RSVP:POL

Species (Taxon ID)	Rous sarcoma virus (strain Prague C) (RSV-PrC). (11888)
Gene Name(s)	gag-pol
Protein Name(s)	Gag-Pol polyprotein Matrix protein p19 p2A p2B p10 Capsid protein p27, alternate cleaved 1 Capsid protein p27, alternate cleaved 2 Spacer peptide SP p3 Nucleocapsid protein p12 Protease p15 Reverse transcriptase, beta-subunit RT-beta Reverse transcriptase, alpha-subunit RT-alpha Integrase IN pp32 p4
External Links
UniProt	P03354
EMBL	V01197 J02342 X68524 AF033808
PIR	A03955
RefSeq	NP_056886.1
PDB	1BAI 1C0M 1C1A 3TIR 4FW1 4FW2 5EJK 5KZ9 5KZA 5KZB 6CCJ 6CE5 6CUS 6CV8 6CW4
PDBsum	1BAI 1C0M 1C1A 3TIR 4FW1 4FW2 5EJK 5KZ9 5KZA 5KZB 6CCJ 6CE5 6CUS 6CV8 6CW4
SMR	P03354
BindingDB	P03354
ChEMBL	CHEMBL2750
PRIDE	P03354
GeneID	2193432
KEGG	vg:2193432
EvolutionaryTrace	P03354
Proteomes	UP000007183 UP000137552
GO	GO:0019013 GO:0004190 GO:0003677 GO:0003887 GO:0003723 GO:0003964 GO:0004523 GO:0008270 GO:0015074 GO:0006310 GO:0075713 GO:0001171 GO:0046718 GO:0044826
CDD	cd05482
Gene3D	1.10.10.200 1.10.1200.30 1.10.150.90 1.10.375.10 2.30.30.10 2.40.70.10 3.30.420.10
InterPro	IPR001969 IPR004028 IPR000721 IPR017856 IPR036862 IPR001037 IPR001584 IPR003308 IPR012344 IPR001995 IPR021109 IPR034170 IPR018061 IPR008916 IPR008919 IPR010999 IPR012337 IPR002156 IPR036397 IPR000477 IPR010661 IPR001878 IPR036875
Pfam	PF00607 PF00552 PF02022 PF02813 PF00665 PF00077 PF00078 PF06817 PF00098
SMART	SM00343
SUPFAM	SSF46919 SSF47836 SSF47943 SSF50122 SSF50630 SSF53098 SSF57756
PROSITE	PS50175 PS00141 PS50994 PS51027 PS50879 PS50878 PS50158 PS50876

