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RAT:LIF
Contents
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Lif | |
| Protein Name(s) | Leukemia inhibitory factor
LIF Cholinergic neuronal differentiation factor | |
| External Links | ||
| UniProt | P17777 | |
| EMBL | M32748 | |
| PIR | A40078 | |
| UniGene | Rn.44379 | |
| ProteinModelPortal | P17777 | |
| SMR | P17777 | |
| PRIDE | P17777 | |
| UCSC | RGD:620865 | |
| RGD | 620865 | |
| eggNOG | NOG45686 | |
| HOGENOM | HOG000059647 | |
| HOVERGEN | HBG006267 | |
| InParanoid | P17777 | |
| PhylomeDB | P17777 | |
| PRO | PR:P17777 | |
| Proteomes | UP000002494 | |
| Genevestigator | P17777 | |
| GO | GO:0005615 GO:0005146 GO:0048708 GO:0006955 GO:0016525 GO:0031100 GO:0051461 GO:0010976 GO:0060041 GO:0060290 | |
| Gene3D | 1.20.1250.10 | |
| InterPro | IPR009079 IPR012351 IPR003624 IPR001581 IPR019827 | |
| PANTHER | PTHR10633 | |
| Pfam | PF01291 | |
| PRINTS | PR01883 | |
| SMART | SM00080 | |
| SUPFAM | SSF47266 | |
| PROSITE | PS00590 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0042511 |
positive regulation of tyrosine phosphorylation of Stat1 protein |
ECO:0000314 |
P |
B-C. LIF activates STAT1 in MM. |
complete | |||||
| GO:0042517 |
positive regulation of tyrosine phosphorylation of Stat3 protein |
ECO:0000314 |
P |
LIF activates STAT3 in MM |
complete | |||||
|
Contributes to |
GO:0072162 |
metanephric mesenchymal cell differentiation |
ECO:0000314 |
P |
"...indicating that STAT1 is also activated in early renal development". (Since LIF is upstream of STAT1, it contributes to metanephric mesenchymal cell differentiation by activating STAT1). |
complete | ||||
| GO:0051091 |
positive regulation of transcription factor activity |
ECO:0000314 |
P |
As shown in Fig.3A, LIF ...induced the expression of LIM-1. "The Lim-1 gene encodes a LIM-homeodomain transcription factor that is highly conserved among vertebrates". definition from PMID:12454922[2].
|
complete | |||||
| GO:0046587 |
positive regulation of calcium-dependent cell-cell adhesion |
ECO:0000314 |
P |
..we also evaluated expression of lim-1 and E-cadherin by immunoblotting. Expression of both markers was induced with LIF treatment. E-cadherin - definition from UniProt Cadherins are calcium-dependent cell adhesion proteins
|
complete | |||||
|
involved_in |
GO:0060290 |
transdifferentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060041 |
retina development in camera-type eye |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051461 |
positive regulation of corticotropin secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048708 |
astrocyte differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031100 |
animal organ regeneration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031100 |
animal organ regeneration |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016525 |
negative regulation of angiogenesis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010976 |
positive regulation of neuron projection development |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005146 |
leukemia inhibitory factor receptor binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048861 |
leukemia inhibitory factor signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000067074 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045595 |
regulation of cell differentiation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96787 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96787 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008083 |
growth factor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96787 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000067074 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005146 |
leukemia inhibitory factor receptor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000067074 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96787 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0008083 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0008083 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005146 |
leukemia inhibitory factor receptor binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006955 |
immune response |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008083 |
growth factor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Wang, H et al. (2010) STAT1 activation regulates proliferation and differentiation of renal progenitors. Cell. Signal. 22 1717-26 PubMed GONUTS page
- ↑ Watanabe, M et al. (2002) Regulation of the Lim-1 gene is mediated through conserved FAST-1/FoxH1 sites in the first intron. Dev. Dyn. 225 448-56 PubMed GONUTS page
- ↑ Kanazawa, H et al. (2010) Heart failure causes cholinergic transdifferentiation of cardiac sympathetic nerves via gp130-signaling cytokines in rodents. J. Clin. Invest. 120 408-21 PubMed GONUTS page
- ↑ 4.0 4.1 McColm, JR et al. (2006) Exogenous leukemia inhibitory factor (LIF) attenuates retinal vascularization reducing cell proliferation not apoptosis. Exp. Eye Res. 83 438-46 PubMed GONUTS page
- ↑ 5.0 5.1 Simamura, E et al. (2010) Maternal leukemia inhibitory factor (LIF) promotes fetal neurogenesis via a LIF-ACTH-LIF signaling relay pathway. Endocrinology 151 1853-62 PubMed GONUTS page
- ↑ Nakanishi, M et al. (2007) Microglia-derived interleukin-6 and leukaemia inhibitory factor promote astrocytic differentiation of neural stem/progenitor cells. Eur. J. Neurosci. 25 649-58 PubMed GONUTS page
- ↑ 7.0 7.1 Yoshino, J et al. (2003) Leukemia inhibitory factor is involved in tubular regeneration after experimental acute renal failure. J. Am. Soc. Nephrol. 14 3090-101 PubMed GONUTS page
- ↑ De Breuck, S et al. (2006) Expression and function of leukaemia inhibitory factor and its receptor in normal and regenerating rat pancreas. Diabetologia 49 108-16 PubMed GONUTS page
- ↑ Sango, K et al. (2008) Neuroprotective properties of ciliary neurotrophic factor for cultured adult rat dorsal root ganglion neurons. Histochem. Cell Biol. 130 669-79 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 10.4 10.5 10.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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- GO:0042517 ! positive regulation of tyrosine phosphorylation of Stat3 protein
- GO:0008284 ! positive regulation of cell population proliferation
- GO:0010976 ! positive regulation of neuron projection development
- GO:0051461 ! positive regulation of corticotropin secretion
- GO:0046587 ! positive regulation of calcium-dependent cell-cell adhesion
- GO:0051091 ! positive regulation of DNA-binding transcription factor activity
- GO:0042511 ! positive regulation of tyrosine phosphorylation of Stat1 protein
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