RAT:D3ZZQ0

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	No Information Provided. (synonyms: RGD1561817_predicted (ECO:0000313 with EMBL:EDM01134.1))
Protein Name(s)	Protein Tnik (ECO:0000313 with Ensembl:ENSRNOP00000016799) Similar to Traf2 and NCK interacting kinase, splice variant 4 (Predicted), isoform CRA_a (ECO:0000313 with EMBL:EDM01134.1)
External Links
UniProt	D3ZZQ0
EMBL	AABR06015504 AABR06015505 AABR06015506 AABR06015507 AABR06015508 AABR06015509 AABR06015510 AABR06015511 AABR06015512 AABR06015513 AABR06015514 AABR06015515 AABR06015516 AABR06015517 AABR06015518 AABR06015519 AABR06015520 CH473961
RefSeq	NP_001099892.1
UniGene	Rn.220700
IntAct	D3ZZQ0
Ensembl	ENSRNOT00000016799
GeneID	294917
KEGG	rno:294917
UCSC	RGD:1561817
CTD	23043
RGD	1561817
GeneTree	ENSGT00760000118848
KO	K08840
OMA	TEQYNVG
OrthoDB	EOG73803V
PhylomeDB	D3ZZQ0
TreeFam	TF105138
NextBio	638707
Proteomes	UP000002494
GO	GO:0005737 GO:0005856 GO:0070062 GO:0005634 GO:0005524 GO:0004674 GO:0005083 GO:0031532 GO:0007256 GO:0046777 GO:0048814
InterPro	IPR001180 IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00780 PF00069
SMART	SM00036 SM00220
SUPFAM	SSF56112
PROSITE	PS50219 PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0050775	positive regulation of dendrite morphogenesis	PMID:21048137^[1]	ECO:0000315			P		In Figure 2 The effects of MINK and TNIK knockdown on neuronal morphology were visualized by co-transfected DsRed. Both MINK-RNAi and TNIK-RNAi significantly reduced arbor complexity relative to control neurons	complete CACAO 6392
involved_in	GO:0050775	positive regulation of dendrite morphogenesis	PMID:21048137^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0099092	postsynaptic density, intracellular component	PMID:20838393^[2]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0099092	postsynaptic density, intracellular component	PMID:20838393^[2]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0099092	postsynaptic density, intracellular component	PMID:20838393^[2]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:20838393^[2]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:20838393^[2]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:20838393^[2]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098793	presynapse	PMID:20838393^[2]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098793	presynapse	PMID:20838393^[2]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0002421)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023083 FB:FBgn0025743 FB:FBgn0031030 FB:FBgn0035001 FB:FBgn0261456 FB:FBgn0267698 MGI:MGI:1344404 MGI:MGI:1346882 MGI:MGI:1349394 MGI:MGI:1355329 MGI:MGI:1858416 MGI:MGI:1917378 MGI:MGI:1920334 PANTHER:PTN000684825 PomBase:SPBC1604.14c PomBase:SPBC21.06c RGD:3250 RGD:3251 RGD:621643 RGD:708455 RGD:727905 SGD:S000005242 TAIR:locus:2035989 TAIR:locus:2045658 TAIR:locus:2080394 TAIR:locus:2116417 TAIR:locus:2133559 TAIR:locus:2174969 TAIR:locus:2205523 TAIR:locus:2206885 UniProtKB:A0A0B4KGS4 UniProtKB:C0H4N8 UniProtKB:O75914 UniProtKB:O94804 UniProtKB:O95747 UniProtKB:O95819 UniProtKB:O96013 UniProtKB:Q02750 UniProtKB:Q12851 UniProtKB:Q13043 UniProtKB:Q13153 UniProtKB:Q13177 UniProtKB:Q13188 UniProtKB:Q13233 UniProtKB:Q8IVH8 UniProtKB:Q8N4C8 UniProtKB:Q92918 UniProtKB:Q99558 UniProtKB:Q9H2G2 UniProtKB:Q9H2K8 UniProtKB:Q9UEW8 UniProtKB:Q9UKE5 UniProtKB:Q9UL54 UniProtKB:Q9Y4K4 UniProtKB:Q9Y6E0 WB:WBGene00013355 WB:WBGene00017472 dictyBase:DDB_G0276459 dictyBase:DDB_G0286359	F		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000198103 PANTHER:PTN000685430	P		Seeded From UniProt	complete
involved_in	GO:0048812	neuron projection morphogenesis	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000685430 WB:WBGene00003247	P		Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919399 PANTHER:PTN000684825 RGD:727905 UniProtKB:Q7RTN6 UniProtKB:Q9C0K7	P		Seeded From UniProt	complete
involved_in	GO:0031098	stress-activated protein kinase signaling cascade	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000684825 UniProtKB:A0A1D8PKE2 UniProtKB:A0A1D8PM87	P		Seeded From UniProt	complete
involved_in	GO:0023014	signal transduction by protein phosphorylation	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000684825 TAIR:locus:2205523 UniProtKB:Q9UEW8	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023083 FB:FBgn0025743 FB:FBgn0267698 MGI:MGI:1339975 MGI:MGI:1344404 MGI:MGI:1346867 MGI:MGI:1346875 MGI:MGI:1891638 MGI:MGI:1928487 MGI:MGI:1929004 PANTHER:PTN000684825 PomBase:SPAC1F3.02c PomBase:SPBC17F3.02 PomBase:SPBC1D7.05 PomBase:SPBC409.07c PomBase:SPBC543.07 RGD:3780 RGD:620966 RGD:621643 SGD:S000000999 SGD:S000002318 SGD:S000002931 SGD:S000003664 SGD:S000004354 SGD:S000005757 SGD:S000006061 TAIR:locus:2017662 TAIR:locus:2074835 TAIR:locus:2087130 TAIR:locus:2170578 UniProtKB:A0A0B4KGS4 UniProtKB:O00506 UniProtKB:O95819 UniProtKB:Q13043 UniProtKB:Q13153 UniProtKB:Q13177 UniProtKB:Q13188 UniProtKB:Q57Y61 UniProtKB:Q7RTN6 UniProtKB:Q8N4C8 UniProtKB:Q96PY6 UniProtKB:Q9C0K7 UniProtKB:Q9H2G2 UniProtKB:Q9P289 UniProtKB:Q9S7U9 UniProtKB:Q9UKE5 UniProtKB:Q9Y4K4 UniProtKB:Q9Y6E0 UniProtKB:Q9Y6R4 WB:WBGene00002177 WB:WBGene00002201 WB:WBGene00003368 WB:WBGene00013355 dictyBase:DDB_G0284181 dictyBase:DDB_G0286359	C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Hussain, NK et al. (2010) MINK and TNIK differentially act on Rap2-mediated signal transduction to regulate neuronal structure and AMPA receptor function. J. Neurosci. 30 14786-94 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Wang, Q et al. (2011) The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function. Mol. Psychiatry 16 1006-23 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21048137-1] 1.0 ^1.1 Hussain, NK et al. (2010) MINK and TNIK differentially act on Rap2-mediated signal transduction to regulate neuronal structure and AMPA receptor function. J. Neurosci. 30 14786-94 PubMed GONUTS page

[PMID:20838393-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Wang, Q et al. (2011) The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function. Mol. Psychiatry 16 1006-23 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:D3ZZQ0

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