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SENDZ:V

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Species (Taxon ID) Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ)). (11198)
Gene Name(s) P/V/C
Protein Name(s) Protein V
External Links
UniProt P69282
EMBL X00087
ProteinModelPortal P69282
Proteomes UP000006560
GO GO:0005829
GO:0030430
GO:0046872
GO:0039503
GO:0039548
GO:0039554
InterPro IPR024279
Pfam PF13008

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0039503

suppression by virus of host innate immune response

PMID:22532687[1]

ECO:0000315

P

Table 1 reveals the decreased prevelance of virus in mice infected with virus lacking the V protein gene. Background information supports the connection of V protein to suppression of immune response.

complete
CACAO 6740

GO:0044164

host cell cytosol

PMID:22532687[1]

ECO:0000314

C

Fig.4

complete
CACAO 7186

GO:0039548

suppression by virus of host IRF3 activity

PMID:22532687[1]

ECO:0000314

P

Fig 6, 7 & 9.

complete
CACAO 7295

GO:1900226

negative regulation of NLRP3 inflammasome complex assembly

PMID:30021903[2]

ECO:0000315

P

Figure 2 shows the inhibition of NLRP3 expression levels in cells infected with Sev V protein/Protein V from Sendai virus is present.

complete
CACAO 13434

part_of

GO:0044164

host cell cytosol

PMID:22532687[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0039548

suppression by virus of host IRF3 activity

PMID:22532687[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0039503

suppression by virus of host innate immune response

PMID:22532687[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024279

F

Seeded From UniProt

complete

involved_in

GO:0039554

suppression by virus of host MDA-5 activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1089

P

Seeded From UniProt

complete

involved_in

GO:0030683

evasion or tolerance by virus of host immune response

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0922
UniProtKB-KW:KW-0899

P

Seeded From UniProt

complete

involved_in

GO:0039503

suppression by virus of host innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1090

P

Seeded From UniProt

complete

involved_in

GO:0039548

suppression by virus of host IRF3 activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1092

P

Seeded From UniProt

complete

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

part_of

GO:0030430

host cell cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1035
UniProtKB-SubCell:SL-0381

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Irie, T et al. (2012) Inhibition of interferon regulatory factor 3 activation by paramyxovirus V protein. J. Virol. 86 7136-45 PubMed GONUTS page
  2. Komatsu, T et al. (2018) Sendai Virus V Protein Inhibits the Secretion of Interleukin-1β by Preventing NLRP3 Inflammasome Assembly. J. Virol. 92 PubMed GONUTS page