RAT:SYT1

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Syt1
Protein Name(s)	Synaptotagmin-1 Synaptotagmin I SytI p65
External Links
UniProt	P21707
EMBL	X52772 AJ617615 DQ181550
PIR	S09595
RefSeq	NP_001028852.2 XP_017450168.1
UniGene	Rn.216272
PDB	1BYN 1K5W 1RSY 1TJM 1TJX 1UOV 1UOW 2YOA 4WEE 5CCG 5CCH 5CCI 5CCJ 5KJ7 5KJ8 5W5C 5W5D
PDBsum	1BYN 1K5W 1RSY 1TJM 1TJX 1UOV 1UOW 2YOA 4WEE 5CCG 5CCH 5CCI 5CCJ 5KJ7 5KJ8 5W5C 5W5D
ProteinModelPortal	P21707
SMR	P21707
BioGrid	247745
CORUM	P21707
DIP	DIP-29064N
IntAct	P21707
MINT	P21707
STRING	10116.ENSRNOP00000049624
iPTMnet	P21707
PhosphoSitePlus	P21707
SwissPalm	P21707
PaxDb	P21707
PRIDE	P21707
Ensembl	ENSRNOT00000048880 ENSRNOT00000088950
GeneID	25716
KEGG	rno:25716
UCSC	RGD:3803
CTD	6857
RGD	3803
eggNOG	ENOG410IT3Q ENOG410Z15P
GeneTree	ENSGT00760000118973
HOGENOM	HOG000232127
HOVERGEN	HBG005010
InParanoid	P21707
KO	K15290
OMA	HDIIGEY
OrthoDB	EOG091G0XMQ
PhylomeDB	P21707
TreeFam	TF315600
Reactome	R-RNO-181429 R-RNO-181430 R-RNO-210500 R-RNO-212676 R-RNO-264642 R-RNO-8856825 R-RNO-8856828 R-RNO-888590
EvolutionaryTrace	P21707
PRO	PR:P21707
Proteomes	UP000002494
Bgee	ENSRNOG00000006426
Genevisible	P21707
GO	GO:0030424 GO:0030054 GO:0042584 GO:0005737 GO:0031045 GO:0060076 GO:0070382 GO:0098978 GO:0005794 GO:0098686 GO:0030285 GO:0043229 GO:0044306 GO:0005886 GO:0042734 GO:0030141 GO:0008021 GO:0030672 GO:0043195 GO:0005509 GO:0005544 GO:0048306 GO:0005516 GO:0030276 GO:0042802 GO:0050750 GO:0005546 GO:0001786 GO:0005543 GO:0008022 GO:0046982 GO:0042803 GO:0000149 GO:0019905 GO:0017075 GO:0030348 GO:0007420 GO:0017156 GO:0048791 GO:0099502 GO:0071277 GO:0005513 GO:0098746 GO:0045956 GO:1903861 GO:0050806 GO:0031340 GO:0051291 GO:0051260 GO:0017158 GO:0014059 GO:1903305 GO:0051966 GO:0051592 GO:0048488 GO:0016079 GO:0048278 GO:0016192
Gene3D	2.60.40.150
InterPro	IPR000008 IPR035892 IPR001565 IPR015428
PANTHER	PTHR10024:SF239
Pfam	PF00168
PRINTS	PR00360 PR00399
SMART	SM00239
PROSITE	PS50004

