RAT:NRAM2

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Slc11a2 (synonyms: Dct1, Dmt1, Nramp2)
Protein Name(s)	Natural resistance-associated macrophage protein 2 NRAMP 2 Divalent cation transporter 1 Divalent metal transporter 1 DMT-1 Solute carrier family 11 member 2
External Links
UniProt	O54902
EMBL	AF008439 AF029757
RefSeq	NP_037305.2
UniGene	Rn.11418
ProteinModelPortal	O54902
BioGrid	247744
STRING	10116.ENSRNOP00000026494
TCDB	2.A.55.2.2
Ensembl	ENSRNOT00000026531
GeneID	25715
KEGG	rno:25715
UCSC	RGD:3684
CTD	4891
RGD	3684
eggNOG	COG1914
GeneTree	ENSGT00390000006526
HOGENOM	HOG000152203
HOVERGEN	HBG052665
InParanoid	O54902
KO	K12347
OMA	AFHFNGH
OrthoDB	EOG77127K
PhylomeDB	O54902
Reactome	REACT_248611 REACT_254464
NextBio	607793
PRO	PR:O54902
Proteomes	UP000002494
Genevestigator	O54902
GO	GO:0045177 GO:0016324 GO:0045178 GO:0005903 GO:0009986 GO:0005737 GO:0031410 GO:0005769 GO:0016021 GO:0005887 GO:0031902 GO:0005765 GO:0005634 GO:0070826 GO:0048471 GO:0055037 GO:0005802 GO:0046870 GO:0015086 GO:0050897 GO:0015087 GO:0005507 GO:0005375 GO:0015093 GO:0015078 GO:0005506 GO:0005381 GO:0015094 GO:0030145 GO:0005384 GO:0016151 GO:0015099 GO:0015295 GO:0015100 GO:0008270 GO:0005385 GO:0006919 GO:0006878 GO:0071456 GO:0071281 GO:0034599 GO:0071356 GO:1902861 GO:0035434 GO:0048813 GO:0003032 GO:0048821 GO:0070627 GO:0015684 GO:0006783 GO:0034755 GO:0007611 GO:0060586 GO:0046686 GO:0001666 GO:0010039 GO:0010288 GO:0010042 GO:0000041
HAMAP	MF_00221
InterPro	IPR001046
PANTHER	PTHR11706
Pfam	PF01566
PRINTS	PR00447
TIGRFAMs	TIGR01197

