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RAT:PMP22

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Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Pmp22 (synonyms: Cd25, Pmp-22)
Protein Name(s) Peripheral myelin protein 22

PMP-22 Protein CD25 SR13 myelin protein Schwann cell membrane glycoprotein SAG

External Links
UniProt P25094
EMBL X62431
M69139
S55427
PIR A41144
RefSeq NP_058733.1
XP_006246646.1
XP_006246647.1
UniGene Rn.1476
ProteinModelPortal P25094
STRING 10116.ENSRNOP00000051201
ChEMBL CHEMBL2007624
Ensembl ENSRNOT00000041606
GeneID 24660
KEGG rno:24660
UCSC RGD:3359
CTD 5376
RGD 3359
eggNOG NOG43599
GeneTree ENSGT00510000046328
HOGENOM HOG000059542
HOVERGEN HBG001690
InParanoid P25094
OMA AIFTVRH
OrthoDB EOG7034KD
PhylomeDB P25094
TreeFam TF330414
NextBio 604014
PRO PR:P25094
Proteomes UP000002494
Genevestigator P25094
GO GO:0043218
GO:0016021
GO:0005886
GO:0005923
GO:0007050
GO:0030154
GO:0032288
GO:0042552
GO:0008285
GO:0010977
GO:0007422
InterPro IPR003936
IPR004031
IPR004032
Pfam PF00822
PRINTS PR01453
PR01458
PROSITE PS01221
PS01222

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0030308

negative regulation of cell growth

PMID:11519720[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Figure 3.A. The figure shows a significant inhibition of cell number in the over expressed PMP22 cell lines. However, the other two control (C6 & C6neo) cell lines had a much higher number of cells after a 96 hour incubation.

complete

GO:0008285

negative regulation of cell population proliferation

PMID:11519720[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Figure 3 A & B. Figure 3.A: The figure shows a significant inhibition of cell number in the over expressed PMP22 cell lines .However, the other two control (C6 & C6neo) cell lines had a much higher number of cells after a 96 hour incubation.

Figure 3.B: the figure shows that the PMP22 (which is highly expressed in clone #10 ) strongly inhibits the cell proliferation process when visualized by immunostaining with anti (BrdU) monoclonal antibody; compared to the C6neo (control) cell line after an 8 hour incubation.

complete

GO:0010977

negative regulation of neuron projection development

PMID:11519720[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Figure 5A.B. The figures show the difference in the growth cone of DRG neurons when co-cultured with PMP22 transfected cells compared to the control. The cell line #10 (which had a high expression of PMP22) and the cell line #26 (which had a moderate expression of PMP22) seemed to have a smaller amount of neurite cell growth compared to the control.

Note: a more specific GO term would be negative regulation of DRG neuron neurite outgrowth.

complete

GO:0007422

peripheral nervous system development

PMID:11519720[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Figure 5A.B. The figures show the difference in the growth cone of DRG neurons when co-cultured with PMP22 transfected cells compared to the control. The cell line #10 (which had a high expression of PMP22) and the cell line #26 (which had a moderate expression of PMP22) seemed to have a smaller amount of neurite cell growth compared to the control.

complete

GO:0007050

cell cycle arrest

PMID:11519720[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Figure 3.A. The figure shows a significant inhibition of cell number in the over expressed PMP22 cell lines. However, the other two control (C6 & C6neo) cell lines had a much higher number of cells after a 96 hour incubation.

complete

involved_in

GO:0010977

negative regulation of neuron projection development

PMID:11519720[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

PMID:11519720[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007422

peripheral nervous system development

PMID:11519720[1]

ECO:0000305

curator inference used in manual assertion

GO:0010977

P

Seeded From UniProt

complete

part_of

GO:0043218

compact myelin

PMID:1556154[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0042552

myelination

PMID:11456309[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042552

myelination

PMID:11456309[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

PMID:11456309[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:11717414[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

PMID:7720703[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005923

bicellular tight junction

PMID:11717414[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0042552

myelination

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000072455
RGD:3359

P

Seeded From UniProt

complete

involved_in

GO:0032288

myelin assembly

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97631
PANTHER:PTN000072455

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1098726
PANTHER:PTN002369799
RGD:2552
RGD:621482
UniProtKB:P54849
UniProtKB:P54851
UniProtKB:P54852
UniProtKB:Q01453
WB:WBGene00000523
WB:WBGene00021415

C

Seeded From UniProt

complete

involved_in

GO:0032060

bleb assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01453
ensembl:ENSP00000308937

P

Seeded From UniProt

complete

involved_in

GO:0008219

cell death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01453
ensembl:ENSP00000308937

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01453
ensembl:ENSP00000308937

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003936

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004031
InterPro:IPR004032

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0007050

cell cycle arrest

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0338

P

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Takeda, Y et al. (2001) Functional analysis for peripheral myelin protein PASII/PMP22: is it a member of claudin superfamily? Neurochem. Res. 26 599-607 PubMed GONUTS page
  2. ↑ Snipes, GJ et al. (1992) Characterization of a novel peripheral nervous system myelin protein (PMP-22/SR13). J. Cell Biol. 117 225-38 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Nobbio, L et al. (2001) PMP22 transgenic dorsal root ganglia cultures show myelin abnormalities similar to those of human CMT1A. Ann. Neurol. 50 47-55 PubMed GONUTS page
  4. ↑ 4.0 4.1 Notterpek, L et al. (2001) Peripheral myelin protein 22 is a constituent of intercellular junctions in epithelia. Proc. Natl. Acad. Sci. U.S.A. 98 14404-9 PubMed GONUTS page
  5. ↑ Zoidl, G et al. (1995) Retroviral-mediated gene transfer of the peripheral myelin protein PMP22 in Schwann cells: modulation of cell growth. EMBO J. 14 1122-8 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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