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RAT:GLCNE
Contents
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Gne (synonyms: Glcne) | |
| Protein Name(s) | Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
UDP-GlcNAc-2-epimerase/ManAc kinase UDP-N-acetylglucosamine 2-epimerase (hydrolyzing) UDP-GlcNAc-2-epimerase Uridine diphosphate-N-acetylglucosamine-2-epimerase N-acetylmannosamine kinase ManAc kinase | |
| External Links | ||
| UniProt | O35826 | |
| EMBL | Y07744 BC062011 | |
| RefSeq | NP_446217.1 XP_006238070.1 XP_006238071.1 | |
| UniGene | Rn.18753 | |
| ProteinModelPortal | O35826 | |
| BioGrid | 250408 | |
| IntAct | O35826 | |
| MINT | MINT-4051080 | |
| STRING | 10116.ENSRNOP00000056968 | |
| PhosphoSite | O35826 | |
| PaxDb | O35826 | |
| PRIDE | O35826 | |
| Ensembl | ENSRNOT00000019532 | |
| GeneID | 114711 | |
| KEGG | rno:114711 | |
| UCSC | RGD:69239 | |
| CTD | 10020 | |
| RGD | 69239 | |
| eggNOG | COG0381 | |
| GeneTree | ENSGT00390000017246 | |
| HOGENOM | HOG000008254 | |
| HOVERGEN | HBG051733 | |
| InParanoid | O35826 | |
| KO | K12409 | |
| OMA | IAMCEDH | |
| OrthoDB | EOG73V6JN | |
| PhylomeDB | O35826 | |
| BioCyc | MetaCyc:MONOMER-14506 | |
| Reactome | REACT_213723 | |
| SABIO-RK | O35826 | |
| UniPathway | UPA00630 | |
| NextBio | 618845 | |
| PRO | PR:O35826 | |
| Proteomes | UP000002494 | |
| Genevestigator | O35826 | |
| GO | GO:0005829 GO:0005524 GO:0004553 GO:0046872 GO:0009384 GO:0008761 GO:0046835 GO:0006045 GO:0046380 GO:0006047 | |
| InterPro | IPR001312 IPR000600 IPR020004 IPR003331 | |
| Pfam | PF02350 PF00480 | |
| PRINTS | PR00475 | |
| TIGRFAMs | TIGR03568 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0009384 |
N-acylmannosamine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008761 |
UDP-N-acetylglucosamine 2-epimerase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046835 |
carbohydrate phosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0009384 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046835 |
carbohydrate phosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0009384 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004553 |
hydrolase activity, hydrolyzing O-glycosyl compounds |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006047 |
UDP-N-acetylglucosamine metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0009384 |
N-acylmannosamine kinase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046380 |
N-acetylneuraminate biosynthetic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008152 |
metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006045 |
N-acetylglucosamine biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00630 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Stäsche, R et al. (1997) A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Molecular cloning and functional expression of UDP-N-acetyl-glucosamine 2-epimerase/N-acetylmannosamine kinase. J. Biol. Chem. 272 24319-24 PubMed GONUTS page
- ↑ Blume, A et al. (2004) Domain-specific characteristics of the bifunctional key enzyme of sialic acid biosynthesis, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase. Biochem. J. 384 599-607 PubMed GONUTS page
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