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RAT:OSTP

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Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Spp1 (synonyms: 2b7, Spp-1)
Protein Name(s) Osteopontin

Bone sialoprotein 1 Secreted phosphoprotein 1 SPP-1

External Links
UniProt P08721
EMBL M99252
M14656
BC078874
PIR A25917
JC5811
RefSeq NP_037013.2
XP_008768218.1
UniGene Rn.8871
BioGrid 247392
IntAct P08721
MINT MINT-8283233
STRING 10116.ENSRNOP00000062358
PhosphoSite P08721
PaxDb P08721
PRIDE P08721
Ensembl ENSRNOT00000067875
ENSRNOT00000075989
GeneID 25353
KEGG rno:25353
CTD 6696
RGD 3752
eggNOG NOG73598
GeneTree ENSGT00390000002509
HOGENOM HOG000059656
HOVERGEN HBG001731
InParanoid P08721
KO K06250
OMA VICFCLL
OrthoDB EOG7R832D
PhylomeDB P08721
Reactome REACT_199178
REACT_212371
REACT_252097
NextBio 606305
PRO PR:P08721
Proteomes UP000002494
Genevestigator P08721
GO GO:0045177
GO:0042995
GO:0005615
GO:0070062
GO:0031988
GO:0048471
GO:0050840
GO:0031214
GO:0007155
GO:0030154
GO:0006954
GO:0048685
GO:0030593
GO:0001649
GO:0045780
GO:0010811
GO:0010033
GO:0048545
GO:0033280
InterPro IPR002038
IPR019841
PANTHER PTHR10607
Pfam PF00865
PRINTS PR00216
SMART SM00017
PROSITE PS00884

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0048685

negative regulation of collateral sprouting of intact axon in response to injury

PMID:15625076[1]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048545

response to steroid hormone

PMID:11250650[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

PMID:12162503[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045780

positive regulation of bone resorption

PMID:11792563[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0042995

cell projection

PMID:12162503[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031982

vesicle

PMID:18758911[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

PMID:16618210[6]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010033

response to organic substance

PMID:16414014[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

PMID:3024151[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

PMID:11792563[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

PMID:16679731[9]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:18758911[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0001649

osteoblast differentiation

PMID:15598896[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0050840

extracellular matrix binding

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98389
PANTHER:PTN000064588

F

Seeded From UniProt

complete

involved_in

GO:0045780

positive regulation of bone resorption

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000064588
RGD:3752

P

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000064588
RGD:3752

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000064588
RGD:3752
UniProtKB:P10451

C

Seeded From UniProt

complete

involved_in

GO:0001649

osteoblast differentiation

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000064588
RGD:3752

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

involved_in

GO:2000866

positive regulation of estradiol secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10451
ensembl:ENSP00000378517

P

Seeded From UniProt

complete

involved_in

GO:0071394

cellular response to testosterone stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10451
ensembl:ENSP00000378517

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10451
ensembl:ENSP00000378517

P

Seeded From UniProt

complete

involved_in

GO:0033280

response to vitamin D

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10451
ensembl:ENSP00000378517

P

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10451
ensembl:ENSP00000378517

P

Seeded From UniProt

complete

involved_in

GO:0006710

androgen catabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10451
ensembl:ENSP00000378517

P

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10451
ensembl:ENSP00000378517

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10451
ensembl:ENSP00000378517

C

Seeded From UniProt

complete

enables

GO:0005178

integrin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10451
ensembl:ENSP00000378517

F

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A0A024RDE2
ensembl:ENSP00000378517

C

Seeded From UniProt

complete

involved_in

GO:0001503

ossification

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002038
InterPro:IPR019841

P

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002038
InterPro:IPR019841

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:12162503[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0130

P

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

C

Seeded From UniProt

complete

involved_in

GO:0031214

biomineral tissue development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0091

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Küry, P et al. (2005) Osteopontin, a macrophage-derived matricellular glycoprotein, inhibits axon outgrowth. FASEB J. 19 398-400 PubMed GONUTS page
  2. ↑ Ehrchen, J et al. (2001) Expression and regulation of osteopontin and connective tissue growth factor transcripts in rat anterior pituitary. J. Endocrinol. 169 87-96 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Suzuki, K et al. (2002) Colocalization of intracellular osteopontin with CD44 is associated with migration, cell fusion, and resorption in osteoclasts. J. Bone Miner. Res. 17 1486-97 PubMed GONUTS page
  4. ↑ 4.0 4.1 Razzouk, S et al. (2002) Osteopontin posttranslational modifications, possibly phosphorylation, are required for in vitro bone resorption but not osteoclast adhesion. Bone 30 40-7 PubMed GONUTS page
  5. ↑ 5.0 5.1 Nahar, NN et al. (2008) Matrix vesicles are carriers of bone morphogenetic proteins (BMPs), vascular endothelial growth factor (VEGF), and noncollagenous matrix proteins. J. Bone Miner. Metab. 26 514-9 PubMed GONUTS page
  6. ↑ Pereira, RO et al. () Osteopontin expression in coculture of differentiating rat fetal skeletal fibroblasts and myoblasts. In Vitro Cell. Dev. Biol. Anim. 42 4-7 PubMed GONUTS page
  7. ↑ Wejheden, C et al. (2006) Osteopontin: a rapid and sensitive response to dioxin exposure in the osteoblastic cell line UMR-106. Biochem. Biophys. Res. Commun. 341 116-20 PubMed GONUTS page
  8. ↑ Oldberg, A et al. (1986) Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence. Proc. Natl. Acad. Sci. U.S.A. 83 8819-23 PubMed GONUTS page
  9. ↑ Shin, T et al. (2006) Increased expression of osteopontin in the heart tissue of Lewis rats with experimental autoimmune myocarditis. J. Vet. Med. Sci. 68 379-82 PubMed GONUTS page
  10. ↑ Kojima, H et al. (2004) In vitro and in vivo effects of the overexpression of osteopontin on osteoblast differentiation using a recombinant adenoviral vector. J. Biochem. 136 377-86 PubMed GONUTS page
  11. ↑ 11.0 11.1 11.2 11.3 11.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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