RAT:MRP1

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Abcc1 (synonyms: Mrp1)
Protein Name(s)	Multidrug resistance-associated protein 1 ATP-binding cassette sub-family C member 1 Leukotriene C(4) transporter LTC4 transporter
External Links
UniProt	Q8CG09
EMBL	AY170916 AF487549 AY174892 AJ277881 X96394
RefSeq	NP_071617.2
UniGene	Rn.10495
ProteinModelPortal	Q8CG09
SMR	Q8CG09
STRING	10116.ENSRNOP00000045518
ChEMBL	CHEMBL5680
PhosphoSite	Q8CG09
PaxDb	Q8CG09
PRIDE	Q8CG09
GeneID	24565
KEGG	rno:24565
UCSC	RGD:3112
CTD	4363
RGD	3112
eggNOG	COG1132
HOVERGEN	HBG108314
InParanoid	Q8CG09
KO	K05665
PhylomeDB	Q8CG09
NextBio	603696
PRO	PR:Q8CG09
Proteomes	UP000002494
Genevestigator	Q8CG09
GO	GO:0016323 GO:0005737 GO:0005887 GO:0016020 GO:0005886 GO:0005524 GO:0015238 GO:0015562 GO:0015431 GO:0034634 GO:0034040 GO:0005324 GO:0016491 GO:0046624 GO:0008559 GO:0060326 GO:0043215 GO:0046618 GO:0006855 GO:0034775 GO:1901215 GO:0033700 GO:0015911 GO:0030335 GO:0042493 GO:0006979 GO:0055085 GO:0042908
Gene3D	3.40.50.300
InterPro	IPR003593 IPR011527 IPR003439 IPR017871 IPR030241 IPR018170 IPR005292 IPR027417
PANTHER	PTHR24223:SF203
Pfam	PF00664 PF00005
SMART	SM00382
SUPFAM	SSF52540 SSF90123
TIGRFAMs	TIGR00957
PROSITE	PS50929 PS00211 PS50893 PS00063

