RAT:ITPR2

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Itpr2
Protein Name(s)	Inositol 1,4,5-trisphosphate receptor type 2 IP3 receptor isoform 2 IP3R 2 InsP3R2 Type 2 inositol 1,4,5-trisphosphate receptor Type 2 InsP3 receptor
External Links
UniProt	P29995
EMBL	X61677 AF329470
PIR	S17796
RefSeq	NP_112308.1
UniGene	Rn.89152
ProteinModelPortal	P29995
SMR	P29995
BioGrid	249575
GuidetoPHARMACOLOGY	744
TCDB	1.A.3.2.1
PaxDb	P29995
PRIDE	P29995
GeneID	81678
KEGG	rno:81678
UCSC	RGD:69649
CTD	3709
RGD	69649
eggNOG	NOG280601
HOGENOM	HOG000007660
HOVERGEN	HBG052158
InParanoid	P29995
KO	K04959
PhylomeDB	P29995
Reactome	REACT_194374 REACT_194690 REACT_203734 REACT_211910 REACT_220575 REACT_221588 REACT_234414 REACT_247187
NextBio	615288
PRO	PR:P29995
Proteomes	UP000002494
Genevestigator	P29995
GO	GO:0030424 GO:0005737 GO:0005783 GO:0005789 GO:0016021 GO:0043209 GO:0016529 GO:0005509 GO:0070679 GO:0005220 GO:0071456 GO:0048016
Gene3D	1.25.10.30
InterPro	IPR016024 IPR014821 IPR000493 IPR005821 IPR016093 IPR013662 IPR000699 IPR015925
PANTHER	PTHR13715
Pfam	PF08709 PF00520 PF02815 PF08454 PF01365
PRINTS	PR00779
SMART	SM00472
SUPFAM	SSF100909 SSF48371 SSF82109
PROSITE	PS50919

