SALTY:NPD

Species (Taxon ID)	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720). (99287)
Gene Name(s)	cobB (ECO:0000255 with HAMAP-Rule:MF_01121)
Protein Name(s)	NAD-dependent protein deacylase (ECO:0000255 with HAMAP-Rule:MF_01121) Regulatory protein SIR2 homolog (ECO:0000255 with HAMAP-Rule:MF_01121)
External Links
UniProt	P0A2F2
EMBL	U89687 AE006468
RefSeq	NP_460191.1
STRING	99287.STM1221
PaxDb	P0A2F2
PRIDE	P0A2F2
EnsemblBacteria	AAL20150
GeneID	1252739
KEGG	stm:STM1221
PATRIC	32380891
eggNOG	COG0846
HOGENOM	HOG000085950
KO	K12410
OrthoDB	EOG6VQPX1
BioCyc	SENT99287:GCTI-1230-MONOMER
Proteomes	UP000001014
GO	GO:0005737 GO:0070403 GO:0034979 GO:0036054 GO:0036055 GO:0008270
Gene3D	3.30.1600.10 3.40.50.1220
HAMAP	MF_01121
InterPro	IPR029035 IPR003000 IPR026591 IPR027546 IPR026590
PANTHER	PTHR11085
Pfam	PF02146
SUPFAM	SSF52467
PROSITE	PS50305

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0051591	response to cAMP	PMID:27974467	ECO:0000314			P		Organism: Salmonella enterica (Salmonella typhimurium). Paper's Protein Name: NAD+-dependent deacetylase (CobB). UniProt's Protein Name: NAD-dependent protein deacylase. "The result in Fig. 2D confirmed that SeCobB was able to remove the acetyl group on Lys609 of SeAcs (lane 4), and rescued SeAcs activity. However, decrease in the acetylation level as well as the recovery of SeAcs activity by CobB treatment was inhibited remarkably in the presence of cAMP (lane 7)."	complete CACAO 12276
involved_in	GO:0036047	peptidyl-lysine demalonylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0036054	P		Seeded From UniProt	complete
involved_in	GO:0036049	peptidyl-lysine desuccinylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0036055	P		Seeded From UniProt	complete
involved_in	GO:0036049	peptidyl-lysine desuccinylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0036055	P		Seeded From UniProt	complete
enables	GO:0036054	protein-malonyllysine demalonylase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027546	F		Seeded From UniProt	complete
enables	GO:0036055	protein-succinyllysine desuccinylase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027546	F		Seeded From UniProt	complete
enables	GO:0070403	NAD+ binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003000 InterPro:IPR027546	F		Seeded From UniProt	complete
involved_in	GO:0036048	protein desuccinylation	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000334654	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000334654	F		Seeded From UniProt	complete
involved_in	GO:0006476	protein deacetylation	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000334654	P		Seeded From UniProt	complete
enables	GO:0036055	protein-succinyllysine desuccinylase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000334654	F		Seeded From UniProt	complete
enables	GO:0070403	NAD+ binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000334654	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000334654	C		Seeded From UniProt	complete
enables	GO:0034979	NAD-dependent protein deacetylase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000334654	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
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References

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