RAT:SHAN3

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Shank3 (synonyms: Prosap2)
Protein Name(s)	SH3 and multiple ankyrin repeat domains protein 3 Shank3 Proline-rich synapse-associated protein 2 ProSAP2 SPANK-2
External Links
UniProt	Q9JLU4
EMBL	AF133301 AJ133120 AF159047
RefSeq	NP_067708.1
UniGene	Rn.42876
PDB	2F3N 2F44
PDBsum	2F3N 2F44
BioGrid	248756
IntAct	Q9JLU4
MINT	MINT-1486849
PhosphoSite	Q9JLU4
PaxDb	Q9JLU4
PRIDE	Q9JLU4
Ensembl	ENSRNOT00000045913
GeneID	59312
KEGG	rno:59312
CTD	85358
RGD	69264
eggNOG	COG0666
GeneTree	ENSGT00510000046474
HOGENOM	HOG000293276
HOVERGEN	HBG054027
InParanoid	Q9JLU4
KO	K15009
OrthoDB	EOG7GBFW2
EvolutionaryTrace	Q9JLU4
NextBio	611861
PRO	PR:Q9JLU4
Proteomes	UP000002494
Genevestigator	Q9JLU4
GO	GO:0030054 GO:0060170 GO:0005737 GO:0043197 GO:0043005 GO:0044309 GO:0097481 GO:0005886 GO:0014069 GO:0045211 GO:0045202 GO:0030160 GO:0042802 GO:0035255 GO:0008022 GO:0043621 GO:0097110 GO:0017124 GO:0008270 GO:0097113 GO:0048854 GO:0060997 GO:0097117 GO:0007612 GO:0035641 GO:0000165 GO:0007613 GO:0097114 GO:0032232 GO:0045794 GO:0050885 GO:2000969 GO:0060999 GO:2000463 GO:1900451 GO:0048170 GO:0051835 GO:0051968 GO:0097107 GO:0051259 GO:2000822 GO:0061001 GO:2000821 GO:1900452 GO:1900271 GO:0035176 GO:0021773 GO:0007416 GO:0071625
Gene3D	1.10.150.50 1.25.40.20 2.30.42.10
InterPro	IPR002110 IPR020683 IPR001478 IPR001660 IPR013761 IPR021129 IPR011511 IPR001452
Pfam	PF12796 PF00595 PF00536 PF07653
SMART	SM00248 SM00228 SM00454 SM00326
SUPFAM	SSF47769 SSF48403 SSF50044 SSF50156
PROSITE	PS50297 PS50088 PS50106 PS50105 PS50002

