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RAT:STX2

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Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Stx2 (synonyms: Epim)
Protein Name(s) Syntaxin-2

Epimorphin

External Links
UniProt P50279
EMBL L20823
L20889
L20888
AH006759
PIR C48213
RefSeq NP_036880.1
XP_006249312.1
UniGene Rn.10623
ProteinModelPortal P50279
SMR P50279
BioGrid 247200
CORUM P50279
DIP DIP-347N
MINT MINT-1509080
STRING 10116.ENSRNOP00000001242
iPTMnet P50279
PhosphoSitePlus P50279
PaxDb P50279
PRIDE P50279
GeneID 25130
KEGG rno:25130
UCSC RGD:2558
CTD 2054
RGD 2558
eggNOG KOG0810
COG5074
HOGENOM HOG000286023
HOVERGEN HBG000497
InParanoid P50279
KO K08486
PhylomeDB P50279
PRO PR:P50279
Proteomes UP000002494
Genevisible P50279
GO GO:0016021
GO:0030496
GO:0005886
GO:0031201
GO:0008021
GO:0030133
GO:0005484
GO:0000149
GO:0007340
GO:0048546
GO:0030855
GO:0006886
GO:0046907
GO:0030033
GO:0031629
GO:0048278
GO:0006906
GO:0006903
GO:0016192
InterPro IPR010989
IPR028671
IPR006012
IPR006011
IPR000727
PANTHER PTHR19957:SF36
Pfam PF05739
PF00804
SMART SM00503
SM00397
SUPFAM SSF47661
PROSITE PS00914
PS50192

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0000281

mitotic cytokinesis

PMID:12737809[1]

ECO:0000315

P

Rattus norvegicus, Syntaxin-2;

Syntaxin-2D can act as a dominant-negative inhibitor of the function of Syntaxin-2. In Figures 2B-2E, it is shown that when the function of Syntaxin-2 is inhibited, mitotic cytokinesis does not fully take place and the result is an increase in binucleated cells.

complete
CACAO 12977

part_of

GO:0045202

synapse

PMID:17110340[2]

ECO:0006064

cell-free assay evidence used in manual assertion

C

part_of:(UBERON:0000955)

Seeded From UniProt

complete

GO:0061952

midbody abscission

PMID:12737809[1]

ECO:0000315

P

Rattus norvegicus, Syntaxin-2;

Syntaxin-2D can act as a dominant-negative inhibitor of the function of Syntaxin-2. In Figure 2C, it is shown that when Syntaxin-2D is present, everything that should take place for cytokinesis is indistinguishable from the control except for midbody abscission, indicating that syntaxin-2 is involved in midbody abscission.

complete
CACAO 12978

part_of

GO:0045202

synapse

PMID:17110340[2]

ECO:0006042

cell fractionation evidence used in manual assertion

C

part_of:(UBERON:0000955)

Seeded From UniProt

complete

part_of

GO:0045202

synapse

PMID:17110340[2]

ECO:0000279

western blot evidence used in manual assertion

C

part_of:(UBERON:0000955)

Seeded From UniProt

complete

involved_in

GO:0048546

digestive tract morphogenesis

PMID:12464668[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030855

epithelial cell differentiation

PMID:12464668[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0030496

midbody

PMID:12737809[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0030133

transport vesicle

PMID:14578858[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030033

microvillus assembly

PMID:12464668[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0000149

SNARE binding

PMID:10564647[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0048787

presynaptic active zone membrane

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000461527
RGD:3784
RGD:69430

C

Seeded From UniProt

complete

involved_in

GO:0048278

vesicle docking

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000461349
SGD:S000005632

P

Seeded From UniProt

complete

part_of

GO:0042734

presynaptic membrane

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103077
PANTHER:PTN000461527
RGD:3784
RGD:69430

C

Seeded From UniProt

complete

involved_in

GO:0031629

synaptic vesicle fusion to presynaptic active zone membrane

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0013343
MGI:MGI:1930705
PANTHER:PTN000461527
RGD:69430

P

Seeded From UniProt

complete

part_of

GO:0031201

SNARE complex

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0013343
FB:FBgn0035540
MGI:MGI:103077
MGI:MGI:893577
PANTHER:PTN000461349
RGD:61917
RGD:619747
RGD:621005
RGD:621019
RGD:68426
SGD:S000002876
SGD:S000003180
SGD:S000004016
SGD:S000005378
SGD:S000005632
SGD:S000006153
UniProtKB:O14662
UniProtKB:O43752
UniProtKB:P56962
UniProtKB:Q12846
UniProtKB:Q16623
UniProtKB:Q86Y82
dictyBase:DDB_G0275429