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0006826	iron ion transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49281-2	P	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49281	C	Seeded From UniProt	complete
enables	GO:0015093	ferrous iron transmembrane transporter activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49281	F	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49281	C	Seeded From UniProt	complete
involved_in	GO:0098705	copper ion import across plasma membrane	PMID:22442359^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	PMID:21325818^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	PMID:16221503^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071281	cellular response to iron ion	PMID:17663481^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0050897	cobalt ion binding	PMID:9242408^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0046870	cadmium ion binding	PMID:9242408^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0046686	response to cadmium ion	PMID:19083094^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	PMID:18420243^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0031902	late endosome membrane	PMID:16449358^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0030145	manganese ion binding	PMID:9242408^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0016151	nickel cation binding	PMID:9242408^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:9242408^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0015099	nickel cation transmembrane transporter activity	PMID:9242408^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0015094	lead ion transmembrane transporter activity	PMID:9242408^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0015093	ferrous iron transmembrane transporter activity	PMID:16091957^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0015087	cobalt ion transmembrane transporter activity	PMID:9242408^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0015086	cadmium ion transmembrane transporter activity	PMID:9242408^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0010288	response to lead ion	PMID:19083094^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010042	response to manganese ion	PMID:18849539^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010042	response to manganese ion	PMID:17060373^[11]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010039	response to iron ion	PMID:12876064^[12]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:9242408^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006826	iron ion transport	PMID:16091957^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	PMID:16449358^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11891802^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	PMID:9242408^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005506	iron ion binding	PMID:9242408^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005384	manganese ion transmembrane transporter activity	PMID:9242408^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005381	iron ion transmembrane transporter activity	PMID:9242408^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005375	copper ion transmembrane transporter activity	PMID:9242408^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:21325818^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000041	transition metal ion transport	PMID:9242408^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:1903561	extracellular vesicle	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1345279 PANTHER:PTN000194457 UniProtKB:P49281	C	Seeded From UniProt	complete
involved_in	GO:0060586	multicellular organismal iron ion homeostasis	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1345279 PANTHER:PTN000194457 UniProtKB:P49281	P	Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1345279 PANTHER:PTN000194457 UniProtKB:P49281	C	Seeded From UniProt	complete
enables	GO:0050897	cobalt ion binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000194457 RGD:3684	F	Seeded From UniProt	complete
enables	GO:0046870	cadmium ion binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000194457 RGD:3684 UniProtKB:P49281	F	Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000194457 RGD:3684 UniProtKB:P49281	C	Seeded From UniProt	complete
part_of	GO:0031902	late endosome membrane	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000194457 RGD:3684 UniProtKB:P49281	C	Seeded From UniProt	complete
enables	GO:0030145	manganese ion binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000194457 RGD:3684	F	Seeded From UniProt	complete
enables	GO:0016151	nickel cation binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000194457 RGD:3684	F	Seeded From UniProt	complete
enables	GO:0015295	solute:proton symporter activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000194457 UniProtKB:P49281	F	Seeded From UniProt	complete
enables	GO:0015099	nickel cation transmembrane transporter activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000194457 RGD:3684 UniProtKB:P49281	F	Seeded From UniProt	complete
enables	GO:0015094	lead ion transmembrane transporter activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000194457 RGD:3684 UniProtKB:P49281	F	Seeded From UniProt	complete
enables	GO:0015093	ferrous iron transmembrane transporter activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1345279 PANTHER:PTN000194457 RGD:3684 UniProtKB:P49281	F	Seeded From UniProt	complete
enables	GO:0015087	cobalt ion transmembrane transporter activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1345279 PANTHER:PTN000194457 RGD:3684 UniProtKB:P49281	F	Seeded From UniProt	complete
enables	GO:0015086	cadmium ion transmembrane transporter activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG14157 PANTHER:PTN000194431 RGD:3684 TAIR:locus:2025677 TAIR:locus:2200437 UniProtKB:P49281 UniProtKB:P51027	F	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1345279 PANTHER:PTN000194457 UniProtKB:P49281	C	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000194457 RGD:3684	F	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1345279 PANTHER:PTN000194457 UniProtKB:P49281	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1345279 PANTHER:PTN000194437 UniProtKB:P49279 UniProtKB:P49281 UniProtKB:P51027	C	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1345279 PANTHER:PTN000194457 UniProtKB:P49281	C	Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000194457 RGD:3684 UniProtKB:P49281	C	Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000194457 RGD:3684	F	Seeded From UniProt	complete
enables	GO:0005506	iron ion binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000194457 RGD:3684	F	Seeded From UniProt	complete
enables	GO:0005384	manganese ion transmembrane transporter activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG14157 FB:FBgn0011672 MGI:MGI:1345275 PANTHER:PTN000194431 RGD:3684 TAIR:locus:2025677 TAIR:locus:2036751 UniProtKB:P49281 UniProtKB:Q6ZG85	F	Seeded From UniProt	complete