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0033603	dopamine secretion	PMID:28370453^[1]	ECO:0000315			P		Figure 4c shows that in the absence of RAB3a the dopamine content was significantly lower after the SYT1 knockdown when compared to figure 2c - without the SYT 1 knockdown. The proteins are taken from rats.	complete CACAO 13419
part_of	GO:0030672	synaptic vesicle membrane	PMID:23792689^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	PMID:9830048^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	PMID:9830048^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P21707	P	occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:0051291	protein heterooligomerization	PMID:9830048^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P50232	P	occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
part_of	GO:0044306	neuron projection terminus	PMID:10397765^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0030348	syntaxin-3 binding	PMID:10397765^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q08849	F		Seeded From UniProt	complete
enables	GO:0019905	syntaxin binding	PMID:10397765^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q08850	F		Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	PMID:10397765^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P32851)\|has_direct_input:(UniProtKB:Q08850)\|has_direct_input:(UniProtKB:P50279)\|has_direct_input:(UniProtKB:Q08849)	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:10397765^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P50232	F		Seeded From UniProt	complete
involved_in	GO:0031340	positive regulation of vesicle fusion	PMID:20688915^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000149	SNARE binding	PMID:20688915^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P32851,UniProtKB:P60881	F		Seeded From UniProt	complete
enables	GO:0019905	syntaxin binding	PMID:10397765^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P50279	F		Seeded From UniProt	complete
enables	GO:0017075	syntaxin-1 binding	PMID:10397765^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P32851	F		Seeded From UniProt	complete
enables	GO:0001786	phosphatidylserine binding	PMID:20688915^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	PMID:20688915^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	PMID:12860971^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	activated_by:(CHEBI:29108) part_of:(GO:0017158)	Seeded From UniProt	complete
involved_in	GO:0017158	regulation of calcium ion-dependent exocytosis	PMID:12860971^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000149	SNARE binding	PMID:12860971^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	activated_by:(CHEBI:29108) part_of:(GO:0017158)	Seeded From UniProt	complete
enables	GO:0001786	phosphatidylserine binding	PMID:12860971^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	activated_by:(CHEBI:29108)	Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	PMID:17110340^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	PMID:9830048^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P50232)\|has_direct_input:(UniProtKB:P21707)\|has_direct_input:(UniProtKB:P40748)	Seeded From UniProt	complete
involved_in	GO:0051291	protein heterooligomerization	PMID:9830048^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P40748	P	occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
part_of	GO:0030285	integral component of synaptic vesicle membrane	PMID:17110340^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071277	cellular response to calcium ion	PMID:12526776^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043195	terminal bouton	PMID:24876496^[9]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:0051966	regulation of synaptic transmission, glutamatergic	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P46096	P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0098746	fast, calcium ion-dependent exocytosis of neurotransmitter	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P46096	P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0050806	positive regulation of synaptic transmission	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P46096	P	occurs_in:(CL:1001571)	Seeded From UniProt	complete
involved_in	GO:0098746	fast, calcium ion-dependent exocytosis of neurotransmitter	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P46096	P	occurs_in:(CL:1001571)	Seeded From UniProt	complete
enables	GO:0017075	syntaxin-1 binding	PMID:12526776^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(UBERON:0000955) part_of:(GO:0071277)	Seeded From UniProt	complete
enables	GO:0000149	SNARE binding	PMID:12526776^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P63045	F	occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
enables	GO:0000149	SNARE binding	PMID:12526776^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P60881	F	occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	PMID:8253763^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1903305	regulation of regulated secretory pathway	PMID:12526776^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000165)	Seeded From UniProt	complete
colocalizes_with	GO:0031201	SNARE complex	PMID:23949442^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0060076	excitatory synapse	PMID:19730411^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0030276	clathrin binding	PMID:7791877^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0019905	syntaxin binding	PMID:7791877^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	PMID:18179895^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:18179895^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	PMID:7791877^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0098686	hippocampal mossy fiber to CA3 synapse	PMID:7298720^[15]	ECO:0006003	electron microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098686	hippocampal mossy fiber to CA3 synapse	PMID:7298720^[15]	ECO:0001232	microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030285	integral component of synaptic vesicle membrane	PMID:7298720^[15]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002037)	Seeded From UniProt	complete
part_of	GO:0030285	integral component of synaptic vesicle membrane	PMID:7298720^[15]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098686)	Seeded From UniProt	complete
part_of	GO:0030285	integral component of synaptic vesicle membrane	PMID:7298720^[15]	ECO:0001232	microscopy evidence used in manual assertion		C	part_of:(UBERON:0002037)	Seeded From UniProt	complete
part_of	GO:0030285	integral component of synaptic vesicle membrane	PMID:7298720^[15]	ECO:0001232	microscopy evidence used in manual assertion		C	part_of:(GO:0098686)	Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:19132534^[16]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:70945	F		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	PMID:8872307^[17]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	PMID:22447935^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	PMID:22711810^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	PMID:2333096^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	PMID:2333096^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0005513	detection of calcium ion	PMID:22229667^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0005513	detection of calcium ion	PMID:21551071^[22]	ECO:0000305	curator inference used in manual assertion	GO:0045956	P		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:22711810^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:22447935^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:15340165^[23]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001786	phosphatidylserine binding	PMID:18508778^[24]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000149	SNARE binding	PMID:22711810^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000149	SNARE binding	PMID:19132534^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000149	SNARE binding	PMID:18508778^[24]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051592	response to calcium ion	PMID:18508778^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	PMID:22711810^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0048278	vesicle docking	PMID:22229667^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045956	positive regulation of calcium ion-dependent exocytosis	PMID:21551071^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043229	intracellular organelle	PMID:10340764^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031340	positive regulation of vesicle fusion	PMID:18508778^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031045	dense core granule	PMID:21551071^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031045	dense core granule	PMID:11751925^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	PMID:15015935^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0017158	regulation of calcium ion-dependent exocytosis	PMID:17686463^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0017158	regulation of calcium ion-dependent exocytosis	PMID:11751925^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0017075	syntaxin-1 binding	PMID:22711810^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071277	cellular response to calcium ion	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000001283 RGD:3803	P		Seeded From UniProt	complete
part_of	GO:0070382	exocytic vesicle	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1859546 PANTHER:PTN000001284 RGD:68397	C		Seeded From UniProt	complete
involved_in	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004242 PANTHER:PTN000797569	P		Seeded From UniProt	complete
involved_in	GO:0048488	synaptic vesicle endocytosis	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004242 PANTHER:PTN000797569	P		Seeded From UniProt	complete
part_of	GO:0031045	dense core granule	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1926368 MGI:MGI:99667 PANTHER:PTN000740739 RGD:3803 WB:WBGene00004922	C		Seeded From UniProt	complete
part_of	GO:0030672	synaptic vesicle membrane	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99667 PANTHER:PTN000740739 RGD:3803	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99666 MGI:MGI:99667 PANTHER:PTN000740739	C		Seeded From UniProt	complete
enables	GO:0030276	clathrin binding	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000001283 RGD:3803 RGD:3805 RGD:3806 RGD:68397 RGD:68399 UniProtKB:Q5T7P8	F		Seeded From UniProt	complete
enables	GO:0019905	syntaxin binding	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000797569 RGD:3803 RGD:3804 RGD:3806 RGD:68399	F		Seeded From UniProt	complete
enables	GO:0019905	syntaxin binding	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000797569 RGD:3803 RGD:3804 RGD:3806	F		Seeded From UniProt	complete
involved_in	GO:0017158	regulation of calcium ion-dependent exocytosis	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101759 MGI:MGI:1859545 MGI:MGI:1859546 MGI:MGI:1926368 MGI:MGI:1926373 MGI:MGI:99666 MGI:MGI:99667 PANTHER:PTN000001283 RGD:3803 RGD:3805 RGD:62013 RGD:621169 RGD:68397	P		Seeded From UniProt	complete
involved_in	GO:0017156	calcium ion regulated exocytosis	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000001283 RGD:62013	P		Seeded From UniProt	complete
involved_in	GO:0016192	vesicle-mediated transport	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004242 MGI:MGI:1933945 PANTHER:PTN000001284	P		Seeded From UniProt	complete
involved_in	GO:0016079	synaptic vesicle exocytosis	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99667 PANTHER:PTN000797569	P		Seeded From UniProt	complete
involved_in	GO:0014059	regulation of dopamine secretion	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101759 MGI:MGI:1859545 MGI:MGI:99667 PANTHER:PTN000001283	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0261089 MGI:MGI:101759 MGI:MGI:1859544 MGI:MGI:99666 PANTHER:PTN000001284 RGD:3803 RGD:62013 UniProtKB:Q9H2B2	C		Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004242 FB:FBgn0028400 MGI:MGI:101759 MGI:MGI:1859544 MGI:MGI:1859545 MGI:MGI:1926368 MGI:MGI:99665 MGI:MGI:99666 MGI:MGI:99667 PANTHER:PTN000001283 RGD:3803 RGD:3804 RGD:3805 RGD:3806 RGD:62013 RGD:62042 RGD:68397 RGD:68399 UniProtKB:Q5T7P8	F		Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004242 FB:FBgn0028400 MGI:MGI:101759 MGI:MGI:1859544 MGI:MGI:1859545 MGI:MGI:1926368 MGI:MGI:99665 MGI:MGI:99666 MGI:MGI:99667 PANTHER:PTN000001283 RGD:3803 RGD:3804 RGD:3805 RGD:3806 RGD:62013	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004242 MGI:MGI:101759 MGI:MGI:1859546 MGI:MGI:99666 MGI:MGI:99667 PANTHER:PTN000001283 RGD:3803 UniProtKB:O00445	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004242 MGI:MGI:101759 MGI:MGI:1859546 MGI:MGI:99666 MGI:MGI:99667 PANTHER:PTN000001283 RGD:3803 RGD:62042 RGD:68397 UniProtKB:O00445	F		Seeded From UniProt	complete
enables	GO:0001786	phosphatidylserine binding	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004242 FB:FBgn0028400 MGI:MGI:1859544 MGI:MGI:1859545 MGI:MGI:1859546 MGI:MGI:1926368 MGI:MGI:1926373 MGI:MGI:99666 PANTHER:PTN000001283 RGD:3803 RGD:3805 RGD:68397	F		Seeded From UniProt	complete
enables	GO:0001786	phosphatidylserine binding	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004242 FB:FBgn0028400 MGI:MGI:1859544 MGI:MGI:1859545 MGI:MGI:1859546 MGI:MGI:1926368 MGI:MGI:1926373 MGI:MGI:99666 PANTHER:PTN000001283 RGD:3803 RGD:3805	F		Seeded From UniProt	complete
enables	GO:0000149	SNARE binding	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004242 FB:FBgn0028400 MGI:MGI:1859545 MGI:MGI:1859546 MGI:MGI:1859547 MGI:MGI:1926368 MGI:MGI:1926373 PANTHER:PTN000001283 RGD:3803 RGD:3805 RGD:68397	F		Seeded From UniProt	complete
part_of	GO:0031045	dense core granule	PMID:22366033^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10967100^[31]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:9830048^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P21707	F		Seeded From UniProt	complete
involved_in	GO:1903861	positive regulation of dendrite extension	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21579 ensembl:ENSP00000261205	P		Seeded From UniProt	complete
enables	GO:0050750	low-density lipoprotein particle receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21579 ensembl:ENSP00000261205	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21579 ensembl:ENSP00000261205	C		Seeded From UniProt	complete
involved_in	GO:0099502	calcium-dependent activation of synaptic vesicle fusion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46096 ensembl:ENSMUSP00000100912	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46096 ensembl:ENSMUSP00000100912	C		Seeded From UniProt	complete
involved_in	GO:0098746	fast, calcium ion-dependent exocytosis of neurotransmitter	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46096 ensembl:ENSMUSP00000100912	P		Seeded From UniProt	complete
involved_in	GO:0051966	regulation of synaptic transmission, glutamatergic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46096 ensembl:ENSMUSP00000100912	P		Seeded From UniProt	complete
involved_in	GO:0050806	positive regulation of synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46096 ensembl:ENSMUSP00000100912	P		Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46096 ensembl:ENSMUSP00000100912	F		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46096 ensembl:ENSMUSP00000100912	C		Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46096 ensembl:ENSMUSP00000100912	C		Seeded From UniProt	complete
part_of	GO:0031045	dense core granule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46096 ensembl:ENSMUSP00000100912	C		Seeded From UniProt	complete
part_of	GO:0030672	synaptic vesicle membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46096 ensembl:ENSMUSP00000100912	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46096 ensembl:ENSMUSP00000100912	C		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46096 ensembl:ENSMUSP00000100912	C		Seeded From UniProt	complete
involved_in	GO:0017158	regulation of calcium ion-dependent exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46096 ensembl:ENSMUSP00000100912	P		Seeded From UniProt	complete
enables	GO:0017075	syntaxin-1 binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46096 ensembl:ENSMUSP00000100912	F		Seeded From UniProt	complete
involved_in	GO:0016079	synaptic vesicle exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46096 ensembl:ENSMUSP00000100912	P		Seeded From UniProt	complete
involved_in	GO:0014059	regulation of dopamine secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46096 ensembl:ENSMUSP00000100912	P		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46096 ensembl:ENSMUSP00000100912	C		Seeded From UniProt	complete
involved_in	GO:0007269	neurotransmitter secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46096 ensembl:ENSMUSP00000100912	P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46096 ensembl:ENSMUSP00000100912	C		Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46096 ensembl:ENSMUSP00000100912	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46096 ensembl:ENSMUSP00000100912	F		Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015428	F		Seeded From UniProt	complete
involved_in	GO:0007269	neurotransmitter secretion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015428	P		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015428	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001565	C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:10397765^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:2333096^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:2333096^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0030672	synaptic vesicle membrane	PMID:2333096^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0017156	calcium ion regulated exocytosis	PMID:2333096^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016079	synaptic vesicle exocytosis	PMID:2333096^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
part_of	GO:0042584	chromaffin granule membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0062	C		Seeded From UniProt	complete
part_of	GO:0030672	synaptic vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0260	C		Seeded From UniProt	complete
part_of	GO:0030658	transport vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0245	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Dai, Z et al. (2017) Rab3A Inhibition of Ca -Dependent Dopamine Release From PC12 Cells Involves Interaction With Synaptotagmin I. J. Cell. Biochem. 118 3696-3705 PubMed GONUTS page
↑ Li, H et al. (2013) A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. Nat. Cell Biol. 15 773-85 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Chapman, ER et al. (1998) Delineation of the oligomerization, AP-2 binding, and synprint binding region of the C2B domain of synaptotagmin. J. Biol. Chem. 273 32966-72 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Thomas, DM et al. (1999) Functional and biochemical analysis of the C2 domains of synaptotagmin IV. Mol. Biol. Cell 10 2285-95 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Wang, Z & Chapman, ER (2010) Rat and Drosophila synaptotagmin 4 have opposite effects during SNARE-catalyzed membrane fusion. J. Biol. Chem. 285 30759-66 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Tucker, WC et al. (2003) Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells. J. Cell Biol. 162 199-209 PubMed GONUTS page
↑ ^7.0 ^7.1 Takamori, S et al. (2006) Molecular anatomy of a trafficking organelle. Cell 127 831-46 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Shin, OH et al. (2003) Sr2+ binding to the Ca2+ binding site of the synaptotagmin 1 C2B domain triggers fast exocytosis without stimulating SNARE interactions. Neuron 37 99-108 PubMed GONUTS page
↑ Wilhelm, BG et al. (2014) Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Science 344 1023-8 PubMed GONUTS page
↑ Davletov, BA & Südhof, TC (1993) A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding. J. Biol. Chem. 268 26386-90 PubMed GONUTS page
↑ Yun, HJ et al. (2013) LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25. Exp. Mol. Med. 45 e36 PubMed GONUTS page
↑ Ko, J et al. (2009) Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation. EMBO J. 28 3244-55 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Li, C et al. (1995) Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins. Nature 375 594-9 PubMed GONUTS page
↑ ^14.0 ^14.1 Bakkaloglu, B et al. (2008) Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders. Am. J. Hum. Genet. 82 165-73 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 Matthew, WD et al. (1981) Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecretory tissue. J. Cell Biol. 91 257-69 PubMed GONUTS page
↑ ^16.0 ^16.1 Tokumaru, H et al. (2008) Direct interaction of SNARE complex binding protein synaphin/complexin with calcium sensor synaptotagmin 1. Brain Cell Biol 36 173-89 PubMed GONUTS page
↑ Tocco, G et al. (1996) Two synaptotagmin genes, Syt1 and Syt4, are differentially regulated in adult brain and during postnatal development following kainic acid-induced seizures. Brain Res. Mol. Brain Res. 40 229-39 PubMed GONUTS page
↑ ^18.0 ^18.1 van den Bogaart, G et al. (2012) Phosphatidylinositol 4,5-bisphosphate increases Ca2+ affinity of synaptotagmin-1 by 40-fold. J. Biol. Chem. 287 16447-53 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 Vennekate, W et al. (2012) Cis- and trans-membrane interactions of synaptotagmin-1. Proc. Natl. Acad. Sci. U.S.A. 109 11037-42 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 ^20.4 ^20.5 ^20.6 Perin, MS et al. (1990) Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C. Nature 345 260-3 PubMed GONUTS page
↑ ^21.0 ^21.1 Lai, Y & Shin, YK (2012) The importance of an asymmetric distribution of acidic lipids for synaptotagmin 1 function as a Ca2+ sensor. Biochem. J. 443 223-9 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 Zhang, Z et al. (2011) Release mode of large and small dense-core vesicles specified by different synaptotagmin isoforms in PC12 cells. Mol. Biol. Cell 22 2324-36 PubMed GONUTS page
↑ Cheng, Y et al. (2004) Crystallographic identification of Ca2+ and Sr2+ coordination sites in synaptotagmin I C2B domain. Protein Sci. 13 2665-72 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 Bhalla, A et al. (2008) Analysis of the synaptotagmin family during reconstituted membrane fusion. Uncovering a class of inhibitory isoforms. J. Biol. Chem. 283 21799-807 PubMed GONUTS page
↑ Maienschein, V et al. (1999) A plethora of presynaptic proteins associated with ATP-storing organelles in cultured astrocytes. Glia 26 233-44 PubMed GONUTS page
↑ ^26.0 ^26.1 Fukuda, M et al. (2002) Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells. J. Biol. Chem. 277 4601-4 PubMed GONUTS page
↑ Fukuda, M (2004) RNA interference-mediated silencing of synaptotagmin IX, but not synaptotagmin I, inhibits dense-core vesicle exocytosis in PC12 cells. Biochem. J. 380 875-9 PubMed GONUTS page
↑ Zhu, D et al. (2007) Synaptotagmin I and IX function redundantly in controlling fusion pore of large dense core vesicles. Biochem. Biophys. Res. Commun. 361 922-7 PubMed GONUTS page
↑ ^29.00 ^29.01 ^29.02 ^29.03 ^29.04 ^29.05 ^29.06 ^29.07 ^29.08 ^29.09 ^29.10 ^29.11 ^29.12 ^29.13 ^29.14 ^29.15 ^29.16 ^29.17 ^29.18 ^29.19 ^29.20 ^29.21 ^29.22 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Hayashi, T et al. (2012) Subcellular localization and putative role of VPS13A/chorein in dopaminergic neuronal cells. Biochem. Biophys. Res. Commun. 419 511-6 PubMed GONUTS page
↑ Harada, A et al. (2000) Nadrin, a novel neuron-specific GTPase-activating protein involved in regulated exocytosis. J. Biol. Chem. 275 36885-91 PubMed GONUTS page

[PMID:28370453-1] Dai, Z et al. (2017) Rab3A Inhibition of Ca -Dependent Dopamine Release From PC12 Cells Involves Interaction With Synaptotagmin I. J. Cell. Biochem. 118 3696-3705 PubMed GONUTS page

[PMID:23792689-2] Li, H et al. (2013) A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. Nat. Cell Biol. 15 773-85 PubMed GONUTS page

[PMID:9830048-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Chapman, ER et al. (1998) Delineation of the oligomerization, AP-2 binding, and synprint binding region of the C2B domain of synaptotagmin. J. Biol. Chem. 273 32966-72 PubMed GONUTS page

[PMID:10397765-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Thomas, DM et al. (1999) Functional and biochemical analysis of the C2 domains of synaptotagmin IV. Mol. Biol. Cell 10 2285-95 PubMed GONUTS page

[PMID:20688915-5] 5.0 ^5.1 ^5.2 ^5.3 Wang, Z & Chapman, ER (2010) Rat and Drosophila synaptotagmin 4 have opposite effects during SNARE-catalyzed membrane fusion. J. Biol. Chem. 285 30759-66 PubMed GONUTS page

[PMID:12860971-6] 6.0 ^6.1 ^6.2 ^6.3 Tucker, WC et al. (2003) Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells. J. Cell Biol. 162 199-209 PubMed GONUTS page

[PMID:17110340-7] 7.0 ^7.1 Takamori, S et al. (2006) Molecular anatomy of a trafficking organelle. Cell 127 831-46 PubMed GONUTS page

[PMID:12526776-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Shin, OH et al. (2003) Sr2+ binding to the Ca2+ binding site of the synaptotagmin 1 C2B domain triggers fast exocytosis without stimulating SNARE interactions. Neuron 37 99-108 PubMed GONUTS page

[PMID:24876496-9] Wilhelm, BG et al. (2014) Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Science 344 1023-8 PubMed GONUTS page

[PMID:8253763-10] Davletov, BA & Südhof, TC (1993) A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding. J. Biol. Chem. 268 26386-90 PubMed GONUTS page

[PMID:23949442-11] Yun, HJ et al. (2013) LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25. Exp. Mol. Med. 45 e36 PubMed GONUTS page

[PMID:19730411-12] Ko, J et al. (2009) Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation. EMBO J. 28 3244-55 PubMed GONUTS page

[PMID:7791877-13] 13.0 ^13.1 ^13.2 Li, C et al. (1995) Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins. Nature 375 594-9 PubMed GONUTS page

