RAT:INS1

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Ins1 (synonyms: Ins-1)
Protein Name(s)	Insulin-1 Insulin-1 B chain Insulin-1 A chain
External Links
UniProt	P01322
EMBL	V01242 J00747 M25584
PIR	A90788
RefSeq	NP_062002.1
UniGene	Rn.962
ProteinModelPortal	P01322
SMR	P01322
STRING	10116.ENSRNOP00000016052
PaxDb	P01322
Ensembl	ENSRNOT00000016052
GeneID	24505
KEGG	rno:24505
UCSC	RGD:2915
CTD	16333
RGD	2915
eggNOG	NOG45999
GeneTree	ENSGT00390000015440
HOGENOM	HOG000261669
HOVERGEN	HBG006137
InParanoid	P01322
KO	K04526
OMA	DPQVGQV
OrthoDB	EOG7TF7CG
PhylomeDB	P01322
TreeFam	TF332820
Reactome	REACT_274049 REACT_275576 REACT_276026 REACT_289184 REACT_291993 REACT_295378 REACT_331521 REACT_340889 REACT_345047
NextBio	603519
PRO	PR:P01322
Proteomes	UP000002494
Genevisible	P01322
GO	GO:0005615 GO:0030141 GO:0051087 GO:0005158 GO:0002020 GO:0006006 GO:0051591 GO:0034097 GO:0010033 GO:0043434
Gene3D	1.10.100.10
InterPro	IPR004825 IPR016179 IPR022353 IPR022352
Pfam	PF00049
PRINTS	PR00277 PR00276
SMART	SM00078
SUPFAM	SSF56994
PROSITE	PS00262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0005615	extracellular space		ECO:0000314			C	Source: RGD	Missing: reference
	GO:0030141	secretory granule		ECO:0000314			C	Source: RGD	Missing: reference
	GO:0005625	soluble fraction		ECO:0000314			C	Source: RGD	Missing: reference
	GO:0051087	chaperone binding		ECO:0000021			F	Source: RGD	Missing: with/from, reference
	GO:0005158	insulin receptor binding		ECO:0000314			F	Source: RGD	Missing: reference
	GO:0002020	protease binding		ECO:0000021			F	Source: RGD	Missing: with/from, reference
	GO:0051591	response to cAMP		ECO:0000270			P	Source: RGD	Missing: reference
	GO:0034097	response to cytokine stimulus		ECO:0000270			P	Source: RGD	Missing: reference
	GO:0043434	response to peptide hormone stimulus		ECO:0000270			P	Source: RGD	Missing: reference
involved_in	GO:0051591	response to cAMP	PMID:12167488^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	PMID:10806118^[2]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:621314	F	Seeded From UniProt	complete
involved_in	GO:0043434	response to peptide hormone	PMID:12167488^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	PMID:16948396^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	PMID:10806118^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	PMID:12167488^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
colocalizes_with	GO:0005737	cytoplasm	PMID:16190983^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:12475375^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005158	insulin receptor binding	PMID:8839251^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:10806118^[2]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:3272	F	Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96573 PANTHER:PTN000155760	P	Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96573 PANTHER:PTN000155760	P	Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96573 PANTHER:PTN000155760	P	Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000155760 RGD:2915	P	Seeded From UniProt	complete
colocalizes_with	GO:0005737	cytoplasm	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96573 PANTHER:PTN000155760 RGD:2915	C	Seeded From UniProt	complete
enables	GO:0005158	insulin receptor binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000155760 RGD:2915	F	Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96573 PANTHER:PTN000155760	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01325 ensembl:ENSMUSP00000049095	C	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004825 InterPro:IPR016179 InterPro:IPR022352	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004825 InterPro:IPR016179	C	Seeded From UniProt	complete
involved_in	GO:0005975	carbohydrate metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0119	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0372	F	Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0313	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Kemp, DM & Habener, JF (2002) Synergistic effect of dimethyl sulfoxide on glucagon-like peptide 1 (GLP-1)-stimulated insulin secretion and gene transcription in INS-1 cells: characterization and implications. Biochem. Pharmacol. 64 689-97 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Arias, AE et al. (2000) Colocalization of chaperone Cpn60, proinsulin and convertase PC1 within immature secretory granules of insulin-secreting cells suggests a role for Cpn60 in insulin processing. J. Cell. Sci. 113 ( Pt 11) 2075-83 PubMed GONUTS page
↑ Chin-Chance, CV et al. (2006) Role of the mitogen-activated protein kinases in cytokine-mediated inhibition of insulin gene expression. J. Investig. Med. 54 132-42 PubMed GONUTS page
↑ Ivarsson, R et al. (2005) Myosin 5a controls insulin granule recruitment during late-phase secretion. Traffic 6 1027-35 PubMed GONUTS page
↑ Guest, PC et al. (2002) Proinsulin processing in the diabetic Goto-Kakizaki rat. J. Endocrinol. 175 637-47 PubMed GONUTS page
↑ Jehle, PM et al. (1995) Effects of glucagon-like peptide-1 (GLP-1) in RINm5F insulinoma cells. Stimulation of insulin secretion, insulin content, and insulin receptor binding. Exp. Clin. Endocrinol. Diabetes 103 Suppl 2 31-6 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12167488-1] 1.0 ^1.1 ^1.2 Kemp, DM & Habener, JF (2002) Synergistic effect of dimethyl sulfoxide on glucagon-like peptide 1 (GLP-1)-stimulated insulin secretion and gene transcription in INS-1 cells: characterization and implications. Biochem. Pharmacol. 64 689-97 PubMed GONUTS page

[PMID:10806118-2] 2.0 ^2.1 ^2.2 Arias, AE et al. (2000) Colocalization of chaperone Cpn60, proinsulin and convertase PC1 within immature secretory granules of insulin-secreting cells suggests a role for Cpn60 in insulin processing. J. Cell. Sci. 113 ( Pt 11) 2075-83 PubMed GONUTS page

[PMID:16948396-3] Chin-Chance, CV et al. (2006) Role of the mitogen-activated protein kinases in cytokine-mediated inhibition of insulin gene expression. J. Investig. Med. 54 132-42 PubMed GONUTS page

[PMID:16190983-4] Ivarsson, R et al. (2005) Myosin 5a controls insulin granule recruitment during late-phase secretion. Traffic 6 1027-35 PubMed GONUTS page

[PMID:12475375-5] Guest, PC et al. (2002) Proinsulin processing in the diabetic Goto-Kakizaki rat. J. Endocrinol. 175 637-47 PubMed GONUTS page

[PMID:8839251-6] Jehle, PM et al. (1995) Effects of glucagon-like peptide-1 (GLP-1) in RINm5F insulinoma cells. Stimulation of insulin secretion, insulin content, and insulin receptor binding. Exp. Clin. Endocrinol. Diabetes 103 Suppl 2 31-6 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:INS1

Contents

Annotations

Notes

References

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