enables	GO:0005384	manganese ion transmembrane transporter activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG14157 FB:FBgn0011672 MGI:MGI:1345275 PANTHER:PTN000194431 RGD:3684 TAIR:locus:2025677 TAIR:locus:2036751 UniProtKB:P49281	F	Seeded From UniProt	complete
enables	GO:0005381	iron ion transmembrane transporter activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1345279 PANTHER:PTN000194457 RGD:3684	F	Seeded From UniProt	complete
enables	GO:0005375	copper ion transmembrane transporter activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000194457 RGD:3684 UniProtKB:P49281	F	Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000194457 RGD:3684 UniProtKB:P49281	P	Seeded From UniProt	complete
involved_in	GO:0006824	cobalt ion transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015087	P	Seeded From UniProt	complete
involved_in	GO:0006824	cobalt ion transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015087	P	Seeded From UniProt	complete
involved_in	GO:0015692	lead ion transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015094	P	Seeded From UniProt	complete
involved_in	GO:0015692	lead ion transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015094	P	Seeded From UniProt	complete
involved_in	GO:0034755	iron ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015093	P	Seeded From UniProt	complete
involved_in	GO:0034755	iron ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005381	P	Seeded From UniProt	complete
involved_in	GO:0034755	iron ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015093	P	Seeded From UniProt	complete
involved_in	GO:0034755	iron ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005381	P	Seeded From UniProt	complete
involved_in	GO:0034755	iron ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015093	P	Seeded From UniProt	complete
involved_in	GO:0035444	nickel cation transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015099	P	Seeded From UniProt	complete
involved_in	GO:0035444	nickel cation transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015099	P	Seeded From UniProt	complete
involved_in	GO:0070574	cadmium ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015086	P	Seeded From UniProt	complete
involved_in	GO:0070574	cadmium ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015086	P	Seeded From UniProt	complete
involved_in	GO:0071421	manganese ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005384	P	Seeded From UniProt	complete
involved_in	GO:0071421	manganese ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005384	P	Seeded From UniProt	complete
involved_in	GO:0071421	manganese ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005384	P	Seeded From UniProt	complete
involved_in	GO:0072511	divalent inorganic cation transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015093	P	Seeded From UniProt	complete
involved_in	GO:0072511	divalent inorganic cation transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015093	P	Seeded From UniProt	complete
involved_in	GO:0072511	divalent inorganic cation transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015093	P	Seeded From UniProt	complete
involved_in	GO:1902600	proton transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015295	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001046	C	Seeded From UniProt	complete
involved_in	GO:0030001	metal ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001046	P	Seeded From UniProt	complete
enables	GO:0046873	metal ion transmembrane transporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001046	F	Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1000 UniProtKB-SubCell:SL-0172	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
involved_in	GO:0055072	iron ion homeostasis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0410	P	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0100	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Monnot, AD et al. (2012) Mechanism of copper transport at the blood-cerebrospinal fluid barrier: influence of iron deficiency in an in vitro model. Exp. Biol. Med. (Maywood) 237 327-33 PubMed GONUTS page
↑ ^2.0 ^2.1 Yang, L et al. (2011) Tanshinone IIA prevented brain iron dyshomeostasis in cerebral ischemic rats. Cell. Physiol. Biochem. 27 23-30 PubMed GONUTS page
↑ Dzikaite, V et al. (2006) Regulatory effects of tumor necrosis factor-alpha and interleukin-6 on HAMP expression in iron loaded rat hepatocytes. J. Hepatol. 44 544-51 PubMed GONUTS page
↑ Song, N et al. (2007) Divalent metal transporter 1 up-regulation is involved in the 6-hydroxydopamine-induced ferrous iron influx. J. Neurosci. Res. 85 3118-26 PubMed GONUTS page
↑ ^5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 ^5.12 ^5.13 ^5.14 ^5.15 Gunshin, H et al. (1997) Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388 482-8 PubMed GONUTS page
↑ ^6.0 ^6.1 Gu, C et al. (2009) Lead and cadmium synergistically enhance the expression of divalent metal transporter 1 protein in central nervous system of developing rats. Neurochem. Res. 34 1150-6 PubMed GONUTS page
↑ Wang, X et al. (2008) Intracellular localization and subsequent redistribution of metal transporters in a rat choroid plexus model following exposure to manganese or iron. Toxicol. Appl. Pharmacol. 230 167-74 PubMed GONUTS page
↑ ^8.0 ^8.1 Abouhamed, M et al. (2006) Divalent metal transporter 1 in the kidney proximal tubule is expressed in late endosomes/lysosomal membranes: implications for renal handling of protein-metal complexes. Am. J. Physiol. Renal Physiol. 290 F1525-33 PubMed GONUTS page
↑ ^9.0 ^9.1 Mackenzie, B et al. (2006) Divalent metal-ion transporter DMT1 mediates both H+ -coupled Fe2+ transport and uncoupled fluxes. Pflugers Arch. 451 544-58 PubMed GONUTS page
↑ Wang, X et al. (2008) Efflux of iron from the cerebrospinal fluid to the blood at the blood-CSF barrier: effect of manganese exposure. Exp. Biol. Med. (Maywood) 233 1561-71 PubMed GONUTS page
↑ Garcia, SJ et al. (2007) Iron deficient and manganese supplemented diets alter metals and transporters in the developing rat brain. Toxicol. Sci. 95 205-14 PubMed GONUTS page
↑ Wareing, M et al. (2003) Altered dietary iron intake is a strong modulator of renal DMT1 expression. Am. J. Physiol. Renal Physiol. 285 F1050-9 PubMed GONUTS page
↑ Simovich, MJ et al. (2002) Cellular location of proteins related to iron absorption and transport. Am. J. Hematol. 69 164-70 PubMed GONUTS page
↑ ^14.00 ^14.01 ^14.02 ^14.03 ^14.04 ^14.05 ^14.06 ^14.07 ^14.08 ^14.09 ^14.10 ^14.11 ^14.12 ^14.13 ^14.14 ^14.15 ^14.16 ^14.17 ^14.18 ^14.19 ^14.20 ^14.21 ^14.22 ^14.23 ^14.24 ^14.25 ^14.26 ^14.27 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22442359-1] Monnot, AD et al. (2012) Mechanism of copper transport at the blood-cerebrospinal fluid barrier: influence of iron deficiency in an in vitro model. Exp. Biol. Med. (Maywood) 237 327-33 PubMed GONUTS page

