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RAT:FINC
Contents
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Fn1 | |
| Protein Name(s) | Fibronectin
FN Anastellin | |
| External Links | ||
| UniProt | P04937 | |
| EMBL | X15906 L29191 L00191 L29191 L00191 L29191 L00191 M11750 X05831 X05832 X05833 X05834 | |
| PIR | S14428 | |
| UniGene | Rn.1604 | |
| ProteinModelPortal | P04937 | |
| SMR | P04937 | |
| IntAct | P04937 | |
| MINT | MINT-5024668 | |
| PhosphoSite | P04937 | |
| PaxDb | P04937 | |
| PRIDE | P04937 | |
| UCSC | RGD:2624 | |
| RGD | 2624 | |
| eggNOG | NOG12793 | |
| HOGENOM | HOG000234344 | |
| HOVERGEN | HBG005731 | |
| InParanoid | P04937 | |
| PhylomeDB | P04937 | |
| PRO | PR:P04937 | |
| Proteomes | UP000002494 | |
| Genevestigator | P04937 | |
| GO | GO:0005604 GO:0005615 GO:0005578 GO:0005201 GO:0008201 GO:0045340 GO:0002020 GO:0006953 GO:0001525 GO:0001775 GO:0007160 GO:0071773 GO:0071333 GO:0071347 GO:0071222 GO:0071288 GO:0036120 GO:0071380 GO:0071560 GO:0035924 GO:0030198 GO:0008347 GO:0043066 GO:0001503 GO:0030335 GO:0050921 GO:0008360 GO:0051384 GO:0002931 GO:0010193 GO:0009611 | |
| Gene3D | 2.10.10.10 2.60.40.10 | |
| InterPro | IPR000083 IPR003961 IPR000562 IPR013783 IPR013806 | |
| Pfam | PF00039 PF00040 PF00041 | |
| SMART | SM00058 SM00059 SM00060 | |
| SUPFAM | SSF49265 SSF57440 | |
| PROSITE | PS00022 PS01253 PS51091 PS00023 PS51092 PS50853 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0002020 |
protease binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
RGD:621316 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0002020 |
protease binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
RGD:620196 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001775 |
cell activation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1904646 |
cellular response to amyloid-beta |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1904385 |
cellular response to angiotensin |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071773 |
cellular response to BMP stimulus |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071560 |
cellular response to transforming growth factor beta stimulus |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071380 |
cellular response to prostaglandin E stimulus |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071347 |
cellular response to interleukin-1 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071333 |
cellular response to glucose stimulus |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071288 |
cellular response to mercury ion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071222 |
cellular response to lipopolysaccharide |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051384 |
response to glucocorticoid |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050921 |
positive regulation of chemotaxis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0045340 |
mercury ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042493 |
response to drug |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0036120 |
cellular response to platelet-derived growth factor stimulus |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035924 |
cellular response to vascular endothelial growth factor stimulus |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030335 |
positive regulation of cell migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030198 |
extracellular matrix organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0014823 |
response to activity |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010193 |
response to ozone |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010039 |
response to iron ion |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009611 |
response to wounding |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008347 |
glial cell migration |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007160 |
cell-matrix adhesion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005604 |
basement membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002931 |
response to ischemia |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0002020 |
protease binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
RGD:621320 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001503 |
ossification |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031012 |
extracellular matrix |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005201 |
extracellular matrix structural constituent |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008201 |
heparin binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006953 |
acute-phase response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001525 |
angiogenesis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008360 |
regulation of cell shape |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Hsu, CC & Lai, SC (2007) Matrix metalloproteinase-2, -9 and -13 are involved in fibronectin degradation of rat lung granulomatous fibrosis caused by Angiostrongylus cantonensis. Int J Exp Pathol 88 437-43 PubMed GONUTS page
- ↑ Jarnagin, WR et al. (1994) Expression of variant fibronectins in wound healing: cellular source and biological activity of the EIIIA segment in rat hepatic fibrogenesis. J. Cell Biol. 127 2037-48 PubMed GONUTS page
- ↑ Moreno-Flores, MT et al. (2001) Fibronectin modulation by A beta amyloid peptide (25-35) in cultured astrocytes of newborn rat cortex. Neurosci. Lett. 314 87-91 PubMed GONUTS page
