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SALTY:SSEL
Contents
| Species (Taxon ID) | Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720). (99287) | |
| Gene Name(s) | sseL | |
| Protein Name(s) | Deubiquitinase SseL
Deubiquitinating enzyme DUB Deubiquitinating protease Salmonella secreted effector L | |
| External Links | ||
| UniProt | Q8ZNG2 | |
| EMBL | AE006468 | |
| RefSeq | NP_461229.2 | |
| ProteinModelPortal | Q8ZNG2 | |
| DIP | DIP-60877N | |
| STRING | 99287.STM2287 | |
| PaxDb | Q8ZNG2 | |
| PRIDE | Q8ZNG2 | |
| EnsemblBacteria | AAL21188 | |
| GeneID | 1253809 | |
| KEGG | stm:STM2287 | |
| PATRIC | 32383183 | |
| eggNOG | NOG13740 | |
| HOGENOM | HOG000071515 | |
| KO | K18015 | |
| OMA | YRLSTPQ | |
| BioCyc | SENT99287:GCTI-2302-MONOMER | |
| Proteomes | UP000001014 | |
| GO | GO:0030430 GO:0008234 GO:0009405 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0019783 |
ECO:0000250 |
UniProtKB:P31498 UniProtKB:Q08926 UniProtKB:Q9P0U3
|
SseL has the same catalytic amino acids as the clan of Cysteine Proteases as per Figure 1 |
complete | ||||||
| GO:0009405 |
pathogenesis |
ECO:0000315 |
P |
SseL is required for a delayed cytotoxic effect in infected macrophages. (Figure 4) |
complete | |||||
| GO:0004843 |
ubiquitin-specific protease activity |
ECO:0000314 |
F |
Figure 7 |
complete | |||||
|
part_of |
GO:0030430 |
host cell cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008234 |
cysteine-type peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Rytkönen, A et al. (2007) SseL, a Salmonella deubiquitinase required for macrophage killing and virulence. Proc. Natl. Acad. Sci. U.S.A. 104 3502-7 PubMed GONUTS page
- ↑ Beuzón, CR et al. (1999) pH-dependent secretion of SseB, a product of the SPI-2 type III secretion system of Salmonella typhimurium. Mol. Microbiol. 33 806-16 PubMed GONUTS page
- ↑ Arena, ET et al. (2011) The deubiquitinase activity of the Salmonella pathogenicity island 2 effector, SseL, prevents accumulation of cellular lipid droplets. Infect. Immun. 79 4392-400 PubMed GONUTS page
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