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0016323	basolateral plasma membrane	PMID:24130369^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:1905701	positive regulation of drug transmembrane export	PMID:15198509^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
	GO:0016323	basolateral plasma membrane	PMID:24130369^[1]	ECO:0000314			C	Figure 1 A and B.	complete CACAO 9060
involved_in	GO:1901215	negative regulation of neuron death	PMID:17141959^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	PMID:15198509^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060326	cell chemotaxis	PMID:17050692^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	PMID:12423064^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0046624	sphingolipid transporter activity	PMID:17050692^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0046618	drug export	PMID:17854063^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046618	drug export	PMID:12423064^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042908	xenobiotic transport	PMID:12893836^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:14641820^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034775	glutathione transmembrane transport	PMID:19053318^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034775	glutathione transmembrane transport	PMID:12125073^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0034634	glutathione transmembrane transporter activity	PMID:12125073^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0034040	lipid-transporting ATPase activity	PMID:12867490^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0033700	phospholipid efflux	PMID:17050692^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:17050692^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:17854063^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:11804835^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:12893836^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0015911	long-chain fatty acid import across plasma membrane	PMID:12867490^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0015562	efflux transmembrane transporter activity	PMID:12423064^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0015238	drug transmembrane transporter activity	PMID:17854063^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008559	xenobiotic transmembrane transporting ATPase activity	PMID:12893836^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008559	xenobiotic transmembrane transporting ATPase activity	PMID:12867490^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	PMID:11208926^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006855	drug transmembrane transport	PMID:17854063^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:17854063^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:11804835^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11804835^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005324	long-chain fatty acid transporter activity	PMID:12867490^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000657997 RGD:3112 SGD:S000002542 TAIR:locus:2061559 UniProtKB:A7KVC2 UniProtKB:Q10RX7	P	Seeded From UniProt	complete
involved_in	GO:0042908	xenobiotic transport	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000658334 RGD:3112	P	Seeded From UniProt	complete
enables	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000657997 RGD:71101 TAIR:locus:2061559 UniProtKB:Q9LK64	F	Seeded From UniProt	complete
involved_in	GO:0034775	glutathione transmembrane transport	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000658336 RGD:3112	P	Seeded From UniProt	complete
enables	GO:0034634	glutathione transmembrane transporter activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000658336 RGD:3112	F	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000658318 RGD:3112 UniProtKB:P33527	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352447 PANTHER:PTN000657997 RGD:2366 RGD:3112 RGD:620268 UniProtKB:O15439 UniProtKB:O15440	C	Seeded From UniProt	complete
enables	GO:0008559	xenobiotic transmembrane transporting ATPase activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000658334 RGD:3112	F	Seeded From UniProt	complete
involved_in	GO:0006855	drug transmembrane transport	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000658334 RGD:3112	P	Seeded From UniProt	complete
part_of	GO:0005774	vacuolar membrane	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001954664 TAIR:locus:2043268 TAIR:locus:2061559 TAIR:locus:2077750 TAIR:locus:2081755 TAIR:locus:2090039 TAIR:locus:2090049 TAIR:locus:2094721 TAIR:locus:2204202 UniProtKB:Q7GB25 UniProtKB:Q9LK64	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003439 InterPro:IPR011527 InterPro:IPR017871 InterPro:IPR036640	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005292 InterPro:IPR011527 InterPro:IPR036640	C	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018170	F	Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003439 InterPro:IPR017871	F	Seeded From UniProt	complete
enables	GO:0022857	transmembrane transporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005292	F	Seeded From UniProt	complete
enables	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011527	F	Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005292 InterPro:IPR011527	P	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018170	P	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Klein, DM et al. (2014) Localization of multidrug resistance-associated proteins along the blood-testis barrier in rat, macaque, and human testis. Drug Metab. Dispos. 42 89-93 PubMed GONUTS page
↑ ^2.0 ^2.1 Yang, Z et al. (2004) Development and characterization of a recombinant Madin-Darby canine kidney cell line that expresses rat multidrug resistance-associated protein 1 (rMRP1). AAPS PharmSci 6 E8 PubMed GONUTS page
↑ Falcão, AS et al. (2007) Role of multidrug resistance-associated protein 1 expression in the in vitro susceptibility of rat nerve cell to unconjugated bilirubin. Neuroscience 144 878-88 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Mitra, P et al. (2006) Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. Proc. Natl. Acad. Sci. U.S.A. 103 16394-9 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Yang, Z et al. (2002) Cloning and characterization of the rat multidrug resistance-associated protein 1. AAPS PharmSci 4 E15 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Patel, LN et al. (2008) Molecular and functional expression of multidrug resistance-associated protein-1 in primary cultured rat alveolar epithelial cells. J Pharm Sci 97 2340-9 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Dallas, S et al. (2003) Functional expression of the multidrug resistance protein 1 in microglia. J. Pharmacol. Exp. Ther. 307 282-90 PubMed GONUTS page
↑ Takayanagi, S & Ishikawa, T () Molecular identification and characterization of rat Abcc1 cDNA: existence of two splicing variants and species difference in drug-resistance profile. J. Exp. Ther. Oncol. 3 136-46 PubMed GONUTS page
↑ Costa, VM et al. (2009) Cross-functioning between the extraneuronal monoamine transporter and multidrug resistance protein 1 in the uptake of adrenaline and export of 5-(glutathion-S-yl)adrenaline in rat cardiomyocytes. Chem. Res. Toxicol. 22 129-135 PubMed GONUTS page
↑ ^10.0 ^10.1 Hirrlinger, J et al. (2002) Glutathione release from cultured brain cells: multidrug resistance protein 1 mediates the release of GSH from rat astroglial cells. J. Neurosci. Res. 69 318-26 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Nunoya, K et al. (2003) Molecular cloning and pharmacological characterization of rat multidrug resistance protein 1 (mrp1). Drug Metab. Dispos. 31 1016-26 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Pei, QL et al. (2002) Increased expression of multidrug resistance-associated protein 1 (mrp1) in hepatocyte basolateral membrane and renal tubular epithelia after bile duct ligation in rats. Hepatol. Res. 22 58-64 PubMed GONUTS page
↑ Hirrlinger, J et al. (2001) The multidrug resistance protein MRP1 mediates the release of glutathione disulfide from rat astrocytes during oxidative stress. J. Neurochem. 76 627-36 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 ^14.8 ^14.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24130369-1] 1.0 ^1.1 Klein, DM et al. (2014) Localization of multidrug resistance-associated proteins along the blood-testis barrier in rat, macaque, and human testis. Drug Metab. Dispos. 42 89-93 PubMed GONUTS page

[PMID:15198509-2] 2.0 ^2.1 Yang, Z et al. (2004) Development and characterization of a recombinant Madin-Darby canine kidney cell line that expresses rat multidrug resistance-associated protein 1 (rMRP1). AAPS PharmSci 6 E8 PubMed GONUTS page

[PMID:17141959-3] Falcão, AS et al. (2007) Role of multidrug resistance-associated protein 1 expression in the in vitro susceptibility of rat nerve cell to unconjugated bilirubin. Neuroscience 144 878-88 PubMed GONUTS page

[PMID:17050692-4] 4.0 ^4.1 ^4.2 ^4.3 Mitra, P et al. (2006) Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. Proc. Natl. Acad. Sci. U.S.A. 103 16394-9 PubMed GONUTS page

[PMID:12423064-5] 5.0 ^5.1 ^5.2 Yang, Z et al. (2002) Cloning and characterization of the rat multidrug resistance-associated protein 1. AAPS PharmSci 4 E15 PubMed GONUTS page

[PMID:17854063-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Patel, LN et al. (2008) Molecular and functional expression of multidrug resistance-associated protein-1 in primary cultured rat alveolar epithelial cells. J Pharm Sci 97 2340-9 PubMed GONUTS page

[PMID:12893836-7] 7.0 ^7.1 ^7.2 Dallas, S et al. (2003) Functional expression of the multidrug resistance protein 1 in microglia. J. Pharmacol. Exp. Ther. 307 282-90 PubMed GONUTS page

[PMID:14641820-8] Takayanagi, S & Ishikawa, T () Molecular identification and characterization of rat Abcc1 cDNA: existence of two splicing variants and species difference in drug-resistance profile. J. Exp. Ther. Oncol. 3 136-46 PubMed GONUTS page

[PMID:19053318-9] Costa, VM et al. (2009) Cross-functioning between the extraneuronal monoamine transporter and multidrug resistance protein 1 in the uptake of adrenaline and export of 5-(glutathion-S-yl)adrenaline in rat cardiomyocytes. Chem. Res. Toxicol. 22 129-135 PubMed GONUTS page

[PMID:12125073-10] 10.0 ^10.1 Hirrlinger, J et al. (2002) Glutathione release from cultured brain cells: multidrug resistance protein 1 mediates the release of GSH from rat astroglial cells. J. Neurosci. Res. 69 318-26 PubMed GONUTS page

[PMID:12867490-11] 11.0 ^11.1 ^11.2 ^11.3 Nunoya, K et al. (2003) Molecular cloning and pharmacological characterization of rat multidrug resistance protein 1 (mrp1). Drug Metab. Dispos. 31 1016-26 PubMed GONUTS page

[PMID:11804835-12] 12.0 ^12.1 ^12.2 Pei, QL et al. (2002) Increased expression of multidrug resistance-associated protein 1 (mrp1) in hepatocyte basolateral membrane and renal tubular epithelia after bile duct ligation in rats. Hepatol. Res. 22 58-64 PubMed GONUTS page

[PMID:11208926-13] Hirrlinger, J et al. (2001) The multidrug resistance protein MRP1 mediates the release of glutathione disulfide from rat astrocytes during oxidative stress. J. Neurochem. 76 627-36 PubMed GONUTS page

[PMID:21873635-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 ^14.8 ^14.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:MRP1

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