RAT:TNNI3

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Tnni3 (synonyms: Ctni, Tni)
Protein Name(s)	Troponin I, cardiac muscle Cardiac troponin I
External Links
UniProt	P23693
EMBL	M57679 X58499 M92074 U77354 DQ062462
PIR	A60124 I56441
RefSeq	NP_058840.1
UniGene	Rn.64141
ProteinModelPortal	P23693
SMR	P23693
BioGrid	247923
STRING	10116.ENSRNOP00000024640
PhosphoSite	P23693
PaxDb	P23693
PRIDE	P23693
Ensembl	ENSRNOT00000024640
GeneID	29248
KEGG	rno:29248
UCSC	RGD:62052
CTD	7137
RGD	62052
eggNOG	NOG270363
GeneTree	ENSGT00390000002746
HOGENOM	HOG000293300
HOVERGEN	HBG052737
InParanoid	P23693
KO	K12044
OMA	TKHKVSM
OrthoDB	EOG71G9WD
PhylomeDB	P23693
TreeFam	TF313374
Reactome	REACT_234304
NextBio	608538
PRO	PR:P23693
Proteomes	UP000002494
Genevestigator	P23693
GO	GO:0043292 GO:0005737 GO:0030016 GO:0030017 GO:0005861 GO:0019855 GO:0046872 GO:0060048 GO:0006874 GO:0032780 GO:0006937 GO:0006940 GO:0001980 GO:0001570 GO:0055010
InterPro	IPR001978 IPR021666
Pfam	PF00992 PF11636

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0060048	cardiac muscle contraction	PMID:9409484^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060048	cardiac muscle contraction	PMID:14551059^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060048	cardiac muscle contraction	PMID:11448842^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043292	contractile fiber	PMID:9409484^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030016	myofibril	PMID:11448842^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006940	regulation of smooth muscle contraction	PMID:16236710^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060048	cardiac muscle contraction	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001011175 RGD:62052 UniProtKB:P19429	P	Seeded From UniProt	complete
involved_in	GO:0006936	muscle contraction	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000348305 WB:WBGene00006585	P	Seeded From UniProt	complete
part_of	GO:0005861	troponin complex	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000348305 RGD:62050 RGD:621765 UniProtKB:P19429 UniProtKB:P48788	C	Seeded From UniProt	complete
involved_in	GO:0003009	skeletal muscle contraction	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001011175 UniProtKB:P48788	P	Seeded From UniProt	complete
part_of	GO:0030017	sarcomere	PMID:15601779^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15601779^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:1990584	cardiac Troponin complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19429 ensembl:ENSP00000341838	C	Seeded From UniProt	complete
part_of	GO:0097512	cardiac myofibril	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19429 ensembl:ENSP00000341838	C	Seeded From UniProt	complete
involved_in	GO:0060048	cardiac muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19429 ensembl:ENSP00000341838	P	Seeded From UniProt	complete
involved_in	GO:0060047	heart contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19429 ensembl:ENSP00000341838	P	Seeded From UniProt	complete
involved_in	GO:0055010	ventricular cardiac muscle tissue morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19429 ensembl:ENSP00000341838	P	Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19429 ensembl:ENSP00000341838	F	Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19429 ensembl:ENSP00000341838	F	Seeded From UniProt	complete
involved_in	GO:0032780	negative regulation of ATPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19429 ensembl:ENSP00000341838	P	Seeded From UniProt	complete
enables	GO:0031014	troponin T binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19429 ensembl:ENSP00000341838	F	Seeded From UniProt	complete
enables	GO:0030172	troponin C binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19429 ensembl:ENSP00000341838	F	Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19429 ensembl:ENSP00000341838	F	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19429 ensembl:ENSP00000341838	F	Seeded From UniProt	complete
enables	GO:0019855	calcium channel inhibitor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19429 ensembl:ENSP00000341838	F	Seeded From UniProt	complete
involved_in	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19429 ensembl:ENSP00000341838	P	Seeded From UniProt	complete
part_of	GO:0005861	troponin complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19429 ensembl:ENSP00000341838	C	Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19429 ensembl:ENSP00000341838	F	Seeded From UniProt	complete
part_of	GO:0030017	sarcomere	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48787 ensembl:ENSMUSP00000096458	C	Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48787 ensembl:ENSMUSP00000096458	P	Seeded From UniProt	complete
involved_in	GO:0006941	striated muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48787 ensembl:ENSMUSP00000096458	P	Seeded From UniProt	complete
involved_in	GO:0006937	regulation of muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48787 ensembl:ENSMUSP00000096458	P	Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48787 ensembl:ENSMUSP00000096458	P	Seeded From UniProt	complete
involved_in	GO:0001980	regulation of systemic arterial blood pressure by ischemic conditions	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48787 ensembl:ENSMUSP00000096458	P	Seeded From UniProt	complete
involved_in	GO:0001570	vasculogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48787 ensembl:ENSMUSP00000096458	P	Seeded From UniProt	complete
part_of	GO:0005861	troponin complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001978	C	Seeded From UniProt	complete
involved_in	GO:0006937	regulation of muscle contraction	PMID:9065755^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005861	troponin complex	PMID:1886137^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0009	F	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Rossmanith, GH et al. (1997) Mechanism of action of endothelin in rat cardiac muscle: cross-bridge kinetics and myosin light chain phosphorylation. J. Physiol. (Lond.) 505 ( Pt 1) 217-27 PubMed GONUTS page
↑ Radisic, M et al. (2004) Medium perfusion enables engineering of compact and contractile cardiac tissue. Am. J. Physiol. Heart Circ. Physiol. 286 H507-16 PubMed GONUTS page
↑ ^3.0 ^3.1 Wu, LL et al. (2001) Altered phosphorylation and calcium sensitivity of cardiac myofibrillar proteins during sepsis. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281 R408-16 PubMed GONUTS page
↑ Westfall, MV et al. (2005) Differential contribution of troponin I phosphorylation sites to the endothelin-modulated contractile response. J. Biol. Chem. 280 41324-31 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^6.0 ^6.1 Kedar, V et al. (2004) Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I. Proc. Natl. Acad. Sci. U.S.A. 101 18135-40 PubMed GONUTS page
↑ Murphy, AM et al. (1997) Regulation of the rat cardiac troponin I gene by the transcription factor GATA-4. Biochem. J. 322 ( Pt 2) 393-401 PubMed GONUTS page
↑ Martin, AF & Orlowski, J (1991) Molecular cloning and developmental expression of the rat cardiac-specific isoform of troponin I. J. Mol. Cell. Cardiol. 23 583-8 PubMed GONUTS page

