SALTY:COBT

Species (Taxon ID)	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720). (99287)
Gene Name(s)	cobT
Protein Name(s)	Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase NN:DBI PRT N(1)-alpha-phosphoribosyltransferase
External Links
UniProt	Q05603
EMBL	L35477 AE006468 L12006
RefSeq	NP_460961.1
PDB	1D0S 1D0V 1JH8 1JHA 1JHM 1JHO 1JHP 1JHQ 1JHR 1JHU 1JHV 1JHX 1JHY 1L4B 1L4E 1L4F 1L4G 1L4H 1L4K 1L4L 1L4M 1L4N 1L5F 1L5K 1L5L 1L5M 1L5N 1L5O 4KQF 4KQG 4KQH 4KQI 4KQJ 4KQK
PDBsum	1D0S 1D0V 1JH8 1JHA 1JHM 1JHO 1JHP 1JHQ 1JHR 1JHU 1JHV 1JHX 1JHY 1L4B 1L4E 1L4F 1L4G 1L4H 1L4K 1L4L 1L4M 1L4N 1L5F 1L5K 1L5L 1L5M 1L5N 1L5O 4KQF 4KQG 4KQH 4KQI 4KQJ 4KQK
ProteinModelPortal	Q05603
SMR	Q05603
STRING	99287.STM2016
DrugBank	DB00173 DB03255
PaxDb	Q05603
PRIDE	Q05603
EnsemblBacteria	AAL20920
GeneID	1253537
KEGG	stm:STM2016
PATRIC	32382615
eggNOG	COG2038
HOGENOM	HOG000263499
KO	K00768
OMA	MNNMATF
OrthoDB	EOG6HF61K
PhylomeDB	Q05603
BioCyc	MetaCyc:MONOMER-13214 SENT99287:GCTI-2028-MONOMER
UniPathway	UPA00061
EvolutionaryTrace	Q05603
Proteomes	UP000001014
GO	GO:0015420 GO:0008939 GO:0009236 GO:0009163
Gene3D	1.10.1610.10
HAMAP	MF_00230
InterPro	IPR003200 IPR023195 IPR017846
Pfam	PF02277
SUPFAM	SSF52733
TIGRFAMs	TIGR03160

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0008939	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity	PMID:8206834	ECO:0000314			F		Figure 2 shows a TLC plate's separation of the reactants and products of the S. typhimurium CobT protein reaction with 2 different cell extracts: one with chromosomally (normal) encoded levels of CobT, and another with overexpressed levels of CobT. The separation indicates that the CobT-overexpressing cells have much greater alpha-ribazole-5'-P and the normal cells have much greater DMB (5,6-dimethylbenzimidazole). The separation indicates that CobT activity catalyzes the reaction from DMB to alpha-ribazole-5'-P, thus demonstrating nicotinate-nucleotide-dimethylbenzimadazole phosphoribosyltransferase activity.	complete CACAO 4863
enables	GO:0008939	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity	PMID:8206834	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0015889	cobalamin transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0015420	P		Seeded From UniProt	complete
enables	GO:0008939	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003200 InterPro:IPR017846 InterPro:IPR023195 InterPro:IPR036087	F		Seeded From UniProt	complete
involved_in	GO:0009163	nucleoside biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017846	P		Seeded From UniProt	complete
involved_in	GO:0009236	cobalamin biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003200 InterPro:IPR023195 InterPro:IPR036087	P		Seeded From UniProt	complete
enables	GO:0008939	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.4.2.21	F		Seeded From UniProt	complete
enables	GO:0008939	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000081111	F		Seeded From UniProt	complete
enables	GO:0015420	cobalamin-transporting ATPase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000081111	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016757	transferase activity, transferring glycosyl groups	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0328	F		Seeded From UniProt	complete
involved_in	GO:0009236	cobalamin biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0169	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
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References

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