PF12468 | |
| SUPFAM | SSF52058 | |
| PROSITE | PS51450 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0034055 |
positive regulation by symbiont of host defense-related programmed cell death |
ECO:0000315 |
P |
Organism: Shigella Flexneri protein: IPAH7.8 (in paper name) IPA7-Uniprot FIg 2A: "Shigella-induced IpaH7.8-dependent cell death occurs via caspase-1 activation...and [showed] that cell death occurred in an IpaH7.8-dependent manner" |
complete | |||||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030430 |
host cell cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Suzuki, S et al. (2014) Shigella IpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages. Proc. Natl. Acad. Sci. U.S.A. 111 E4254-63 PubMed GONUTS page
- ↑ Toyotome, T et al. (2001) Shigella protein IpaH(9.8) is secreted from bacteria within mammalian cells and transported to the nucleus. J. Biol. Chem. 276 32071-9 PubMed GONUTS page