- ↑ Pan, Z et al. (2011) Scutellarin alleviates interstitial fibrosis and cardiac dysfunction of infarct rats by inhibiting TGFβ1 expression and activation of p38-MAPK and ERK1/2. Br. J. Pharmacol. 162 688-700 PubMed GONUTS page
- ↑ Tang, CH et al. (2003) Enhancement of fibronectin synthesis and fibrillogenesis by BMP-4 in cultured rat osteoblast. J. Bone Miner. Res. 18 502-11 PubMed GONUTS page
- ↑ Jiang, T et al. (2006) Aldose reductase regulates TGF-beta1-induced production of fibronectin and type IV collagen in cultured rat mesangial cells. Nephrology (Carlton) 11 105-12 PubMed GONUTS page
- ↑ 7.0 7.1 Tang, CH et al. (2005) Prostaglandin E2 stimulates fibronectin expression through EP1 receptor, phospholipase C, protein kinase Calpha, and c-Src pathway in primary cultured rat osteoblasts. J. Biol. Chem. 280 22907-16 PubMed GONUTS page
- ↑ Fernández, L & Mosquera, JA () Interleukin-1 increases fibronectin production by cultured rat cardiac fibroblasts. Pathobiology 70 191-6 PubMed GONUTS page
- ↑ Xie, X et al. (2012) Polydatin ameliorates experimental diabetes-induced fibronectin through inhibiting the activation of NF-κB signaling pathway in rat glomerular mesangial cells. Mol. Cell. Endocrinol. 362 183-93 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 Saball, E et al. (2001) Potential mechanism of fibronectin deposits in acute renal failure induced by mercuric chloride. Mol. Cell. Biochem. 226 67-75 PubMed GONUTS page
- ↑ Jia, JB et al. (1998) Effect of endotoxin on fibronectin synthesis of rat primary cultured hepatocytes. World J. Gastroenterol. 4 329-331 PubMed GONUTS page
- ↑ Arai, H et al. (2005) Dexamethasone-induced prenatal alveolar wall thinning is associated with a decrease in EIIIA+ fibronectin isoform in the fetal rat lung. Biol. Neonate 87 113-20 PubMed GONUTS page
- ↑ Shiota, S et al. (2001) A 10-kda fragment of fibronectin type III domain is a neutrophil chemoattractant purified from conditioned medium of rat granulation tissue. Biol. Pharm. Bull. 24 835-7 PubMed GONUTS page
- ↑ Wu, D et al. (2005) Knockdown of fibronectin induces mitochondria-dependent apoptosis in rat mesangial cells. J. Am. Soc. Nephrol. 16 646-57 PubMed GONUTS page
- ↑ 15.0 15.1 Gay-Jordi, G et al. (2013) Losartan prevents heart fibrosis induced by long-term intensive exercise in an animal model. PLoS ONE 8 e55427 PubMed GONUTS page
- ↑ Kim, MS et al. (2004) Rapamycin inhibits platelet-derived growth factor-induced collagen, but not fibronectin, synthesis in rat mesangial cells. Yonsei Med. J. 45 1121-6 PubMed GONUTS page
- ↑ Wu, T et al. (2013) A potential role for caveolin-1 in VEGF-induced fibronectin upregulation in mesangial cells: involvement of VEGFR2 and Src. Am. J. Physiol. Renal Physiol. 304 F820-30 PubMed GONUTS page
- ↑ Ayaki, M et al. (2000) Cooperation of fibronectin with lysophosphatidic acid induces motility and transcellular migration of rat ascites hepatoma cells. Biochim. Biophys. Acta 1495 40-50 PubMed GONUTS page
- ↑ 19.0 19.1 Sottile, J & Hocking, DC (2002) Fibronectin polymerization regulates the composition and stability of extracellular matrix fibrils and cell-matrix adhesions. Mol. Biol. Cell 13 3546-59 PubMed GONUTS page
- ↑ Gupta, SK et al. (1998) Enhancement of fibronectin expression in rat lung by ozone and an inflammatory stimulus. Am. J. Physiol. 275 L330-5 PubMed GONUTS page
- ↑ Carlson, ES et al. (2008) Iron deficiency alters expression of genes implicated in Alzheimer disease pathogenesis. Brain Res. 1237 75-83 PubMed GONUTS page
- ↑ Havrlikova, K et al. (2004) Expression of fibronectin isoforms bearing the alternatively spliced EIIIA, EIIIB, and V segments in corneal alkali burn and keratectomy wound models in the rat. Cornea 23 812-8 PubMed GONUTS page
- ↑ Wang, XL et al. (2009) Fibronectin and focal adhesion kinase small interfering RNA modulate rat retinal Müller cells adhesion and migration. Cell. Mol. Neurobiol. 29 549-56 PubMed GONUTS page
- ↑ Zuk, A et al. (2001) Expression of fibronectin splice variants in the postischemic rat kidney. Am. J. Physiol. Renal Physiol. 280 F1037-53 PubMed GONUTS page
- ↑ Akkoyunlu, G et al. (2003) Distribution patterns of TGF-alpha, laminin and fibronectin and their relationship with folliculogenesis in rat ovary. Acta Histochem. 105 295-301 PubMed GONUTS page
- ↑ Petrini, G et al. (2002) Fibronectin expression in proximal tubules from ischemic rat kidneys without reperfusion. Mol. Cell. Biochem. 241 21-7 PubMed GONUTS page
- ↑ Yoneda, A et al. (2007) Fibronectin matrix assembly requires distinct contributions from Rho kinases I and -II. Mol. Biol. Cell 18 66-75 PubMed GONUTS page
c
- GO:0007160 ! cell-matrix adhesion
- GO:0035924 ! cellular response to vascular endothelial growth factor stimulus
- GO:0071222 ! cellular response to lipopolysaccharide
- GO:0071288 ! cellular response to mercury ion
- GO:0071333 ! cellular response to glucose stimulus
- GO:0071347 ! cellular response to interleukin-1
- GO:0071380 ! cellular response to prostaglandin E stimulus
- GO:0071560 ! cellular response to transforming growth factor beta stimulus
- GO:0071773 ! cellular response to BMP stimulus
- GO:1904385 ! cellular response to angiotensin
- GO:1904646 ! cellular response to amyloid-beta
- GO:0036120 ! cellular response to platelet-derived growth factor stimulus
- GO:0001775 ! cell activation
- GO:0007155 ! cell adhesion
- Chordata
- Craniata
e
p
r
- Rattus
- Rattus norvegicus
- GO:0008360 ! regulation of cell shape
- GO:0002931 ! response to ischemia
- GO:0009611 ! response to wounding
- GO:0010039 ! response to iron ion
- GO:0010193 ! response to ozone
- GO:0014823 ! response to activity
- GO:0042493 ! response to drug
- GO:0051384 ! response to glucocorticoid
- Rodentia
