RAT:SLIT2

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Slit2
Protein Name(s)	Slit homolog 2 protein Slit-2
External Links
UniProt	Q9WVC1
EMBL	AF141386
UniGene	Rn.146652
ProteinModelPortal	Q9WVC1
SMR	Q9WVC1
IntAct	Q9WVC1
STRING	10116.ENSRNOP00000005477
PaxDb	Q9WVC1
PRIDE	Q9WVC1
RGD	69310
eggNOG	COG4886
HOGENOM	HOG000170672
HOVERGEN	HBG057959
InParanoid	Q9WVC1
PhylomeDB	Q9WVC1
PRO	PR:Q9WVC1
Proteomes	UP000002494
Genevestigator	Q9WVC1
GO	GO:0005576 GO:0016021 GO:0005886 GO:0004963 GO:0043395 GO:0008201 GO:0007420 GO:0030154 GO:0006935 GO:0050728 GO:0090027 GO:0031667 GO:0021510
InterPro	IPR000483 IPR002272 IPR001611 IPR003591 IPR000372
Pfam	PF00560 PF13855 PF01463 PF01462
PRINTS	PR01143
SMART	SM00369 SM00082 SM00013
PROSITE	PS51450

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0005886	plasma membrane	PMID:19783284^[1]	ECO:0000314			C		complete
	GO:0031667	response to nutrient levels	PMID:16497807^[2]	ECO:0000270			P		complete
	GO:0050728	negative regulation of inflammatory response	PMID:15215188^[3]	ECO:0000315			P		complete
	GO:0007420	brain development	PMID:11754167^[4]	ECO:0000270			P		complete
	GO:0043395	heparan sulfate proteoglycan binding	PMID:10364234^[5]	ECO:0000314			F		complete
	GO:0021510	spinal cord development	PMID:10102268^[6]	ECO:0000270			P		complete
involved_in	GO:0090027	negative regulation of monocyte chemotaxis	PMID:15528323^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	PMID:15215188^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0043395	heparan sulfate proteoglycan binding	PMID:10364234^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0031667	response to nutrient levels	PMID:16497807^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0021510	spinal cord development	PMID:10102268^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007420	brain development	PMID:11754167^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:19783284^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0031290	retinal ganglion cell axon guidance	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1315205 PANTHER:PTN000690516 UniProtKB:O94813	P	Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000690516 UniProtKB:O94813	P	Seeded From UniProt	complete
involved_in	GO:0042699	follicle-stimulating hormone signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004963	P	Seeded From UniProt	complete
enables	GO:0004963	follicle-stimulating hormone receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002272	F	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002272	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002272	C	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0145	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Liu, JB et al. (2011) Expression of Slit2 and Robo1 after traumatic lesions of the rat spinal cord. Acta Histochem. 113 43-8 PubMed GONUTS page
↑ ^2.0 ^2.1 Molendi-Coste, O et al. (2006) Maternal perinatal undernutrition alters neuronal and neuroendocrine differentiation in the rat adrenal medulla at weaning. Endocrinology 147 3050-9 PubMed GONUTS page
↑ ^3.0 ^3.1 Kanellis, J et al. (2004) Modulation of inflammation by slit protein in vivo in experimental crescentic glomerulonephritis. Am. J. Pathol. 165 341-52 PubMed GONUTS page
↑ ^4.0 ^4.1 Marillat, V et al. (2002) Spatiotemporal expression patterns of slit and robo genes in the rat brain. J. Comp. Neurol. 442 130-55 PubMed GONUTS page
↑ ^5.0 ^5.1 Liang, Y et al. (1999) Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain. J. Biol. Chem. 274 17885-92 PubMed GONUTS page
↑ ^6.0 ^6.1 Brose, K et al. (1999) Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. Cell 96 795-806 PubMed GONUTS page
↑ Chen, B et al. (2004) Cutting edge: bone morphogenetic protein antagonists Drm/Gremlin and Dan interact with Slits and act as negative regulators of monocyte chemotaxis. J. Immunol. 173 5914-7 PubMed GONUTS page
↑ ^8.0 ^8.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19783284-1] 1.0 ^1.1 Liu, JB et al. (2011) Expression of Slit2 and Robo1 after traumatic lesions of the rat spinal cord. Acta Histochem. 113 43-8 PubMed GONUTS page

[PMID:16497807-2] 2.0 ^2.1 Molendi-Coste, O et al. (2006) Maternal perinatal undernutrition alters neuronal and neuroendocrine differentiation in the rat adrenal medulla at weaning. Endocrinology 147 3050-9 PubMed GONUTS page

[PMID:15215188-3] 3.0 ^3.1 Kanellis, J et al. (2004) Modulation of inflammation by slit protein in vivo in experimental crescentic glomerulonephritis. Am. J. Pathol. 165 341-52 PubMed GONUTS page

[PMID:11754167-4] 4.0 ^4.1 Marillat, V et al. (2002) Spatiotemporal expression patterns of slit and robo genes in the rat brain. J. Comp. Neurol. 442 130-55 PubMed GONUTS page

[PMID:10364234-5] 5.0 ^5.1 Liang, Y et al. (1999) Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain. J. Biol. Chem. 274 17885-92 PubMed GONUTS page

[PMID:10102268-6] 6.0 ^6.1 Brose, K et al. (1999) Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. Cell 96 795-806 PubMed GONUTS page

[PMID:15528323-7] Chen, B et al. (2004) Cutting edge: bone morphogenetic protein antagonists Drm/Gremlin and Dan interact with Slits and act as negative regulators of monocyte chemotaxis. J. Immunol. 173 5914-7 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:SLIT2

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