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0051209	release of sequestered calcium ion into cytosol	PMID:23166348^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002131)	Seeded From UniProt	complete
enables	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	PMID:23166348^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(CL:0002131)	Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	PMID:17285299^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070679	inositol 1,4,5 trisphosphate binding	PMID:17081354^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0070679	inositol 1,4,5 trisphosphate binding	PMID:10969001^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0043209	myelin sheath	PMID:17091480^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:17091480^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	PMID:16014380^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:15533917^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:10969001^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:17091480^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:17081354^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17091480^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:10969001^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	PMID:15533917^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	PMID:10969001^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0070679	inositol 1,4,5 trisphosphate binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001010185 RGD:2934 RGD:69649 UniProtKB:Q14573	F		Seeded From UniProt	complete
involved_in	GO:0051209	release of sequestered calcium ion into cytosol	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010051 MGI:MGI:96623 MGI:MGI:99659 PANTHER:PTN001416417 RGD:1586637 RGD:2933 RGD:69649 UniProtKB:P21817 UniProtKB:Q92736	P		Seeded From UniProt	complete
enables	GO:0035091	phosphatidylinositol binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96623 MGI:MGI:96624 MGI:MGI:99418 PANTHER:PTN001010185	F		Seeded From UniProt	complete
part_of	GO:0030667	secretory granule membrane	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001010185 RGD:2933 UniProtKB:Q8WN96	C		Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000346459 dictyBase:DDB_G0292564	C		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96623 MGI:MGI:99418 PANTHER:PTN001010185 RGD:2933 RGD:69649	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001416417 RGD:2933 RGD:620314 UniProtKB:P21817 UniProtKB:Q14571 UniProtKB:Q14573	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96623 MGI:MGI:96624 PANTHER:PTN001010185 RGD:2933 RGD:2934 RGD:69649 UniProtKB:Q14573	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001416417 RGD:2934 RGD:69649	F		Seeded From UniProt	complete
enables	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010051 MGI:MGI:96623 MGI:MGI:96624 MGI:MGI:99418 PANTHER:PTN001010185 RGD:2933 RGD:2934 RGD:69649 UniProtKB:Q14573	F		Seeded From UniProt	complete
involved_in	GO:0048016	inositol phosphate-mediated signaling	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005220	P		Seeded From UniProt	complete
involved_in	GO:0048016	inositol phosphate-mediated signaling	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005220	P		Seeded From UniProt	complete
involved_in	GO:0048016	inositol phosphate-mediated signaling	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005220	P		Seeded From UniProt	complete
involved_in	GO:0048016	inositol phosphate-mediated signaling	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005220	P		Seeded From UniProt	complete
involved_in	GO:0048016	inositol phosphate-mediated signaling	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005220	P		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	F		Seeded From UniProt	complete
enables	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000493	F		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000699	F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000493	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000493 InterPro:IPR015925	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000699 InterPro:IPR005821 InterPro:IPR016093 InterPro:IPR036300	C		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000699	P		Seeded From UniProt	complete
enables	GO:0070679	inositol 1,4,5 trisphosphate binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000493	F		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	Reactome:R-RNO-182097 Reactome:R-RNO-182052	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0109	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Drawnel, FM et al. (2012) Mutual antagonism between IP(3)RII and miRNA-133a regulates calcium signals and cardiac hypertrophy. J. Cell Biol. 199 783-98 PubMed GONUTS page
↑ Jurkovicova, D et al. (2007) Hypoxia modulates gene expression of IP3 receptors in rodent cerebellum. Pflugers Arch. 454 415-25 PubMed GONUTS page
↑ ^3.0 ^3.1 Endo, Y et al. (2006) Organelles containing inositol trisphosphate receptor type 2 in adrenal medullary cells. J Physiol Sci 56 415-23 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Ramos-Franco, J et al. (2000) Single-channel function of recombinant type 2 inositol 1,4, 5-trisphosphate receptor. Biophys. J. 79 1388-99 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Toews, JC et al. (2007) Signaling proteins in the axoglial apparatus of sciatic nerve nodes of Ranvier. Glia 55 202-13 PubMed GONUTS page
↑ Cárdenas, C et al. (2005) Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation. J. Cell. Sci. 118 3131-40 PubMed GONUTS page
↑ ^7.0 ^7.1 Tu, H et al. (2005) Functional characterization of mammalian inositol 1,4,5-trisphosphate receptor isoforms. Biophys. J. 88 1046-55 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 ^8.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23166348-1] 1.0 ^1.1 Drawnel, FM et al. (2012) Mutual antagonism between IP(3)RII and miRNA-133a regulates calcium signals and cardiac hypertrophy. J. Cell Biol. 199 783-98 PubMed GONUTS page

[PMID:17285299-2] Jurkovicova, D et al. (2007) Hypoxia modulates gene expression of IP3 receptors in rodent cerebellum. Pflugers Arch. 454 415-25 PubMed GONUTS page

[PMID:17081354-3] 3.0 ^3.1 Endo, Y et al. (2006) Organelles containing inositol trisphosphate receptor type 2 in adrenal medullary cells. J Physiol Sci 56 415-23 PubMed GONUTS page

[PMID:10969001-4] 4.0 ^4.1 ^4.2 ^4.3 Ramos-Franco, J et al. (2000) Single-channel function of recombinant type 2 inositol 1,4, 5-trisphosphate receptor. Biophys. J. 79 1388-99 PubMed GONUTS page

[PMID:17091480-5] 5.0 ^5.1 ^5.2 ^5.3 Toews, JC et al. (2007) Signaling proteins in the axoglial apparatus of sciatic nerve nodes of Ranvier. Glia 55 202-13 PubMed GONUTS page

[PMID:16014380-6] Cárdenas, C et al. (2005) Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation. J. Cell. Sci. 118 3131-40 PubMed GONUTS page

[PMID:15533917-7] 7.0 ^7.1 Tu, H et al. (2005) Functional characterization of mammalian inositol 1,4,5-trisphosphate receptor isoforms. Biophys. J. 88 1046-55 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 ^8.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:ITPR2

Contents

Annotations

Notes

References

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