RAT:KCC2B

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Camk2b
Protein Name(s)	Calcium/calmodulin-dependent protein kinase type II subunit beta CaM kinase II subunit beta CaMK-II subunit beta
External Links
UniProt	P08413
EMBL	M16112
PIR	A26464
RefSeq	NP_001035815.1 NP_068507.2
UniGene	Rn.9743
ProteinModelPortal	P08413
SMR	P08413
BioGrid	246430
DIP	DIP-36948N
IntAct	P08413
ChEMBL	CHEMBL2111382
PhosphoSite	P08413
PaxDb	P08413
PRIDE	P08413
GeneID	24245
KEGG	rno:24245
UCSC	RGD:2262
CTD	816
RGD	2262
eggNOG	COG0515
HOGENOM	HOG000233016
HOVERGEN	HBG108055
InParanoid	P08413
KO	K04515
PhylomeDB	P08413
BRENDA	2.7.11.17
NextBio	602737
Proteomes	UP000002494
Genevestigator	P08413
GO	GO:0005815 GO:0033017 GO:0005524 GO:0004683 GO:0060291 GO:0061003 GO:0010976 GO:0090129 GO:0046777
InterPro	IPR020636 IPR013543 IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
PANTHER	PTHR24347
Pfam	PF08332 PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:2001222	regulation of neuron migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13554	P		Seeded From UniProt	complete
involved_in	GO:1903076	regulation of protein localization to plasma membrane	PMID:19188609^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134,UniProtKB:P11275,UniProtKB:P11730,UniProtKB:P15791	P	occurs_in:(CL:0002608) has_target_start_location:(GO:0032590) transports_or_maintains_localization_of:(UniProtKB:P06213) has_target_end_location:(GO:0032809)\|occurs_in(CL:0002608) has_target_start_location:(GO:0032590) transports_or_maintains_localization_of:(GO:0017146) has_target_end_location:(GO:0032809)	Seeded From UniProt	complete
involved_in	GO:0090129	positive regulation of synapse maturation	PMID:12873385^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061003	positive regulation of dendritic spine morphogenesis	PMID:12873385^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13554	P		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	PMID:12873385^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:17404223^[3]	ECO:0006067	fluorescence recovery after photobleaching evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:17404223^[3]	ECO:0006064	cell-free assay evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:17404223^[3]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:17404223^[3]	ECO:0006052	RNAi evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:17404223^[3]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:17404223^[3]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:17404223^[3]	ECO:0000279	western blot evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
enables	GO:0098973	structural constituent of postsynaptic actin cytoskeleton	PMID:17404223^[3]	ECO:0006067	fluorescence recovery after photobleaching evidence used in manual assertion		F	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
enables	GO:0098973	structural constituent of postsynaptic actin cytoskeleton	PMID:17404223^[3]	ECO:0006064	cell-free assay evidence used in manual assertion		F	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
enables	GO:0098973	structural constituent of postsynaptic actin cytoskeleton	PMID:17404223^[3]	ECO:0006063	over expression analysis evidence used in manual assertion		F	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
enables	GO:0098973	structural constituent of postsynaptic actin cytoskeleton	PMID:17404223^[3]	ECO:0006052	RNAi evidence used in manual assertion		F	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
enables	GO:0098973	structural constituent of postsynaptic actin cytoskeleton	PMID:17404223^[3]	ECO:0006042	cell fractionation evidence used in manual assertion		F	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
enables	GO:0098973	structural constituent of postsynaptic actin cytoskeleton	PMID:17404223^[3]	ECO:0006003	electron microscopy evidence used in manual assertion		F	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
enables	GO:0098973	structural constituent of postsynaptic actin cytoskeleton	PMID:17404223^[3]	ECO:0000279	western blot evidence used in manual assertion		F	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:20878786^[4]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(UBERON:0001890)	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:20878786^[4]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0001890)	Seeded From UniProt	complete
involved_in	GO:1990911	response to psychosocial stress	PMID:23313435^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1905375	cellular response to homocysteine	PMID:25126162^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0110088	hippocampal neuron apoptotic process	PMID:25126162^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048858	cell projection morphogenesis	PMID:23785157^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043274	phospholipase binding	PMID:15576376^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	PMID:7820660^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032430	positive regulation of phospholipase A2 activity	PMID:15576376^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:7820660^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:20841359^[10]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:620351 RGD:70982	F		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:7820660^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004683	calmodulin-dependent protein kinase activity	PMID:15576376^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002389359 WB:WBGene00006779	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1341265 PANTHER:PTN002389359 RGD:2263	C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88256 PANTHER:PTN002389359 UniProtKB:Q13557 UniProtKB:Q9UQM7	F		Seeded From UniProt	complete
enables	GO:0004683	calmodulin-dependent protein kinase activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0264607 MGI:MGI:88256 MGI:MGI:88257 PANTHER:PTN002389359 RGD:2261 RGD:2262 RGD:2263 RGD:621802 UniProtKB:Q13557 UniProtKB:Q9UQM7 WB:WBGene00006779	F		Seeded From UniProt	complete
involved_in	GO:0060291	long-term synaptic potentiation	PMID:2549638^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0098974	postsynaptic actin cytoskeleton organization	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0098973	P		Seeded From UniProt	complete
involved_in	GO:0098974	postsynaptic actin cytoskeleton organization	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0098973	P		Seeded From UniProt	complete
involved_in	GO:0098974	postsynaptic actin cytoskeleton organization	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0098973	P		Seeded From UniProt	complete
involved_in	GO:0098974	postsynaptic actin cytoskeleton organization	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0098973	P		Seeded From UniProt	complete
involved_in	GO:0098974	postsynaptic actin cytoskeleton organization	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0098973	P		Seeded From UniProt	complete
involved_in	GO:0098974	postsynaptic actin cytoskeleton organization	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0098973	P		Seeded From UniProt	complete
involved_in	GO:0098974	postsynaptic actin cytoskeleton organization	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0098973	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039071	F		Seeded From UniProt	complete
enables	GO:0004683	calmodulin-dependent protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013543 InterPro:IPR039071	F		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013543	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271 InterPro:IPR013543	P		Seeded From UniProt	complete
enables	GO:0004683	calmodulin-dependent protein kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.17	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-RNO-9618659 Reactome:R-RNO-9618616 Reactome:R-RNO-9618605 Reactome:R-RNO-9617322	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0703	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0112	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C		Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0241	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ De Felice, FG et al. (2009) Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers. Proc. Natl. Acad. Sci. U.S.A. 106 1971-6 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Fink, CC et al. (2003) Selective regulation of neurite extension and synapse formation by the beta but not the alpha isoform of CaMKII. Neuron 39 283-97 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 Okamoto, K et al. (2007) The role of CaMKII as an F-actin-bundling protein crucial for maintenance of dendritic spine structure. Proc. Natl. Acad. Sci. U.S.A. 104 6418-23 PubMed GONUTS page
↑ ^4.0 ^4.1 Swulius, MT et al. (2010) Structure and composition of the postsynaptic density during development. J. Comp. Neurol. 518 4243-60 PubMed GONUTS page
↑ Novak, G et al. (2013) Postnatal maternal deprivation and pubertal stress have additive effects on dopamine D2 receptor and CaMKII beta expression in the striatum. Int. J. Dev. Neurosci. 31 189-95 PubMed GONUTS page
↑ ^6.0 ^6.1 Fang, M et al. (2014) Camk2b protects neurons from homocysteine-induced apoptosis with the involvement of HIF-1α signal pathway. Int J Clin Exp Med 7 1659-68 PubMed GONUTS page
↑ Waggener, CT et al. (2013) CaMKIIβ regulates oligodendrocyte maturation and CNS myelination. J. Neurosci. 33 10453-8 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Wang, Z et al. (2005) Group VIA phospholipase A2 forms a signaling complex with the calcium/calmodulin-dependent protein kinase IIbeta expressed in pancreatic islet beta-cells. J. Biol. Chem. 280 6840-9 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Ochiishi, T et al. (1994) Specific distribution of Ca2+/calmodulin-dependent protein kinase II alpha and beta isoforms in some structures of the rat forebrain. Brain Res. 659 179-93 PubMed GONUTS page
↑ Song, B et al. (2010) Inhibitory phosphorylation of GSK-3 by CaMKII couples depolarization to neuronal survival. J. Biol. Chem. 285 41122-34 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Malinow, R et al. (1989) Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP. Science 245 862-6 PubMed GONUTS page

[PMID:19188609-1] De Felice, FG et al. (2009) Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers. Proc. Natl. Acad. Sci. U.S.A. 106 1971-6 PubMed GONUTS page

[PMID:12873385-2] 2.0 ^2.1 ^2.2 Fink, CC et al. (2003) Selective regulation of neurite extension and synapse formation by the beta but not the alpha isoform of CaMKII. Neuron 39 283-97 PubMed GONUTS page

[PMID:17404223-3] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 Okamoto, K et al. (2007) The role of CaMKII as an F-actin-bundling protein crucial for maintenance of dendritic spine structure. Proc. Natl. Acad. Sci. U.S.A. 104 6418-23 PubMed GONUTS page

[PMID:20878786-4] 4.0 ^4.1 Swulius, MT et al. (2010) Structure and composition of the postsynaptic density during development. J. Comp. Neurol. 518 4243-60 PubMed GONUTS page

[PMID:23313435-5] Novak, G et al. (2013) Postnatal maternal deprivation and pubertal stress have additive effects on dopamine D2 receptor and CaMKII beta expression in the striatum. Int. J. Dev. Neurosci. 31 189-95 PubMed GONUTS page

[PMID:25126162-6] 6.0 ^6.1 Fang, M et al. (2014) Camk2b protects neurons from homocysteine-induced apoptosis with the involvement of HIF-1α signal pathway. Int J Clin Exp Med 7 1659-68 PubMed GONUTS page

[PMID:23785157-7] Waggener, CT et al. (2013) CaMKIIβ regulates oligodendrocyte maturation and CNS myelination. J. Neurosci. 33 10453-8 PubMed GONUTS page

[PMID:15576376-8] 8.0 ^8.1 ^8.2 Wang, Z et al. (2005) Group VIA phospholipase A2 forms a signaling complex with the calcium/calmodulin-dependent protein kinase IIbeta expressed in pancreatic islet beta-cells. J. Biol. Chem. 280 6840-9 PubMed GONUTS page

[PMID:7820660-9] 9.0 ^9.1 ^9.2 Ochiishi, T et al. (1994) Specific distribution of Ca2+/calmodulin-dependent protein kinase II alpha and beta isoforms in some structures of the rat forebrain. Brain Res. 659 179-93 PubMed GONUTS page

[PMID:20841359-10] Song, B et al. (2010) Inhibitory phosphorylation of GSK-3 by CaMKII couples depolarization to neuronal survival. J. Biol. Chem. 285 41122-34 PubMed GONUTS page

[PMID:21873635-11] 11.0 ^11.1 ^11.2 ^11.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:2549638-12] Malinow, R et al. (1989) Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP. Science 245 862-6 PubMed GONUTS page

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RAT:KCC2B

Contents

Annotations

Notes

References

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