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SERMA:NUCA

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Species (Taxon ID) Serratia marcescens. (615)
Gene Name(s) nucA (synonyms: nuc)
Protein Name(s) Nuclease

Endonuclease Nuclease isoform Sm2 Nuclease isoform Sm3 Nuclease isoform Sm1

External Links
UniProt P13717
EMBL M19495
PDB 1G8T
1QAE
1QL0
1SMN
4E3Y
PDBsum 1G8T
1QAE
1QL0
1SMN
4E3Y
ProteinModelPortal P13717
SMR P13717
PRIDE P13717
EvolutionaryTrace P13717
GO GO:0005576
GO:0004519
GO:0046872
GO:0003676
Gene3D 3.40.570.10
InterPro IPR018524
IPR001604
IPR020821
Pfam PF01223
SMART SM00892
SM00477
PROSITE PS01070

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

Contributes to

GO:0004518

nuclease activity

PMID:25405367[1]

ECO:0000314

F

Catalyzes hydrolysis of ester linkage with nucleic acid

complete
CACAO 10571

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004519

P

Seeded From UniProt

complete

GO:0003676

nucleic acid binding

PMID:8078761[2]

ECO:0000269

F

Figure 3

complete
CACAO 3388

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004518

P

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001604
InterPro:IPR018524
InterPro:IPR020821

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001604
InterPro:IPR018524
InterPro:IPR020821

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001604
InterPro:IPR018524
InterPro:IPR020821

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0004519

endonuclease activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0255

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

enables

GO:0004518

nuclease activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0540

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Jariwala, N et al. (2015) Role of the staphylococcal nuclease and tudor domain containing 1 in oncogenesis (review). Int. J. Oncol. 46 465-73 PubMed GONUTS page
  2. Friedhoff, P et al. (1994) Identification of catalytically relevant amino acids of the extracellular Serratia marcescens endonuclease by alignment-guided mutagenesis. Nucleic Acids Res. 22 3280-7 PubMed GONUTS page