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004519	P	Seeded From UniProt
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004518	P	Seeded From UniProt
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004523	P	Seeded From UniProt
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004523	P	Seeded From UniProt
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001037 InterPro:IPR001878 InterPro:IPR002156 InterPro:IPR036397 InterPro:IPR036862 InterPro:IPR036875	F	Seeded From UniProt
enables	GO:0003964	RNA-directed DNA polymerase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010661	F	Seeded From UniProt
enables	GO:0004190	aspartic-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001969 InterPro:IPR001995	F	Seeded From UniProt
enables	GO:0004523	RNA-DNA hybrid ribonuclease activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002156	F	Seeded From UniProt
involved_in	GO:0006278	RNA-dependent DNA biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010661	P	Seeded From UniProt
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001969 InterPro:IPR001995	P	Seeded From UniProt
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001878 InterPro:IPR003308 InterPro:IPR036875	F	Seeded From UniProt
involved_in	GO:0015074	DNA integration	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001584	P	Seeded From UniProt
involved_in	GO:0016032	viral process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000721 InterPro:IPR008919	P	Seeded From UniProt
enables	GO:0004523	RNA-DNA hybrid ribonuclease activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.26.4	F	Seeded From UniProt
enables	GO:0003887	DNA-directed DNA polymerase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.7.7	F	Seeded From UniProt
enables	GO:0003964	RNA-directed DNA polymerase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.7.49	F	Seeded From UniProt
involved_in	GO:0001171	reverse transcription	PMID:10708441^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt
enables	GO:0003887	DNA-directed DNA polymerase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0239	F	Seeded From UniProt
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P	Seeded From UniProt
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F	Seeded From UniProt
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	F	Seeded From UniProt
part_of	GO:0019013	viral nucleocapsid	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0543	C	Seeded From UniProt
involved_in	GO:0006310	DNA recombination	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0233	P	Seeded From UniProt
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt
enables	GO:0016779	nucleotidyltransferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0548	F	Seeded From UniProt
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt
part_of	GO:0019028	viral capsid	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0167	C	Seeded From UniProt
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F	Seeded From UniProt
enables	GO:0003964	RNA-directed DNA polymerase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0695	F	Seeded From UniProt
involved_in	GO:0075713	establishment of integrated proviral latency	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1179	P	Seeded From UniProt
involved_in	GO:0044826	viral genome integration into host DNA	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1179	P	Seeded From UniProt
part_of	GO:0019012	virion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0946 UniProtKB-SubCell:SL-0274	C	Seeded From UniProt
involved_in	GO:0015074	DNA integration	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0229	P	Seeded From UniProt
enables	GO:0004518	nuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0540	F	Seeded From UniProt
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt
involved_in	GO:0046718	viral entry into host cell	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1160	P	Seeded From UniProt
enables	GO:0004190	aspartic-type endopeptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0064	F	Seeded From UniProt
enables	GO:0004519	endonuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0255	F	Seeded From UniProt
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	P	Seeded From UniProt
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004519	P	Seeded From UniProt
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004518	P	Seeded From UniProt
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004523	P	Seeded From UniProt
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004523	P	Seeded From UniProt
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001037 InterPro:IPR001878 InterPro:IPR002156 InterPro:IPR036397 InterPro:IPR036862 InterPro:IPR036875	F	Seeded From UniProt
enables	GO:0003964	RNA-directed DNA polymerase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010661	F	Seeded From UniProt
enables	GO:0004190	aspartic-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001969 InterPro:IPR001995	F	Seeded From UniProt
enables	GO:0004523	RNA-DNA hybrid ribonuclease activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002156	F	Seeded From UniProt
involved_in	GO:0006278	RNA-dependent DNA biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010661	P	Seeded From UniProt
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001969 InterPro:IPR001995	P	Seeded From UniProt
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001878 InterPro:IPR003308 InterPro:IPR036875	F	Seeded From UniProt
involved_in	GO:0015074	DNA integration	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001584	P	Seeded From UniProt
involved_in	GO:0016032	viral process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000721 InterPro:IPR008919	P	Seeded From UniProt
enables	GO:0004523	RNA-DNA hybrid ribonuclease activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.26.4	F	Seeded From UniProt
enables	GO:0003887	DNA-directed DNA polymerase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.7.7	F	Seeded From UniProt
enables	GO:0003964	RNA-directed DNA polymerase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.7.49	F	Seeded From UniProt
enables	GO:0003887	DNA-directed DNA polymerase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0239	F	Seeded From UniProt
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P	Seeded From UniProt
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F	Seeded From UniProt
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	F	Seeded From UniProt
part_of	GO:0019013	viral nucleocapsid	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0543	C	Seeded From UniProt
involved_in	GO:0006310	DNA recombination	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0233	P	Seeded From UniProt
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt
enables	GO:0016779	nucleotidyltransferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0548	F	Seeded From UniProt
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt
part_of	GO:0019028	viral capsid	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0167	C	Seeded From UniProt
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F	Seeded From UniProt
enables	GO:0003964	RNA-directed DNA polymerase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0695	F	Seeded From UniProt
involved_in	GO:0075713	establishment of integrated proviral latency	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1179	P	Seeded From UniProt
involved_in	GO:0044826	viral genome integration into host DNA	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1179	P	Seeded From UniProt
part_of	GO:0019012	virion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0946 UniProtKB-SubCell:SL-0274	C	Seeded From UniProt
involved_in	GO:0015074	DNA integration	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0229	P	Seeded From UniProt
enables	GO:0004518	nuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0540	F	Seeded From UniProt
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt
involved_in	GO:0046718	viral entry into host cell	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1160	P	Seeded From UniProt
enables	GO:0004190	aspartic-type endopeptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0064	F	Seeded From UniProt
enables	GO:0004519	endonuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0255	F	Seeded From UniProt
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	P	Seeded From UniProt
part_of	GO:0019012	virion	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0274	C	Seeded From UniProt
involved_in	GO:0001171	reverse transcription	PMID:10708441^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt
	GO:0003964	RNA-directed DNA polymerase activity	PMID:4316300^[2]	ECO:0005801	enzymatic activity assay evidence used in manual assertion		F	Figure 1 and Tables 2/3 demonstrate an RSV DNA polymerase (RSV Prague C Pol) activity dependent on RNA template	complete
	GO:0001171	reverse transcription	PMID:4316300^[2]	ECO:0005801			P	Table 5 shows that the RSV (Rous Sarcoma Virus) virion has DNA Pol activity	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Werner, S & Wöhrl, BM (2000) Asymmetric subunit organization of heterodimeric Rous sarcoma virus reverse transcriptase alphabeta: localization of the polymerase and RNase H active sites in the alpha subunit. J. Virol. 74 3245-52 PubMed GONUTS page
↑ ^2.0 ^2.1 Baltimore, D (1970) RNA-dependent DNA polymerase in virions of RNA tumour viruses. Nature 226 1209-11 PubMed GONUTS page

[PMID:10708441-1] 1.0 ^1.1 Werner, S & Wöhrl, BM (2000) Asymmetric subunit organization of heterodimeric Rous sarcoma virus reverse transcriptase alphabeta: localization of the polymerase and RNase H active sites in the alpha subunit. J. Virol. 74 3245-52 PubMed GONUTS page

[PMID:4316300-2] 2.0 ^2.1 Baltimore, D (1970) RNA-dependent DNA polymerase in virions of RNA tumour viruses. Nature 226 1209-11 PubMed GONUTS page

[1]

[2]

RSVP:POL

Contents

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