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0060170	cilium membrane	PMID:18596612^[1]	ECO:0000314			C		Subcellular fractionation, Figure 4 A and B showed from cilia fraction Shank3 located at the cilia membrane	complete CACAO 3197
involved_in	GO:0099562	maintenance of postsynaptic density structure	GO_REF:0000036	ECO:0000305	curator inference used in manual assertion	GO:0014069,GO:0030160	P		Seeded From UniProt	complete
enables	GO:0098919	structural constituent of postsynaptic density	GO_REF:0000036	ECO:0000305	curator inference used in manual assertion	GO:0014069,GO:0030160	F		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:15894489^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:1001571) part_of:(UBERON:0014554)	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:23719161^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0060170	ciliary membrane	PMID:18596612^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1900273	positive regulation of long-term synaptic potentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	P		Seeded From UniProt	complete
involved_in	GO:2000969	positive regulation of AMPA receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	P		Seeded From UniProt	complete
involved_in	GO:2000822	regulation of behavioral fear response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	P		Seeded From UniProt	complete
involved_in	GO:2000821	regulation of grooming behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	P		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	PMID:21795692^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	P		Seeded From UniProt	complete
involved_in	GO:1900452	regulation of long-term synaptic depression	PMID:21795692^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:1900451	positive regulation of glutamate receptor signaling pathway	PMID:21795692^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:1900271	regulation of long-term synaptic potentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:10433269^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0097117	guanylate kinase-associated protein clustering	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	P		Seeded From UniProt	complete
involved_in	GO:0097114	NMDA glutamate receptor clustering	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	P		Seeded From UniProt	complete
involved_in	GO:0097113	AMPA glutamate receptor clustering	PMID:21795692^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	PMID:10433269^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P97838	F		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	PMID:10433269^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9Z214	F		Seeded From UniProt	complete
involved_in	GO:0097107	postsynaptic density assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	P		Seeded From UniProt	complete
involved_in	GO:0071625	vocalization behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	P		Seeded From UniProt	complete
involved_in	GO:0061001	regulation of dendritic spine morphogenesis	PMID:21795692^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0060999	positive regulation of dendritic spine development	PMID:21795692^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0060997	dendritic spine morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	P		Seeded From UniProt	complete
part_of	GO:0060170	ciliary membrane	PMID:18596612^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051968	positive regulation of synaptic transmission, glutamatergic	PMID:21795692^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0051968	positive regulation of synaptic transmission, glutamatergic	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	P		Seeded From UniProt	complete
involved_in	GO:0051835	positive regulation of synapse structural plasticity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	P		Seeded From UniProt	complete
involved_in	GO:0050885	neuromuscular process controlling balance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	P		Seeded From UniProt	complete
involved_in	GO:0048854	brain morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	P		Seeded From UniProt	complete
involved_in	GO:0048170	positive regulation of long-term neuronal synaptic plasticity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	P		Seeded From UniProt	complete
involved_in	GO:0045794	negative regulation of cell volume	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	P	occurs_in:(CL:0002319) occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
part_of	GO:0044309	neuron spine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	C		Seeded From UniProt	complete
involved_in	GO:0035641	locomotory exploration behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	P		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	F		Seeded From UniProt	complete
involved_in	GO:0035176	social behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	P		Seeded From UniProt	complete
involved_in	GO:0032232	negative regulation of actin filament bundle assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	P		Seeded From UniProt	complete
enables	GO:0030160	GKAP/Homer scaffold activity	PMID:10433269^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0021773	striatal medium spiny neuron differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	P		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:10433269^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P97838	F		Seeded From UniProt	complete
involved_in	GO:0007613	memory	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	P		Seeded From UniProt	complete
involved_in	GO:0007612	learning	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	P		Seeded From UniProt	complete
involved_in	GO:0007416	synapse assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	P		Seeded From UniProt	complete
part_of	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	C	part_of:(GO:0044309) part_of:(CL:0010012)	Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4ACU6	P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:16522626^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0099092	postsynaptic density, intracellular component	PMID:15894489^[2]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0099092	postsynaptic density, intracellular component	PMID:15894489^[2]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0099092	postsynaptic density, intracellular component	PMID:15894489^[2]	ECO:0000279	western blot evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:23719161^[3]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:21217644^[7]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:21217644^[7]	ECO:0006052	RNAi evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:15894489^[2]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:10433269^[5]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(UBERON:0000955)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:23719161^[3]	ECO:0006004	super-resolution microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:21217644^[7]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:15894489^[2]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:21217644^[7]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:15894489^[2]	ECO:0000279	western blot evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:10433269^[5]	ECO:0000279	western blot evidence used in manual assertion		C	part_of:(UBERON:0000955)	Seeded From UniProt	complete
enables	GO:0098919	structural constituent of postsynaptic density	PMID:21217644^[7]	ECO:0006063	over expression analysis evidence used in manual assertion		F	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
enables	GO:0098919	structural constituent of postsynaptic density	PMID:21217644^[7]	ECO:0006052	RNAi evidence used in manual assertion		F	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
enables	GO:0098919	structural constituent of postsynaptic density	PMID:10433269^[5]	ECO:0006042	cell fractionation evidence used in manual assertion		F	occurs_in:(GO:0098978) occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