[PMID:21325818-2] 2.0 ^2.1 Yang, L et al. (2011) Tanshinone IIA prevented brain iron dyshomeostasis in cerebral ischemic rats. Cell. Physiol. Biochem. 27 23-30 PubMed GONUTS page

[PMID:16221503-3] Dzikaite, V et al. (2006) Regulatory effects of tumor necrosis factor-alpha and interleukin-6 on HAMP expression in iron loaded rat hepatocytes. J. Hepatol. 44 544-51 PubMed GONUTS page

[PMID:17663481-4] Song, N et al. (2007) Divalent metal transporter 1 up-regulation is involved in the 6-hydroxydopamine-induced ferrous iron influx. J. Neurosci. Res. 85 3118-26 PubMed GONUTS page

[PMID:9242408-5] 5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 ^5.12 ^5.13 ^5.14 ^5.15 Gunshin, H et al. (1997) Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388 482-8 PubMed GONUTS page

[PMID:19083094-6] 6.0 ^6.1 Gu, C et al. (2009) Lead and cadmium synergistically enhance the expression of divalent metal transporter 1 protein in central nervous system of developing rats. Neurochem. Res. 34 1150-6 PubMed GONUTS page

[PMID:18420243-7] Wang, X et al. (2008) Intracellular localization and subsequent redistribution of metal transporters in a rat choroid plexus model following exposure to manganese or iron. Toxicol. Appl. Pharmacol. 230 167-74 PubMed GONUTS page

[PMID:16449358-8] 8.0 ^8.1 Abouhamed, M et al. (2006) Divalent metal transporter 1 in the kidney proximal tubule is expressed in late endosomes/lysosomal membranes: implications for renal handling of protein-metal complexes. Am. J. Physiol. Renal Physiol. 290 F1525-33 PubMed GONUTS page

[PMID:16091957-9] 9.0 ^9.1 Mackenzie, B et al. (2006) Divalent metal-ion transporter DMT1 mediates both H+ -coupled Fe2+ transport and uncoupled fluxes. Pflugers Arch. 451 544-58 PubMed GONUTS page

[PMID:18849539-10] Wang, X et al. (2008) Efflux of iron from the cerebrospinal fluid to the blood at the blood-CSF barrier: effect of manganese exposure. Exp. Biol. Med. (Maywood) 233 1561-71 PubMed GONUTS page

[PMID:17060373-11] Garcia, SJ et al. (2007) Iron deficient and manganese supplemented diets alter metals and transporters in the developing rat brain. Toxicol. Sci. 95 205-14 PubMed GONUTS page

[PMID:12876064-12] Wareing, M et al. (2003) Altered dietary iron intake is a strong modulator of renal DMT1 expression. Am. J. Physiol. Renal Physiol. 285 F1050-9 PubMed GONUTS page

[PMID:11891802-13] Simovich, MJ et al. (2002) Cellular location of proteins related to iron absorption and transport. Am. J. Hematol. 69 164-70 PubMed GONUTS page

[PMID:21873635-14] 14.00 ^14.01 ^14.02 ^14.03 ^14.04 ^14.05 ^14.06 ^14.07 ^14.08 ^14.09 ^14.10 ^14.11 ^14.12 ^14.13 ^14.14 ^14.15 ^14.16 ^14.17 ^14.18 ^14.19 ^14.20 ^14.21 ^14.22 ^14.23 ^14.24 ^14.25 ^14.26 ^14.27 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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