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RAT:SMS

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Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Sst (synonyms: Smst)
Protein Name(s) Somatostatin

Antrin Somatostatin-28 Somatostatin-14

External Links
UniProt P60042
EMBL K02248
V01271
J00787
M25890
J00788
PIR A20983
RefSeq NP_036791.1
UniGene Rn.34418
ProteinModelPortal P60042
BindingDB P60042
PaxDb P60042
Ensembl ENSRNOT00000002519
GeneID 24797
KEGG rno:24797
UCSC RGD:3761
CTD 6750
RGD 3761
eggNOG NOG44503
GeneTree ENSGT00510000047914
HOGENOM HOG000036630
HOVERGEN HBG017816
InParanoid P60042
KO K05237
OMA RMELQRS
OrthoDB EOG7H4DXK
PhylomeDB P60042
TreeFam TF333185
Reactome REACT_233455
REACT_250028
NextBio 604448
PMAP-CutDB P60042
PRO PR:P60042
Proteomes UP000002494
Genevestigator P60042
GO GO:0005615
GO:0043025
GO:0005179
GO:0006972
GO:0030334
GO:0010447
GO:0043200
GO:0042493
GO:0009408
GO:0010243
GO:0048545
InterPro IPR004250
IPR018142
PANTHER PTHR10558
Pfam PF03002
PIRSF PIRSF001814

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005179

hormone activity

PMID:6120163[1]

ECO:0000314

F

Figure 2 shows the specific nucleotides used for transcribing the gene somatostatin within the rat's DNA, so that it can later be used as a regulator of both pancreatic and gastrointestinal hormones.

complete
CACAO 9312

involved_in

GO:0048545

response to steroid hormone

PMID:18421448[2]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043200

response to amino acid

PMID:17961553[3]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

PMID:18598846[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

PMID:18800063[5]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010447

response to acidic pH

PMID:18992283[6]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010243

response to organonitrogen compound

PMID:17961553[3]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009408

response to heat

PMID:18785410[7]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006972

hyperosmotic response

PMID:18992283[6]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:18992283[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030334

regulation of cell migration

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98326
PANTHER:PTN000059370

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98326
PANTHER:PTN000059370
RGD:3761

C

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0030334

regulation of cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P60041
ensembl:ENSMUSP00000004480

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P60041
ensembl:ENSMUSP00000004480

C

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004250
InterPro:IPR018142

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004250
InterPro:IPR018142

C

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

PMID:2861199[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0372

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Goodman, RH et al. (1982) Somatostatin-28 encoded in a cloned cDNA obtained from a rat medullary thyroid carcinoma. J. Biol. Chem. 257 1156-9 PubMed GONUTS page
  2. Van Vugt, HH et al. (2008) Somatostatin in the rat periventricular nucleus: sex differences and effect of gonadal steroids. Exp Brain Res 188 483-91 PubMed GONUTS page
  3. 3.0 3.1 Kiagiadaki, F et al. (2008) Dopamine (D1) receptor activation and nitrinergic agents influence somatostatin levels in rat retina. Exp. Eye Res. 86 18-24 PubMed GONUTS page
  4. Kowiański, P et al. (2008) NPY-, SOM- and VIP-containing interneurons in postnatal development of the rat claustrum. Brain Res. Bull. 76 565-71 PubMed GONUTS page
  5. Pallis, E et al. (2009) Antidepressants influence somatostatin levels and receptor pharmacology in brain. Neuropsychopharmacology 34 952-63 PubMed GONUTS page
  6. 6.0 6.1 6.2 Rudholm, T et al. (2009) Release of regulatory gut peptides somatostatin, neurotensin and vasoactive intestinal peptide by acid and hyperosmolal solutions in the intestine in conscious rats. Regul. Pept. 152 8-12 PubMed GONUTS page
  7. Guo, X et al. (2008) [Effect of rheum on gastrointestinal hormones in rats with severe scald injury]. Zhonghua Shao Shang Za Zhi 24 111-3 PubMed GONUTS page
  8. 8.0 8.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  9. Hayes, TE & Dixon, JE (1985) Z-DNA in the rat somatostatin gene. J. Biol. Chem. 260 8145-56 PubMed GONUTS page