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0031106
PANTHER:PTN000461349
RGD:61915
SGD:S000004016

C

Seeded From UniProt

complete

part_of

GO:0012505

endomembrane system

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000461349
TAIR:locus:2025620

C

Seeded From UniProt

complete

part_of

GO:0008021

synaptic vesicle

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0013343
MGI:MGI:103077
MGI:MGI:109355
PANTHER:PTN000461527

C

Seeded From UniProt

complete

involved_in

GO:0006906

vesicle fusion

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0013343
MGI:MGI:103077
PANTHER:PTN000461349
RGD:61917
RGD:619747
SGD:S000002876
SGD:S000003180
SGD:S000004016
SGD:S000005378
SGD:S000005632
SGD:S000006153
UniProtKB:O43752
dictyBase:DDB_G0275429
dictyBase:DDB_G0287733

P

Seeded From UniProt

complete

involved_in

GO:0006887

exocytosis

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103077
PANTHER:PTN000461524

P

Seeded From UniProt

complete

involved_in

GO:0006886

intracellular protein transport

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000461349
UniProtKB:Q946Y7

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109355
MGI:MGI:1930705
MGI:MGI:893577
PANTHER:PTN000461524
PomBase:SPCC825.03c
RGD:621005
RGD:621019
RGD:69430
SGD:S000004795
SGD:S000006153
TAIR:locus:2025620
TAIR:locus:2079449
TAIR:locus:2079894
TAIR:locus:2081476
TAIR:locus:2197749
UniProtKB:O96189
UniProtKB:P32856
UniProtKB:Q12846
UniProtKB:Q13277
UniProtKB:Q16623
UniProtKB:Q8VZU2
WB:WBGene00006371

C

Seeded From UniProt

complete

enables

GO:0005484

SNAP receptor activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0011708
FB:FBgn0013343
FB:FBgn0031106
FB:FBgn0035540
PANTHER:PTN000461349
RGD:619747
RGD:621005
RGD:621019
SGD:S000000012
SGD:S000002876
SGD:S000003180
SGD:S000004016
SGD:S000004795
SGD:S000005378
SGD:S000005562
SGD:S000005632
SGD:S000006153
TAIR:locus:2148960
UniProtKB:O14662
UniProtKB:P56962
UniProtKB:Q13190

F

Seeded From UniProt

complete

enables

GO:0000149

SNARE binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0013343
FB:FBgn0035540
MGI:MGI:109355
MGI:MGI:893577
PANTHER:PTN000461349
RGD:2558
RGD:619747
RGD:621019
RGD:69430
RGD:708499
UniProtKB:O15400
UniProtKB:P56962

F

Seeded From UniProt

complete

enables

GO:0005484

SNAP receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006012

F

Seeded From UniProt

complete

involved_in

GO:0006886

intracellular protein transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006012

P

Seeded From UniProt

complete

involved_in

GO:0007340

acrosome reaction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028671

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006011
InterPro:IPR006012
InterPro:IPR010989

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028671

C

Seeded From UniProt

complete

involved_in

GO:0016192

vesicle-mediated transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010989

P

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028671

P

Seeded From UniProt

complete

involved_in

GO:0046907

intracellular transport

PMID:10564647[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016192

vesicle-mediated transport

PMID:10564647[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:10564647[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006906

vesicle fusion

PMID:8938452[7]
PMID:10564647[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

involved_in

GO:0006903

vesicle targeting

PMID:8938452[7]
PMID:10564647[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Low, SH et al. (2003) Syntaxin 2 and endobrevin are required for the terminal step of cytokinesis in mammalian cells. Dev. Cell 4 753-9 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Takamori, S et al. (2006) Molecular anatomy of a trafficking organelle. Cell 127 831-46 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Fritsch, C et al. (2002) Epimorphin expression in intestinal myofibroblasts induces epithelial morphogenesis. J. Clin. Invest. 110 1629-41 PubMed GONUTS page
  4. ↑ Larkin, JM et al. (2003) Intracellular accumulation of pIgA-R and regulators of transcytotic trafficking in cholestatic rat hepatocytes. Hepatology 38 1199-209 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 Quiñones, B et al. (1999) Syntaxin 2 splice variants exhibit differential expression patterns, biochemical properties and subcellular localizations. J. Cell. Sci. 112 ( Pt 23) 4291-304 PubMed GONUTS page
  6. ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 6.11 6.12 6.13 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  7. ↑ 7.0 7.1 Zha, H et al. (1996) The epimorphin gene is highly conserved among humans, mice, and rats and maps to human chromosome 7, mouse chromosome 5, and rat chromosome 12. Genomics 37 386-9 PubMed GONUTS page
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