enables	GO:0098919	structural constituent of postsynaptic density	PMID:21217644^[7]	ECO:0006003	electron microscopy evidence used in manual assertion		F	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
enables	GO:0098919	structural constituent of postsynaptic density	PMID:21217644^[7]	ECO:0005589	confocal microscopy evidence used in manual assertion		F	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
enables	GO:0098919	structural constituent of postsynaptic density	PMID:10433269^[5]	ECO:0000279	western blot evidence used in manual assertion		F	occurs_in:(GO:0098978) occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:0050807	regulation of synapse organization	PMID:21217644^[7]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0050807	regulation of synapse organization	PMID:21217644^[7]	ECO:0006052	RNAi evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0050807	regulation of synapse organization	PMID:21217644^[7]	ECO:0006003	electron microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0050807	regulation of synapse organization	PMID:21217644^[7]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:23719161^[3]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:23719161^[3]	ECO:0006004	super-resolution microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:1900451	positive regulation of glutamate receptor signaling pathway	PMID:21795692^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051259	protein complex oligomerization	PMID:16439662^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:11509555^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0043621	protein self-association	PMID:16439662^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	PMID:15014124^[10]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:70941	F		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:16439662^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:15014124^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:16439662^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:10958799^[11]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:620768	F		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930016 MGI:MGI:3613677 PANTHER:PTN001191880	P		Seeded From UniProt	complete
involved_in	GO:2000311	regulation of AMPA receptor activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:3613677 PANTHER:PTN001191880	P		Seeded From UniProt	complete
involved_in	GO:0097107	postsynaptic density assembly	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930016 PANTHER:PTN001191880	P		Seeded From UniProt	complete
involved_in	GO:0060999	positive regulation of dendritic spine development	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930016 PANTHER:PTN001191880 RGD:621011	P		Seeded From UniProt	complete
involved_in	GO:0060997	dendritic spine morphogenesis	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930016 MGI:MGI:3613677 PANTHER:PTN001191880	P		Seeded From UniProt	complete
involved_in	GO:0060291	long-term synaptic potentiation	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930016 MGI:MGI:2671987 PANTHER:PTN001191880	P		Seeded From UniProt	complete
involved_in	GO:0051968	positive regulation of synaptic transmission, glutamatergic	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930016 MGI:MGI:2671987 PANTHER:PTN001191880	P		Seeded From UniProt	complete
involved_in	GO:0051124	synaptic growth at neuromuscular junction	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0040752 PANTHER:PTN001191880	P		Seeded From UniProt	complete
involved_in	GO:0048854	brain morphogenesis	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930016 PANTHER:PTN001191880 ZFIN:ZDB-GENE-060503-369	P		Seeded From UniProt	complete
colocalizes_with	GO:0045211	postsynaptic membrane	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2671987 MGI:MGI:3613677 PANTHER:PTN001191880 RGD:621011	C		Seeded From UniProt	complete
part_of	GO:0044309	neuron spine	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930016 PANTHER:PTN001191880	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2671987 MGI:MGI:3613677 PANTHER:PTN001191880 RGD:621011	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930016 MGI:MGI:2671987 MGI:MGI:3613677 PANTHER:PTN001191880	C		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930016 MGI:MGI:2671987 MGI:MGI:3613677 PANTHER:PTN001191878 RGD:621011	F		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:3613677 PANTHER:PTN001191880	C		Seeded From UniProt	complete
enables	GO:0030160	GKAP/Homer scaffold activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:3613677 PANTHER:PTN001191878 RGD:621011 RGD:69264	F		Seeded From UniProt	complete
enables	GO:0030159	receptor signaling complex scaffold activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001191878 RGD:621011	F		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0040752 MGI:MGI:3613677 PANTHER:PTN001191880 RGD:628772 RGD:69264	C		Seeded From UniProt	complete
colocalizes_with	GO:0008328	ionotropic glutamate receptor complex	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2671987 MGI:MGI:3613677 PANTHER:PTN001191878	C		Seeded From UniProt	complete
involved_in	GO:0007416	synapse assembly	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930016 MGI:MGI:2671987 PANTHER:PTN001191880	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:10433268^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9JLU4	F		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0729	F		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0009	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0284	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0297	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Saavedra, MV et al. (2008) Scaffolding proteins in highly purified rat olfactory cilia membranes. Neuroreport 19 1123-6 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Petralia, RS et al. (2005) Ontogeny of postsynaptic density proteins at glutamatergic synapses. Mol. Cell. Neurosci. 29 436-52 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 MacGillavry, HD et al. (2013) Nanoscale scaffolding domains within the postsynaptic density concentrate synaptic AMPA receptors. Neuron 78 615-22 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Verpelli, C et al. (2011) Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. J. Biol. Chem. 286 34839-50 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 Tu, JC et al. (1999) Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron 23 583-92 PubMed GONUTS page
↑ Wendholt, D et al. (2006) ProSAP-interacting protein 1 (ProSAPiP1), a novel protein of the postsynaptic density that links the spine-associated Rap-Gap (SPAR) to the scaffolding protein ProSAP2/Shank3. J. Biol. Chem. 281 13805-16 PubMed GONUTS page
↑ ^7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 Grabrucker, AM et al. (2011) Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation. EMBO J. 30 569-81 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Baron, MK et al. (2006) An architectural framework that may lie at the core of the postsynaptic density. Science 311 531-5 PubMed GONUTS page
↑ Böckers, TM et al. (2001) Synaptic scaffolding proteins in rat brain. Ankyrin repeats of the multidomain Shank protein family interact with the cytoskeletal protein alpha-fodrin. J. Biol. Chem. 276 40104-12 PubMed GONUTS page
↑ ^10.0 ^10.1 Qualmann, B et al. (2004) Linkage of the actin cytoskeleton to the postsynaptic density via direct interactions of Abp1 with the ProSAP/Shank family. J. Neurosci. 24 2481-95 PubMed GONUTS page
↑ Tobaben, S et al. (2000) The G protein-coupled receptor CL1 interacts directly with proteins of the Shank family. J. Biol. Chem. 275 36204-10 PubMed GONUTS page
↑ ^12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 ^12.11 ^12.12 ^12.13 ^12.14 ^12.15 ^12.16 ^12.17 ^12.18 ^12.19 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Naisbitt, S et al. (1999) Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin. Neuron 23 569-82 PubMed GONUTS page

