GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
RAT:PLPL9
Contents
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Pla2g6 (synonyms: Pnpla9) | |
| Protein Name(s) | 85/88 kDa calcium-independent phospholipase A2
CaI-PLA2 Group VI phospholipase A2 GVI PLA2 Intracellular membrane-associated calcium-independent phospholipase A2 beta iPLA2-beta Patatin-like phospholipase domain-containing protein 9 PNPLA9 | |
| External Links | ||
| UniProt | P97570 | |
| EMBL | U51898 AABR06052011 CH473950 CH473950 BC081916 | |
| RefSeq | NP_001005560.1 NP_001257725.1 XP_006242068.1 | |
| UniGene | Rn.44692 | |
| ProteinModelPortal | P97570 | |
| IntAct | P97570 | |
| STRING | 10116.ENSRNOP00000017104 | |
| ChEMBL | CHEMBL1075318 | |
| PhosphoSite | P97570 | |
| PaxDb | P97570 | |
| PRIDE | P97570 | |
| Ensembl | ENSRNOT00000016827 ENSRNOT00000017108 | |
| GeneID | 360426 | |
| KEGG | rno:360426 | |
| UCSC | RGD:628867 | |
| CTD | 8398 | |
| RGD | 628867 | |
| eggNOG | COG0666 | |
| GeneTree | ENSGT00530000063645 | |
| HOGENOM | HOG000013092 | |
| HOVERGEN | HBG053482 | |
| InParanoid | P97570 | |
| KO | K16343 | |
| OMA | EVYIYEH | |
| OrthoDB | EOG76T9QK | |
| PhylomeDB | P97570 | |
| TreeFam | TF319230 | |
| Reactome | REACT_194374 REACT_199127 REACT_199139 REACT_199147 | |
| NextBio | 35583980 | |
| PRO | PR:P97570 | |
| Proteomes | UP000002494 | |
| Genevestigator | P97570 | |
| GO | GO:0005829 GO:0005743 GO:0005739 GO:0043008 GO:0047499 GO:0032049 GO:0006935 GO:0016042 GO:0060135 GO:0007613 GO:0051967 GO:0090238 GO:2000304 GO:0007204 GO:0045921 GO:0035774 GO:0090037 GO:0001934 GO:0090200 GO:0045909 GO:1901339 GO:0034976 GO:0014832 | |
| Gene3D | 1.25.40.20 | |
| InterPro | IPR016035 IPR002110 IPR020683 IPR002641 | |
| Pfam | PF00023 PF12796 PF01734 | |
| PRINTS | PR01415 | |
| SMART | SM00248 | |
| SUPFAM | SSF48403 SSF52151 | |
| PROSITE | PS50297 PS50088 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:2000304 |
positive regulation of ceramide biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0090435 |
protein localization to nuclear envelope |
ECO:0000314 |
P |
Figure 4 shows that when PLA2-I was stained, fluorescence was only detected in the nucleus using confocal and phase contrast microscopy. There was no fluorescence and therefore no protein present anywhere else in the cell. |
complete | |||||
|
involved_in |
GO:1901339 |
regulation of store-operated calcium channel activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0097755 |
positive regulation of blood vessel diameter |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090238 |
positive regulation of arachidonic acid secretion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090238 |
positive regulation of arachidonic acid secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090200 |
positive regulation of release of cytochrome c from mitochondria |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090037 |
positive regulation of protein kinase C signaling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060135 |
maternal process involved in female pregnancy |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051967 |
negative regulation of synaptic transmission, glutamatergic |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0047499 |
calcium-independent phospholipase A2 activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045921 |
positive regulation of exocytosis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043008 |
ATP-dependent protein binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035774 |
positive regulation of insulin secretion involved in cellular response to glucose stimulus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034976 |
response to endoplasmic reticulum stress |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019901 |
protein kinase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
RGD:2262 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0014832 |
urinary bladder smooth muscle contraction |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007613 |
memory |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007204 |
positive regulation of cytosolic calcium ion concentration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001934 |
positive regulation of protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032049 |
cardiolipin biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O60733 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019731 |
antibacterial humoral response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O60733 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O60733 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005815 |
microtubule organizing center |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O60733 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O60733 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017171 |
serine hydrolase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97819 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004623 |