[PMID:9409484-1] 1.0 ^1.1 Rossmanith, GH et al. (1997) Mechanism of action of endothelin in rat cardiac muscle: cross-bridge kinetics and myosin light chain phosphorylation. J. Physiol. (Lond.) 505 ( Pt 1) 217-27 PubMed GONUTS page

[PMID:14551059-2] Radisic, M et al. (2004) Medium perfusion enables engineering of compact and contractile cardiac tissue. Am. J. Physiol. Heart Circ. Physiol. 286 H507-16 PubMed GONUTS page

[PMID:11448842-3] 3.0 ^3.1 Wu, LL et al. (2001) Altered phosphorylation and calcium sensitivity of cardiac myofibrillar proteins during sepsis. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281 R408-16 PubMed GONUTS page

[PMID:16236710-4] Westfall, MV et al. (2005) Differential contribution of troponin I phosphorylation sites to the endothelin-modulated contractile response. J. Biol. Chem. 280 41324-31 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15601779-6] 6.0 ^6.1 Kedar, V et al. (2004) Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I. Proc. Natl. Acad. Sci. U.S.A. 101 18135-40 PubMed GONUTS page

[PMID:9065755-7] Murphy, AM et al. (1997) Regulation of the rat cardiac troponin I gene by the transcription factor GATA-4. Biochem. J. 322 ( Pt 2) 393-401 PubMed GONUTS page

[PMID:1886137-8] Martin, AF & Orlowski, J (1991) Molecular cloning and developmental expression of the rat cardiac-specific isoform of troponin I. J. Mol. Cell. Cardiol. 23 583-8 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

RAT:TNNI3

Contents

Annotations

Notes

References

a

c

e

g

h

i

m

n

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools