RAT:GSHR

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Gsr
Protein Name(s)	Glutathione reductase GR GRase
External Links
UniProt	P70619
EMBL	U73174
UniGene	Rn.19721
ProteinModelPortal	P70619
SMR	P70619
STRING	10116.ENSRNOP00000020252
PaxDb	P70619
PRIDE	P70619
UCSC	RGD:621747
RGD	621747
eggNOG	COG1249
HOGENOM	HOG000276712
HOVERGEN	HBG004959
InParanoid	P70619
PhylomeDB	P70619
SABIO-RK	P70619
NextBio	13950447
PRO	PR:P70619
Proteomes	UP000002494
Genevestigator	P70619
GO	GO:0005829 GO:0005739 GO:0050660 GO:0043295 GO:0004362 GO:0050661 GO:0042803 GO:0045454 GO:0006749 GO:0045471 GO:0035094 GO:0033189 GO:0007283
Gene3D	3.30.390.30
InterPro	IPR016156 IPR013027 IPR006322 IPR004099 IPR023753 IPR001327
Pfam	PF00070 PF07992 PF02852
PRINTS	PR00368
SUPFAM	SSF55424
TIGRFAMs	TIGR01421

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0004362	glutathione-disulfide reductase activity	PMID:21930213^[1]	ECO:0000314			F	See Figure 1 for GR activity.	complete CACAO 5536
enables	GO:0004362	glutathione-disulfide reductase activity	PMID:21930213^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0050661	NADP binding	PMID:237922^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0050660	flavin adenine dinucleotide binding	PMID:237922^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0046686	response to cadmium ion	PMID:24758558^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	PMID:23905773^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0043295	glutathione binding	PMID:237922^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:237922^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	PMID:22894698^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033189	response to vitamin A	PMID:22984325^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0014823	response to activity	PMID:21621560^[7]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010041	response to iron(III) ion	PMID:24388910^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007568	aging	PMID:3106727^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	PMID:11874473^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	PMID:21704983^[11]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006749	glutathione metabolic process	PMID:237922^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:3790139^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:6659071^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004362	glutathione-disulfide reductase activity	PMID:237922^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0002931	response to ischemia	PMID:9434704^[14]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0050660	flavin adenine dinucleotide binding	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002448883 RGD:621747 UniProtKB:C8VUN9	F	Seeded From UniProt	complete
involved_in	GO:0045454	cell redox homeostasis	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002448883 PomBase:SPBC17A3.07 SGD:S000006012 dictyBase:DDB_G0272754	P	Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002448883 SGD:S000006012 UniProtKB:C8VUN9	P	Seeded From UniProt	complete
involved_in	GO:0006749	glutathione metabolic process	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002448883 PomBase:SPBC17A3.07 RGD:621747 SGD:S000006012 dictyBase:DDB_G0272754	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002448883 PomBase:SPBC17A3.07 RGD:621747 SGD:S000006012 UniProtKB:C8VUN9 WB:WBGene00008117	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000530560 PomBase:SPBC17A3.07 RGD:621747 UniProtKB:C8VUN9	C	Seeded From UniProt	complete
enables	GO:0004362	glutathione-disulfide reductase activity	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10412 MGI:MGI:95804 PANTHER:PTN002448883 PomBase:SPBC17A3.07 RGD:621747 SGD:S000006012 WB:WBGene00008117 dictyBase:DDB_G0272754	F	Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004362	P	Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004362	P	Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004362	P	Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004362	P	Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004362	P	Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004362	P	Seeded From UniProt	complete
enables	GO:0004362	glutathione-disulfide reductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006322	F	Seeded From UniProt	complete
involved_in	GO:0006749	glutathione metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006322	P	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016156 InterPro:IPR023753	F	Seeded From UniProt	complete
involved_in	GO:0045454	cell redox homeostasis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004099	P	Seeded From UniProt	complete
enables	GO:0050660	flavin adenine dinucleotide binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006322 InterPro:IPR016156	F	Seeded From UniProt	complete
enables	GO:0050661	NADP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006322	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004099 InterPro:IPR006322 InterPro:IPR016156 InterPro:IPR023753	P	Seeded From UniProt	complete
enables	GO:0004362	glutathione-disulfide reductase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.8.1.7	F	Seeded From UniProt	complete
enables	GO:0004362	glutathione-disulfide reductase activity	PMID:11874473^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-RNO-2408514	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Adem, S & Ciftci, M (2012) Purification of rat kidney glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glutathione reductase enzymes using 2',5'-ADP Sepharose 4B affinity in a single chromatography step. Protein Expr. Purif. 81 1-4 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Carlberg, I & Mannervik, B (1975) Purification and characterization of the flavoenzyme glutathione reductase from rat liver. J. Biol. Chem. 250 5475-80 PubMed GONUTS page
↑ Jahan, S et al. (2014) Protective effects of different antioxidants against cadmium induced oxidative damage in rat testis and prostate tissues. Syst Biol Reprod Med 60 199-205 PubMed GONUTS page
↑ Dong, X et al. (2014) MiR-214 promotes the alcohol-induced oxidative stress via down-regulation of glutathione reductase and cytochrome P450 oxidoreductase in liver cells. Alcohol. Clin. Exp. Res. 38 68-77 PubMed GONUTS page
↑ Das, S et al. (2012) Nicotine induced pro-oxidant and antioxidant imbalance in rat lymphocytes: in vivo dose and time dependent approaches. Toxicol. Mech. Methods 22 711-20 PubMed GONUTS page
↑ Ponce, IT et al. (2012) Daily oscillation of glutathione redox cycle is dampened in the nutritional vitamin A deficiency. Biol Rhythm Res 43 351-372 PubMed GONUTS page
↑ Vollert, C et al. (2011) Exercise prevents sleep deprivation-associated anxiety-like behavior in rats: potential role of oxidative stress mechanisms. Behav. Brain Res. 224 233-40 PubMed GONUTS page
↑ Budak, H et al. (2014) Impact of long term Fe³⁺ toxicity on expression of glutathione system in rat liver. Environ. Toxicol. Pharmacol. 37 365-70 PubMed GONUTS page
↑ Santa Maria, C & Machado, A () Effects of development and ageing on pulmonary NADPH-cytochrome c reductase, glutathione peroxidase, glutathione reductase and thioredoxin reductase activities in male and female rats. Mech. Ageing Dev. 37 183-95 PubMed GONUTS page
↑ ^10.0 ^10.1 Kaneko, T et al. (2002) The expression of glutathione reductase in the male reproductive system of rats supports the enzymatic basis of glutathione function in spermatogenesis. Eur. J. Biochem. 269 1570-8 PubMed GONUTS page
↑ Salim, S et al. (2011) Potential contribution of oxidative stress and inflammation to anxiety and hypertension. Brain Res. 1404 63-71 PubMed GONUTS page
↑ Taniguchi, M et al. (1986) Similarities between rat liver mitochondrial and cytosolic glutathione reductases and their apoenzyme accumulation in riboflavin deficiency. Biochem. Int. 13 447-54 PubMed GONUTS page
↑ Panchenko, LF et al. (1983) [Effect of clofibrate on intracellular enzyme distribution in the rat liver]. Tsitologiia 25 1302-8 PubMed GONUTS page
↑ Nakanishi, K et al. (1997) Ischemic and reperfusion injury of cyanotic myocardium in chronic hypoxic rat model: changes in cyanotic myocardial antioxidant system. J. Thorac. Cardiovasc. Surg. 114 1088-96 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21930213-1] 1.0 ^1.1 Adem, S & Ciftci, M (2012) Purification of rat kidney glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glutathione reductase enzymes using 2',5'-ADP Sepharose 4B affinity in a single chromatography step. Protein Expr. Purif. 81 1-4 PubMed GONUTS page

[PMID:237922-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Carlberg, I & Mannervik, B (1975) Purification and characterization of the flavoenzyme glutathione reductase from rat liver. J. Biol. Chem. 250 5475-80 PubMed GONUTS page

[PMID:24758558-3] Jahan, S et al. (2014) Protective effects of different antioxidants against cadmium induced oxidative damage in rat testis and prostate tissues. Syst Biol Reprod Med 60 199-205 PubMed GONUTS page

[PMID:23905773-4] Dong, X et al. (2014) MiR-214 promotes the alcohol-induced oxidative stress via down-regulation of glutathione reductase and cytochrome P450 oxidoreductase in liver cells. Alcohol. Clin. Exp. Res. 38 68-77 PubMed GONUTS page

[PMID:22894698-5] Das, S et al. (2012) Nicotine induced pro-oxidant and antioxidant imbalance in rat lymphocytes: in vivo dose and time dependent approaches. Toxicol. Mech. Methods 22 711-20 PubMed GONUTS page

[PMID:22984325-6] Ponce, IT et al. (2012) Daily oscillation of glutathione redox cycle is dampened in the nutritional vitamin A deficiency. Biol Rhythm Res 43 351-372 PubMed GONUTS page

[PMID:21621560-7] Vollert, C et al. (2011) Exercise prevents sleep deprivation-associated anxiety-like behavior in rats: potential role of oxidative stress mechanisms. Behav. Brain Res. 224 233-40 PubMed GONUTS page

[PMID:24388910-8] Budak, H et al. (2014) Impact of long term Fe³⁺ toxicity on expression of glutathione system in rat liver. Environ. Toxicol. Pharmacol. 37 365-70 PubMed GONUTS page

[PMID:3106727-9] Santa Maria, C & Machado, A () Effects of development and ageing on pulmonary NADPH-cytochrome c reductase, glutathione peroxidase, glutathione reductase and thioredoxin reductase activities in male and female rats. Mech. Ageing Dev. 37 183-95 PubMed GONUTS page

[PMID:11874473-10] 10.0 ^10.1 Kaneko, T et al. (2002) The expression of glutathione reductase in the male reproductive system of rats supports the enzymatic basis of glutathione function in spermatogenesis. Eur. J. Biochem. 269 1570-8 PubMed GONUTS page

[PMID:21704983-11] Salim, S et al. (2011) Potential contribution of oxidative stress and inflammation to anxiety and hypertension. Brain Res. 1404 63-71 PubMed GONUTS page

[PMID:3790139-12] Taniguchi, M et al. (1986) Similarities between rat liver mitochondrial and cytosolic glutathione reductases and their apoenzyme accumulation in riboflavin deficiency. Biochem. Int. 13 447-54 PubMed GONUTS page

[PMID:6659071-13] Panchenko, LF et al. (1983) [Effect of clofibrate on intracellular enzyme distribution in the rat liver]. Tsitologiia 25 1302-8 PubMed GONUTS page

[PMID:9434704-14] Nakanishi, K et al. (1997) Ischemic and reperfusion injury of cyanotic myocardium in chronic hypoxic rat model: changes in cyanotic myocardial antioxidant system. J. Thorac. Cardiovasc. Surg. 114 1088-96 PubMed GONUTS page

[PMID:21873635-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:GSHR

Contents

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