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SENDZ:V
Contents
Species (Taxon ID) | Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ)). (11198) | |
Gene Name(s) | P/V/C | |
Protein Name(s) | Protein V | |
External Links | ||
UniProt | P69282 | |
EMBL | X00087 | |
ProteinModelPortal | P69282 | |
Proteomes | UP000006560 | |
GO | GO:0005829 GO:0030430 GO:0046872 GO:0039503 GO:0039548 GO:0039554 | |
InterPro | IPR024279 | |
Pfam | PF13008 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0039503 |
suppression by virus of host innate immune response |
ECO:0000315 |
P |
Table 1 reveals the decreased prevelance of virus in mice infected with virus lacking the V protein gene. Background information supports the connection of V protein to suppression of immune response. |
complete | |||||
GO:0044164 |
host cell cytosol |
ECO:0000314 |
C |
Fig.4 |
complete | |||||
GO:0039548 |
suppression by virus of host IRF3 activity |
ECO:0000314 |
P |
Fig 6, 7 & 9. |
complete | |||||
GO:1900226 |
negative regulation of NLRP3 inflammasome complex assembly |
ECO:0000315 |
P |
Figure 2 shows the inhibition of NLRP3 expression levels in cells infected with Sev V protein/Protein V from Sendai virus is present. |
complete | |||||
part_of |
GO:0044164 |
host cell cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0039548 |
suppression by virus of host IRF3 activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0039503 |
suppression by virus of host innate immune response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0046872 |
metal ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0039554 |
suppression by virus of host MDA-5 activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030683 |
evasion or tolerance by virus of host immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0039503 |
suppression by virus of host innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0039548 |
suppression by virus of host IRF3 activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0030430 |
host cell cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Irie, T et al. (2012) Inhibition of interferon regulatory factor 3 activation by paramyxovirus V protein. J. Virol. 86 7136-45 PubMed GONUTS page
- ↑ Komatsu, T et al. (2018) Sendai Virus V Protein Inhibits the Secretion of Interleukin-1β by Preventing NLRP3 Inflammasome Assembly. J. Virol. 92 PubMed GONUTS page
m
s
- Sendai virus
- ssRNA negative-strand viruses
- GO:0039548 ! symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
- GO:0039554 ! symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity