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RAT:SYGP1
Contents
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Syngap1 | |
| Protein Name(s) | Ras/Rap GTPase-activating protein SynGAP
Neuronal RasGAP Synaptic Ras GTPase-activating protein 1 Synaptic Ras-GAP 1 p135 SynGAP | |
| External Links | ||
| UniProt | Q9QUH6 | |
| EMBL | AF048976 AF053938 AF055883 AF058789 AF058790 AF050183 AB016962 | |
| PIR | T13958 T14259 T14270 | |
| UniGene | Rn.9908 | |
| PDB | 3BXJ | |
| PDBsum | 3BXJ | |
| ProteinModelPortal | Q9QUH6 | |
| SMR | Q9QUH6 | |
| IntAct | Q9QUH6 | |
| MINT | MINT-1778299 | |
| ChEMBL | CHEMBL2176804 | |
| PhosphoSite | Q9QUH6 | |
| PaxDb | Q9QUH6 | |
| PRIDE | Q9QUH6 | |
| UCSC | RGD:621090 | |
| RGD | 621090 | |
| eggNOG | NOG245428 | |
| HOVERGEN | HBG006492 | |
| InParanoid | Q9QUH6 | |
| PhylomeDB | Q9QUH6 | |
| EvolutionaryTrace | Q9QUH6 | |
| PRO | PR:Q9QUH6 | |
| Proteomes | UP000002494 | |
| Genevestigator | Q9QUH6 | |
| GO | GO:0030054 GO:0005737 GO:0031235 GO:0014069 GO:0019901 GO:0005099 GO:0046580 GO:0032320 GO:0048167 GO:0007165 | |
| Gene3D | 1.10.506.10 2.20.170.10 2.30.29.30 2.60.40.150 | |
| InterPro | IPR000008 IPR021887 IPR001849 IPR011993 IPR023152 IPR001936 IPR008936 IPR023315 | |
| Pfam | PF00168 PF12004 PF00616 | |
| SMART | SM00239 SM00233 SM00323 | |
| SUPFAM | SSF48350 SSF49562 | |
| PROSITE | PS50003 PS00509 PS50018 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0045202 |
synapse |
ECO:0000314 |
C |
Figure 5, C Two yeast two-hybrid bait constructs were tested for interaction with full-length PSD-95 as described in Experimental Procedures. The +QTRV construct interacts strongly, whereas the −QTRV construct does not. |
complete | |||||
|
part_of |
GO:0045202 |
synapse |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048167 |
regulation of synaptic plasticity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046580 |
negative regulation of Ras protein signal transduction |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019901 |
protein kinase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0099092 |
postsynaptic density, intracellular component |
ECO:0005589 |
confocal microscopy evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098978 |
glutamatergic synapse |
ECO:0005589 |
confocal microscopy evidence used in manual assertion |
C |
part_of:(UBERON:0002421) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046580 |
negative regulation of Ras protein signal transduction |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019901 |
protein kinase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
RGD:2261 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0014069 |
postsynaptic density |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0014069 |
postsynaptic density |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005096 |
GTPase activator activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005096 |
GTPase activator activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005096 |
GTPase activator activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043547 |
positive regulation of GTPase activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005096 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043547 |
positive regulation of GTPase activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005096 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043547 |
positive regulation of GTPase activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005096 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043547 |
positive regulation of GTPase activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005096 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043087 |
regulation of GTPase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046580 |
negative regulation of Ras protein signal transduction |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045202 |
synapse |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017124 |
SH3 domain binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030054 |
cell junction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005096 |
GTPase activator activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Chen, HJ et al. (1998) A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II. Neuron 20 895-904 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Lee, KJ et al. (2011) Requirement for Plk2 in orchestrated ras and rap signaling, homeostatic structural plasticity, and memory. Neuron 69 957-73 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Yang, Y et al. (2011) SynGAP moves out of the core of the postsynaptic density upon depolarization. Neuroscience 192 132-9 PubMed GONUTS page
- ↑ Song, B et al. (2003) Cerebral ischemia immediately increases serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP by calcium/calmodulin-dependent protein kinase II alpha in hippocampus of rats. Neurosci. Lett. 349 183-6 PubMed GONUTS page
- ↑ 5.0 5.1 Oh, JS et al. (2004) Regulation of the neuron-specific Ras GTPase-activating protein, synGAP, by Ca2+/calmodulin-dependent protein kinase II. J. Biol. Chem. 279 17980-8 PubMed GONUTS page
- ↑ Rockliffe, N & Gawler, D (2006) Differential mechanisms of glutamate receptor regulation of SynGAP in cortical neurones. FEBS Lett. 580 831-8 PubMed GONUTS page
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