[PMID:18179895-14] 14.0 ^14.1 Bakkaloglu, B et al. (2008) Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders. Am. J. Hum. Genet. 82 165-73 PubMed GONUTS page

[PMID:7298720-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 Matthew, WD et al. (1981) Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecretory tissue. J. Cell Biol. 91 257-69 PubMed GONUTS page

[PMID:19132534-16] 16.0 ^16.1 Tokumaru, H et al. (2008) Direct interaction of SNARE complex binding protein synaphin/complexin with calcium sensor synaptotagmin 1. Brain Cell Biol 36 173-89 PubMed GONUTS page

[PMID:8872307-17] Tocco, G et al. (1996) Two synaptotagmin genes, Syt1 and Syt4, are differentially regulated in adult brain and during postnatal development following kainic acid-induced seizures. Brain Res. Mol. Brain Res. 40 229-39 PubMed GONUTS page

[PMID:22447935-18] 18.0 ^18.1 van den Bogaart, G et al. (2012) Phosphatidylinositol 4,5-bisphosphate increases Ca2+ affinity of synaptotagmin-1 by 40-fold. J. Biol. Chem. 287 16447-53 PubMed GONUTS page

[PMID:22711810-19] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 Vennekate, W et al. (2012) Cis- and trans-membrane interactions of synaptotagmin-1. Proc. Natl. Acad. Sci. U.S.A. 109 11037-42 PubMed GONUTS page

[PMID:2333096-20] 20.0 ^20.1 ^20.2 ^20.3 ^20.4 ^20.5 ^20.6 Perin, MS et al. (1990) Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C. Nature 345 260-3 PubMed GONUTS page

[PMID:22229667-21] 21.0 ^21.1 Lai, Y & Shin, YK (2012) The importance of an asymmetric distribution of acidic lipids for synaptotagmin 1 function as a Ca2+ sensor. Biochem. J. 443 223-9 PubMed GONUTS page

[PMID:21551071-22] 22.0 ^22.1 ^22.2 Zhang, Z et al. (2011) Release mode of large and small dense-core vesicles specified by different synaptotagmin isoforms in PC12 cells. Mol. Biol. Cell 22 2324-36 PubMed GONUTS page

[PMID:15340165-23] Cheng, Y et al. (2004) Crystallographic identification of Ca2+ and Sr2+ coordination sites in synaptotagmin I C2B domain. Protein Sci. 13 2665-72 PubMed GONUTS page

[PMID:18508778-24] 24.0 ^24.1 ^24.2 ^24.3 Bhalla, A et al. (2008) Analysis of the synaptotagmin family during reconstituted membrane fusion. Uncovering a class of inhibitory isoforms. J. Biol. Chem. 283 21799-807 PubMed GONUTS page

[PMID:10340764-25] Maienschein, V et al. (1999) A plethora of presynaptic proteins associated with ATP-storing organelles in cultured astrocytes. Glia 26 233-44 PubMed GONUTS page

[PMID:11751925-26] 26.0 ^26.1 Fukuda, M et al. (2002) Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells. J. Biol. Chem. 277 4601-4 PubMed GONUTS page

[PMID:15015935-27] Fukuda, M (2004) RNA interference-mediated silencing of synaptotagmin IX, but not synaptotagmin I, inhibits dense-core vesicle exocytosis in PC12 cells. Biochem. J. 380 875-9 PubMed GONUTS page

[PMID:17686463-28] Zhu, D et al. (2007) Synaptotagmin I and IX function redundantly in controlling fusion pore of large dense core vesicles. Biochem. Biophys. Res. Commun. 361 922-7 PubMed GONUTS page

[PMID:21873635-29] 29.00 ^29.01 ^29.02 ^29.03 ^29.04 ^29.05 ^29.06 ^29.07 ^29.08 ^29.09 ^29.10 ^29.11 ^29.12 ^29.13 ^29.14 ^29.15 ^29.16 ^29.17 ^29.18 ^29.19 ^29.20 ^29.21 ^29.22 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22366033-30] Hayashi, T et al. (2012) Subcellular localization and putative role of VPS13A/chorein in dopaminergic neuronal cells. Biochem. Biophys. Res. Commun. 419 511-6 PubMed GONUTS page

[PMID:10967100-31] Harada, A et al. (2000) Nadrin, a novel neuron-specific GTPase-activating protein involved in regulated exocytosis. J. Biol. Chem. 275 36885-91 PubMed GONUTS page

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RAT:SYT1

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