[PMID:18596612-1] 1.0 ^1.1 ^1.2 Saavedra, MV et al. (2008) Scaffolding proteins in highly purified rat olfactory cilia membranes. Neuroreport 19 1123-6 PubMed GONUTS page

[PMID:15894489-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Petralia, RS et al. (2005) Ontogeny of postsynaptic density proteins at glutamatergic synapses. Mol. Cell. Neurosci. 29 436-52 PubMed GONUTS page

[PMID:23719161-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 MacGillavry, HD et al. (2013) Nanoscale scaffolding domains within the postsynaptic density concentrate synaptic AMPA receptors. Neuron 78 615-22 PubMed GONUTS page

[PMID:21795692-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Verpelli, C et al. (2011) Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. J. Biol. Chem. 286 34839-50 PubMed GONUTS page

[PMID:10433269-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 Tu, JC et al. (1999) Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron 23 583-92 PubMed GONUTS page

[PMID:16522626-6] Wendholt, D et al. (2006) ProSAP-interacting protein 1 (ProSAPiP1), a novel protein of the postsynaptic density that links the spine-associated Rap-Gap (SPAR) to the scaffolding protein ProSAP2/Shank3. J. Biol. Chem. 281 13805-16 PubMed GONUTS page

[PMID:21217644-7] 7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 Grabrucker, AM et al. (2011) Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation. EMBO J. 30 569-81 PubMed GONUTS page

[PMID:16439662-8] 8.0 ^8.1 ^8.2 ^8.3 Baron, MK et al. (2006) An architectural framework that may lie at the core of the postsynaptic density. Science 311 531-5 PubMed GONUTS page

[PMID:11509555-9] Böckers, TM et al. (2001) Synaptic scaffolding proteins in rat brain. Ankyrin repeats of the multidomain Shank protein family interact with the cytoskeletal protein alpha-fodrin. J. Biol. Chem. 276 40104-12 PubMed GONUTS page

[PMID:15014124-10] 10.0 ^10.1 Qualmann, B et al. (2004) Linkage of the actin cytoskeleton to the postsynaptic density via direct interactions of Abp1 with the ProSAP/Shank family. J. Neurosci. 24 2481-95 PubMed GONUTS page

[PMID:10958799-11] Tobaben, S et al. (2000) The G protein-coupled receptor CL1 interacts directly with proteins of the Shank family. J. Biol. Chem. 275 36204-10 PubMed GONUTS page

[PMID:21873635-12] 12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 ^12.11 ^12.12 ^12.13 ^12.14 ^12.15 ^12.16 ^12.17 ^12.18 ^12.19 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10433268-13] Naisbitt, S et al. (1999) Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin. Neuron 23 569-82 PubMed GONUTS page

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