phospholipase A2 activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0102567 |
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0102568 |
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005743 |
mitochondrial inner membrane |
Reactome:R-RNO-1482836 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004623 |
phospholipase A2 activity |
Reactome:R-RNO-1482836 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005516 |
calmodulin binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006935 |
chemotaxis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016042 |
lipid catabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Lei, X et al. (2008) Calcium-independent phospholipase A2 (iPLA2 beta)-mediated ceramide generation plays a key role in the cross-talk between the endoplasmic reticulum (ER) and mitochondria during ER stress-induced insulin-secreting cell apoptosis. J. Biol. Chem. 283 34819-32 PubMed GONUTS page
- ↑ Fayard, JM et al. (1998) Nuclear location of PLA2-I in proliferative cells. J. Cell. Sci. 111 ( Pt 7) 985-94 PubMed GONUTS page
- ↑ Smani, T et al. (2003) Ca2+-independent phospholipase A2 is a novel determinant of store-operated Ca2+ entry. J. Biol. Chem. 278 11909-15 PubMed GONUTS page
- ↑ Seegers, HC et al. (2002) Calcium-independent phospholipase A(2)-derived arachidonic acid is essential for endothelium-dependent relaxation by acetylcholine. J. Pharmacol. Exp. Ther. 302 918-23 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Song, H et al. (2010) Effects of endoplasmic reticulum stress on group VIA phospholipase A2 in beta cells include tyrosine phosphorylation and increased association with calnexin. J. Biol. Chem. 285 33843-57 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Wang, Z et al. (2005) Group VIA phospholipase A2 forms a signaling complex with the calcium/calmodulin-dependent protein kinase IIbeta expressed in pancreatic islet beta-cells. J. Biol. Chem. 280 6840-9 PubMed GONUTS page
- ↑ Xie, Z et al. (2011) Identification of a cAMP-response element in the regulator of G-protein signaling-2 (RGS2) promoter as a key cis-regulatory element for RGS2 transcriptional regulation by angiotensin II in cultured vascular smooth muscles. J. Biol. Chem. 286 44646-58 PubMed GONUTS page
- ↑ Brant, K et al. (2006) Gestation age-related increase in 50-kDa rat uterine calcium-independent phospholipase A2 expression influences uterine sensitivity to polychlorinated biphenyl stimulation. Biol. Reprod. 74 874-80 PubMed GONUTS page
- ↑ St-Gelais, F et al. (2004) Postsynaptic injection of calcium-independent phospholipase A2 inhibitors selectively increases AMPA receptor-mediated synaptic transmission. Hippocampus 14 319-25 PubMed GONUTS page
- ↑ 10.0 10.1 Ma, Z et al. (1997) Pancreatic islets express a Ca2+-independent phospholipase A2 enzyme that contains a repeated structural motif homologous to the integral membrane protein binding domain of ankyrin. J. Biol. Chem. 272 11118-27 PubMed GONUTS page
- ↑ Bloch-Shilderman, E et al. (2002) Pardaxin stimulation of phospholipases A2 and their involvement in exocytosis in PC-12 cells. J. Pharmacol. Exp. Ther. 301 953-62 PubMed GONUTS page
- ↑ Ma, Z et al. (2001) Studies of insulin secretory responses and of arachidonic acid incorporation into phospholipids of stably transfected insulinoma cells that overexpress group VIA phospholipase A2 (iPLA2beta ) indicate a signaling rather than a housekeeping role for iPLA2beta. J. Biol. Chem. 276 13198-208 PubMed GONUTS page
- ↑ Kubota, Y et al. (2003) Possible involvement of Ca2+-independent phospholipase A2 in protease-activated receptor-2-mediated contraction of rat urinary bladder. Naunyn Schmiedebergs Arch. Pharmacol. 367 588-91 PubMed GONUTS page
- ↑ Schaeffer, EL & Gattaz, WF (2005) Inhibition of calcium-independent phospholipase A2 activity in rat hippocampus impairs acquisition of short- and long-term memory. Psychopharmacology (Berl.) 181 392-400 PubMed GONUTS page
- ↑ Strokin, M et al. (2011) Proinflammatory treatment of astrocytes with lipopolysaccharide results in augmented Ca2+ signaling through increased expression of via phospholipase A2 (iPLA2). Am. J. Physiol., Cell Physiol. 300 C542-9 PubMed GONUTS page
c
g
m
p
- GO:0102568 ! phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
- GO:0102567 ! phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
- GO:0004623 ! phospholipase A2 activity
- GO:2000304 ! positive regulation of ceramide biosynthetic process
- GO:0045921 ! positive regulation of exocytosis
- GO:0035774 ! positive regulation of insulin secretion involved in cellular response to glucose stimulus
- GO:0001934 ! positive regulation of protein phosphorylation
- GO:0007204 ! positive regulation of cytosolic calcium ion concentration
- GO:0090238 ! positive regulation of arachidonate secretion
- GO:0090200 ! positive regulation of release of cytochrome c from mitochondria
- GO:0090037 ! positive regulation of protein kinase C signaling
- GO:0019901 ! protein kinase binding
- GO:0090435 ! protein localization to nuclear envelope
r
