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RAT:MGLL
Contents
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Mgll (synonyms: Mgl2) | |
| Protein Name(s) | Monoglyceride lipase
MGL Monoacylglycerol lipase MAGL | |
| External Links | ||
| UniProt | Q8R431 | |
| EMBL | AY081195 BC107920 | |
| RefSeq | NP_612511.1 | |
| UniGene | Rn.40396 | |
| ProteinModelPortal | Q8R431 | |
| MINT | MINT-4580167 | |
| BindingDB | Q8R431 | |
| ChEMBL | CHEMBL3321 | |
| MEROPS | S33.980 | |
| PhosphoSite | Q8R431 | |
| PaxDb | Q8R431 | |
| PRIDE | Q8R431 | |
| Ensembl | ENSRNOT00000029125 | |
| GeneID | 29254 | |
| KEGG | rno:29254 | |
| UCSC | RGD:71039 | |
| CTD | 11343 | |
| RGD | 71039 | |
| eggNOG | COG2267 | |
| GeneTree | ENSGT00390000011364 | |
| HOGENOM | HOG000003227 | |
| HOVERGEN | HBG049220 | |
| InParanoid | Q8R431 | |
| KO | K01054 | |
| OMA | HGASEYH | |
| OrthoDB | EOG7WT41N | |
| PhylomeDB | Q8R431 | |
| BRENDA | 3.1.1.23 | |
| Reactome | REACT_199136 REACT_236244 REACT_246375 | |
| UniPathway | UPA00256 | |
| NextBio | 608558 | |
| PRO | PR:Q8R431 | |
| Proteomes | UP000002494 | |
| Genevestigator | Q8R431 | |
| GO | GO:0005811 GO:0045202 GO:0047372 GO:0016787 GO:0008289 GO:0046464 GO:0019369 GO:0006633 GO:0060292 GO:2000124 GO:0050727 GO:0051930 GO:0009966 GO:0019433 | |
| Gene3D | 3.40.50.1820 | |
| InterPro | IPR029058 IPR000073 IPR022742 | |
| Pfam | PF12146 | |
| PRINTS | PR00111 | |
| SUPFAM | SSF53474 | |
| PROSITE | PS00120 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0052651 |
monoacylglycerol catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0047372 |
acylglycerol lipase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019898 |
extrinsic component of membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051930 |
regulation of sensory perception of pain |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050727 |
regulation of inflammatory response |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0047372 |
acylglycerol lipase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046464 |
acylglycerol catabolic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019369 |
arachidonic acid metabolic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009966 |
regulation of signal transduction |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0097756 |
negative regulation of blood vessel diameter |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045202 |
synapse |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0047372 |
acylglycerol lipase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1346042 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016020 |
membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10739 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0047372 |
acylglycerol lipase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0047372 |
acylglycerol lipase activity |
Reactome:R-RNO-163439 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005811 |
lipid droplet |
Reactome:R-RNO-163439 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006633 |
fatty acid biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0052689 |
carboxylic ester hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006631 |
fatty acid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016042 |
lipid catabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019433 |
triglyceride catabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00256 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Vila, A et al. (2007) Hydrolysis of prostaglandin glycerol esters by the endocannabinoid-hydrolyzing enzymes, monoacylglycerol lipase and fatty acid amide hydrolase. Biochemistry 46 9578-85 PubMed GONUTS page
- ↑ Ho, WS & Randall, MD (2007) Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol. Br. J. Pharmacol. 150 641-51 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Dinh, TP et al. (2002) Brain monoglyceride lipase participating in endocannabinoid inactivation. Proc. Natl. Acad. Sci. U.S.A. 99 10819-24 PubMed GONUTS page
- ↑ 4.0 4.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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