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RAT:NPY
Contents
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Npy | |
| Protein Name(s) | Pro-neuropeptide Y
Neuropeptide Y Neuropeptide tyrosine NPY C-flanking peptide of NPY CPON | |
| External Links | ||
| UniProt | P07808 | |
| EMBL | M15880 M15793 M15792 M20373 AF392056 AF392057 AF392058 AF392059 AF392060 AF392061 | |
| PIR | A27651 | |
| RefSeq | NP_036746.1 XP_003749793.1 | |
| UniGene | Rn.9714 | |
| ProteinModelPortal | P07808 | |
| SMR | P07808 | |
| STRING | 10116.ENSRNOP00000013146 | |
| BindingDB | P07808 | |
| PRIDE | P07808 | |
| Ensembl | ENSRNOT00000013145 | |
| GeneID | 100912228 24604 | |
| KEGG | rno:100912228 rno:24604 | |
| UCSC | RGD:3197 | |
| CTD | 4852 | |
| RGD | 3197 | |
| eggNOG | NOG45909 | |
| GeneTree | ENSGT00390000010775 | |
| HOGENOM | HOG000252942 | |
| HOVERGEN | HBG006485 | |
| InParanoid | P07808 | |
| KO | K05232 | |
| OMA | FEDPSMW | |
| OrthoDB | EOG7WDN4S | |
| PhylomeDB | P07808 | |
| TreeFam | TF332778 | |
| Reactome | REACT_233455 REACT_250028 | |
| NextBio | 603820 | |
| PMAP-CutDB | P07808 | |
| PRO | PR:P07808 | |
| Proteomes | UP000002494 | |
| ExpressionAtlas | P07808 | |
| Genevestigator | P07808 | |
| GO | GO:0005615 GO:0001664 GO:0004983 GO:0031841 GO:0008343 GO:0007631 GO:0045776 GO:0007218 GO:0032100 GO:0008217 GO:0050909 GO:0007268 | |
| InterPro | IPR001955 IPR020392 | |
| PANTHER | PTHR10533 | |
| Pfam | PF00159 | |
| PRINTS | PR00278 | |
| ProDom | PD001267 | |
| SMART | SM00309 | |
| PROSITE | PS00265 PS50276 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0032100 |
positive regulation of appetite |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008343 |
adult feeding behavior |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1904407 |
positive regulation of nitric oxide metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1904000 |
positive regulation of eating behavior |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1901215 |
negative regulation of neuron death |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050909 |
sensory perception of taste |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048572 |
short-day photoperiodism |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045964 |
positive regulation of dopamine metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045776 |
negative regulation of blood pressure |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043204 |
perikaryon |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043195 |
terminal bouton |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043005 |
neuron projection |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042117 |
monocyte activation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032903 |
regulation of nerve growth factor production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031841 |
neuropeptide Y receptor binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010811 |
positive regulation of cell-substrate adhesion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007568 |
aging |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007268 |
chemical synaptic transmission |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007218 |
neuropeptide signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007218 |
neuropeptide signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002865 |
negative regulation of acute inflammatory response to antigenic stimulus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031841 |
neuropeptide Y receptor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000056515 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007218 |
neuropeptide signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000056513 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:97753 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005184 |
neuropeptide hormone activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:99924 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0001664 |
G protein-coupled receptor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:97374 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005179 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005184 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005179 |
hormone activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007218 |
neuropeptide signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Kristensen, P et al. (1998) Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature 393 72-6 PubMed GONUTS page
- ↑ 2.0 2.1 Dimitrijević, M et al. (2008) The anti-inflammatory effect of neuropeptide Y (NPY) in rats is dependent on dipeptidyl peptidase 4 (DP4) activity and age. Peptides 29 2179-87 PubMed GONUTS page
- ↑ Currie, PJ et al. (2011) Urocortin I inhibits the effects of ghrelin and neuropeptide Y on feeding and energy substrate utilization. Brain Res. 1385 127-34 PubMed GONUTS page
- ↑ 4.0 4.1 Croce, N et al. (2012) Neuropeptide Y protects rat cortical neurons against β-amyloid toxicity and re-establishes synthesis and release of nerve growth factor. ACS Chem Neurosci 3 312-8 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Igura, K et al. (2011) Neuropeptide y and neuropeptide y y5 receptor interaction restores impaired growth potential of aging bone marrow stromal cells. Rejuvenation Res 14 393-403 PubMed GONUTS page
- ↑ 6.0 6.1 Zhao, FL et al. (2005) Expression, physiological action, and coexpression patterns of neuropeptide Y in rat taste-bud cells. Proc. Natl. Acad. Sci. U.S.A. 102 11100-5 PubMed GONUTS page
- ↑ Ross, AW et al. (2009) Divergent regulation of hypothalamic neuropeptide Y and agouti-related protein by photoperiod in F344 rats with differential food intake and growth. J. Neuroendocrinol. 21 610-9 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Alvaro, AR et al. (2007) NPY in rat retina is present in neurons, in endothelial cells and also in microglial and Müller cells. Neurochem. Int. 50 757-63 PubMed GONUTS page
- ↑ Sørensen, G et al. (2009) Neuropeptide Y infusion into the shell region of the rat nucleus accumbens increases extracellular levels of dopamine. Neuroreport 20 1023-6 PubMed GONUTS page
- ↑ Michalkiewicz, M et al. (2005) Central neuropeptide Y signaling ameliorates N(omega)-nitro-L-arginine methyl ester hypertension in the rat through a Y1 receptor mechanism. Hypertension 45 780-5 PubMed GONUTS page
- ↑ 11.0 11.1 Polgár, E et al. (2011) Quantitative study of NPY-expressing GABAergic neurons and axons in rat spinal dorsal horn. J. Comp. Neurol. 519 1007-23 PubMed GONUTS page
- ↑ 12.0 12.1 Nave, H et al. (2004) Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y2 receptor activation. J. Neuroimmunol. 155 1-12 PubMed GONUTS page
- ↑ Fekete, C et al. (2002) Neuropeptide Y1 and Y5 receptors mediate the effects of neuropeptide Y on the hypothalamic-pituitary-thyroid axis. Endocrinology 143 4513-9 PubMed GONUTS page
- ↑ Bacci, A et al. (2002) Differential modulation of synaptic transmission by neuropeptide Y in rat neocortical neurons. Proc. Natl. Acad. Sci. U.S.A. 99 17125-30 PubMed GONUTS page
- ↑ Wirth, MJ et al. (2005) Transcellular induction of neuropeptide Y expression by NT4 and BDNF. Proc. Natl. Acad. Sci. U.S.A. 102 3064-9 PubMed GONUTS page
- ↑ 16.0 16.1 16.2 16.3 16.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
e
n
p
- GO:0043204 ! perikaryon
- GO:0048471 ! perinuclear region of cytoplasm
- GO:0032100 ! positive regulation of appetite
- GO:0008284 ! positive regulation of cell population proliferation
- GO:0010811 ! positive regulation of cell-substrate adhesion
- GO:0045964 ! positive regulation of dopamine metabolic process
- GO:0070374 ! positive regulation of ERK1 and ERK2 cascade
- GO:1904000 ! positive regulation of eating behavior
- GO:1904407 ! positive regulation of nitric oxide metabolic process
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