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RAT:SLIT1
Contents
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Slit1 (synonyms: Megf4) | |
| Protein Name(s) | Slit homolog 1 protein
Slit-1 Multiple epidermal growth factor-like domains protein 4 Multiple EGF-like domains protein 4 | |
| External Links | ||
| UniProt | O88279 | |
| EMBL | AB011530 AF133730 AB073213 AB073214 AB073215 AB017170 | |
| PIR | T42218 | |
| RefSeq | NP_075242.1 | |
| UniGene | Rn.30002 | |
| ProteinModelPortal | O88279 | |
| SMR | O88279 | |
| PaxDb | O88279 | |
| PRIDE | O88279 | |
| GeneID | 65047 | |
| KEGG | rno:65047 | |
| UCSC | RGD:69307 | |
| CTD | 6585 | |
| RGD | 69307 | |
| eggNOG | COG4886 | |
| HOGENOM | HOG000116120 | |
| HOVERGEN | HBG057959 | |
| InParanoid | O88279 | |
| KO | K06838 | |
| PhylomeDB | O88279 | |
| Reactome | REACT_252640 | |
| NextBio | 613884 | |
| PRO | PR:O88279 | |
| Proteomes | UP000002494 | |
| ExpressionAtlas | O88279 | |
| Genevestigator | O88279 | |
| GO | GO:0005615 GO:0005509 GO:0043395 GO:0048846 GO:0007420 GO:0033563 GO:0040023 GO:0008045 GO:0050919 GO:0048843 GO:0051964 GO:0031290 GO:0021510 GO:0022028 | |
| Gene3D | 2.60.120.200 | |
| InterPro | IPR013320 IPR000483 IPR006207 IPR000742 IPR001881 IPR013032 IPR000152 IPR018097 IPR003645 IPR009030 IPR001791 IPR001611 IPR003591 IPR000372 | |
| Pfam | PF00008 PF12661 PF02210 PF00560 PF13855 PF01463 PF01462 | |
| SMART | SM00041 SM00181 SM00179 SM00274 SM00282 SM00369 SM00082 SM00013 | |
| SUPFAM | SSF49899 SSF57184 | |
| PROSITE | PS01185 PS01225 PS00022 PS01186 PS50026 PS01187 PS50025 PS51450 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0007420 |
brain development |
ECO:0000270 |
P |
complete | ||||||
| GO:0021510 |
spinal cord development |
ECO:0000270 |
P |
complete | ||||||
| GO:0048843 |
negative regulation of axon extension involved in axon guidance |
ECO:0000314 |
P |
complete | ||||||
| GO:0005615 |
extracellular space |
ECO:0000314 |
C |
complete | ||||||
| GO:0043395 |
heparan sulfate proteoglycan binding |
ECO:0000314 |
F |
complete | ||||||
|
involved_in |
GO:0051964 |
negative regulation of synapse assembly |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048843 |
negative regulation of axon extension involved in axon guidance |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043395 |
heparan sulfate proteoglycan binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0021510 |
spinal cord development |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007420 |
brain development |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005509 |
calcium ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007399 |
nervous system development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Marillat, V et al. (2002) Spatiotemporal expression patterns of slit and robo genes in the rat brain. J. Comp. Neurol. 442 130-55 PubMed GONUTS page
- ↑ 2.0 2.1 Brose, K et al. (1999) Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. Cell 96 795-806 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Tanno, T et al. (2004) Expression and function of Slit1alpha, a novel alternative splicing product for slit1. J. Biochem. 136 575-81 PubMed GONUTS page
- ↑ 4.0 4.1 Liang, Y et al. (1999) Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain. J. Biol. Chem. 274 17885-92 PubMed GONUTS page
