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RAT:SECR

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Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Sct
Protein Name(s) Secretin
External Links
UniProt P11384
EMBL M31495
M64033
M63984
PIR A40886
RefSeq NP_073161.1
XP_006230580.1
UniGene Rn.9919
STRING 10116.ENSRNOP00000024094
Ensembl ENSRNOT00000024094
GeneID 24769
KEGG rno:24769
UCSC RGD:3643
CTD 6343
RGD 3643
eggNOG NOG329190
GeneTree ENSGT00390000002624
HOGENOM HOG000133017
HOVERGEN HBG017786
InParanoid P11384
KO K05263
OMA MPILQAW
OrthoDB EOG77DJ88
PhylomeDB P11384
TreeFam TF338215
Reactome REACT_235881
REACT_246814
NextBio 604336
PRO PR:P11384
Proteomes UP000002494
Genevestigator P11384
GO GO:0005576
GO:0021542
GO:0043524
GO:0097150
GO:0008542
InterPro IPR000532
IPR015675
PANTHER PTHR17378
Pfam PF00123
SMART SM00070
PROSITE PS00260

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:1903640

negative regulation of gastrin-induced gastric acid secretion

PMID:11123201[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090274

positive regulation of somatostatin secretion

PMID:11123201[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090187

positive regulation of pancreatic juice secretion

PMID:11123201[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048566

embryonic digestive tract development

PMID:1711228[2]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0047485

protein N-terminus binding

PMID:12403838[3]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:621342

F

Seeded From UniProt

complete

involved_in

GO:0043950

positive regulation of cAMP-mediated signaling

PMID:12403838[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007420

brain development

PMID:15276242[4]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:3047699[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

PMID:12403838[3]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:621342

F

Seeded From UniProt

complete

involved_in

GO:1903640

negative regulation of gastrin-induced gastric acid secretion

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001048642
RGD:3643

P

Seeded From UniProt

complete

involved_in

GO:0090274

positive regulation of somatostatin secretion

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001048642
RGD:3643

P

Seeded From UniProt

complete

involved_in

GO:0090187

positive regulation of pancreatic juice secretion

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001048642
RGD:3643

P

Seeded From UniProt

complete

involved_in

GO:0007420

brain development

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001048642
RGD:3643

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001048642
RGD:3643

C

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001048642
RGD:3643

F

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

enables

GO:0001664

G protein-coupled receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09683
ensembl:ENSP00000176195

F

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000532

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000532

C

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0372

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Solomon, TE et al. (2001) Different actions of secretin and Gly-extended secretin predict secretin receptor subtypes. Am. J. Physiol. Gastrointest. Liver Physiol. 280 G88-94 PubMed GONUTS page
  2. Kopin, AS et al. (1991) The secretin gene: evolutionary history, alternative splicing, and developmental regulation. Proc. Natl. Acad. Sci. U.S.A. 88 5335-9 PubMed GONUTS page
  3. 3.0 3.1 3.2 Dong, M et al. (2002) Interaction among four residues distributed through the secretin pharmacophore and a focused region of the secretin receptor amino terminus. Mol. Endocrinol. 16 2490-501 PubMed GONUTS page
  4. Tay, J et al. (2004) Age-related and regional differences in secretin and secretin receptor mRNA levels in the rat brain. Neurosci. Lett. 366 176-81 PubMed GONUTS page
  5. Murthy, SN & Ganiban, G () Effect of the secretin family of peptides on gastric emptying and small intestinal transit in rats. Peptides 9 583-8 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 6.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page