RAT:AT2A1

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Atp2a1
Protein Name(s)	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 SERCA1 SR Ca(2+)-ATPase 1 Calcium pump 1 Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform Endoplasmic reticulum class 1/2 Ca(2+) ATPase
External Links
UniProt	Q64578
EMBL	M99223 AF091853 AF091852
PIR	A48849
RefSeq	NP_478120.1
UniGene	Rn.217139
ProteinModelPortal	Q64578
SMR	Q64578
PhosphoSite	Q64578
PRIDE	Q64578
GeneID	116601
KEGG	rno:116601
CTD	487
RGD	621293
HOVERGEN	HBG105648
InParanoid	Q64578
KO	K05853
PhylomeDB	Q64578
NextBio	619311
PRO	PR:Q64578
Proteomes	UP000002494
Genevestigator	Q64578
GO	GO:0005783 GO:0005789 GO:0005793 GO:0031673 GO:0031674 GO:0016021 GO:0043231 GO:0016020 GO:0048471 GO:0016529 GO:0033017 GO:0005524 GO:0005509 GO:0005388 GO:0005338 GO:0006200 GO:0070588 GO:0006816 GO:1901264 GO:0045988 GO:1901679 GO:0031448 GO:0006937 GO:0006942 GO:0043434 GO:0070296
Gene3D	1.20.1110.10 2.70.150.10 3.40.1110.10
InterPro	IPR006068 IPR004014 IPR023299 IPR018303 IPR023298 IPR008250 IPR023214 IPR005782 IPR001757 IPR030332
PANTHER	PTHR24093:SF215
Pfam	PF00689 PF00690 PF00122 PF00702
PRINTS	PR00119 PR00120
SMART	SM00831
SUPFAM	SSF56784 SSF81660
TIGRFAMs	TIGR01116 TIGR01494
PROSITE	PS00154

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0033017	sarcoplasmic reticulum membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04191	C	Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8R429	C	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04191-2	C	Seeded From UniProt	complete
involved_in	GO:0045988	negative regulation of striated muscle contraction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14983-2	P	Seeded From UniProt	complete
involved_in	GO:0043434	response to peptide hormone	PMID:9295312^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0031674	I band	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14983-2	C	Seeded From UniProt	complete
part_of	GO:0031673	H zone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14983-2	C	Seeded From UniProt	complete
involved_in	GO:0031448	positive regulation of fast-twitch skeletal muscle fiber contraction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14983	P	Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04191-2	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04191-2	C	Seeded From UniProt	complete
involved_in	GO:0006942	regulation of striated muscle contraction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14983-2	P	Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14983	P	Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04191-2	F	Seeded From UniProt	complete
part_of	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04191-2	C	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14983-2	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04191-2	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04191-2	F	Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14983	F	Seeded From UniProt	complete
enables	GO:0005388	calcium-transporting ATPase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14983	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04191	C	Seeded From UniProt	complete
involved_in	GO:1990036	calcium ion import into sarcoplasmic reticulum	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04191	P	Seeded From UniProt	complete
involved_in	GO:0070296	sarcoplasmic reticulum calcium ion transport	PMID:19029185^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	PMID:14506614^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	PMID:8447366^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	PMID:19029185^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	PMID:12409282^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	PMID:12222829^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:12409282^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:19029185^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:12409282^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005388	calcium-transporting ATPase activity	PMID:12409282^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005388	calcium-transporting ATPase activity	PMID:12222829^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005338	nucleotide-sugar transmembrane transporter activity	PMID:12409282^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000643382 RGD:2174 UniProtKB:P16615	P	Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105058 PANTHER:PTN000643383	C	Seeded From UniProt	complete
enables	GO:0008553	proton-exporting ATPase activity, phosphorylative mechanism	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001943383 PomBase:SPAC1071.10c PomBase:SPCC1020.01c SGD:S000002976 SGD:S000005957 TAIR:locus:2020372 TAIR:locus:2044450 TAIR:locus:2165600 UniProtKB:A0A1D8PJ01	F	Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0263006 MGI:MGI:88110 PANTHER:PTN000643382 UniProtKB:P16615 WB:WBGene00004736 ZFIN:ZDB-GENE-020905-1	P	Seeded From UniProt	complete
enables	GO:0005388	calcium-transporting ATPase activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88110 PANTHER:PTN000643382 RGD:2174 RGD:621293 TAIR:locus:2201916 UniProtKB:O14983 UniProtKB:P16615 WB:WBGene00004736	F	Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	PMID:9887021^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005388	calcium-transporting ATPase activity	PMID:9887021^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0015931	nucleobase-containing compound transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005338	P	Seeded From UniProt	complete
involved_in	GO:0099132	ATP hydrolysis coupled cation transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005388	P	Seeded From UniProt	complete
involved_in	GO:0099132	ATP hydrolysis coupled cation transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005388	P	Seeded From UniProt	complete
involved_in	GO:0099132	ATP hydrolysis coupled cation transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005388	P	Seeded From UniProt	complete
involved_in	GO:0099132	ATP hydrolysis coupled cation transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005388	P	Seeded From UniProt	complete
involved_in	GO:0099132	ATP hydrolysis coupled cation transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005388	P	Seeded From UniProt	complete
involved_in	GO:0099132	ATP hydrolysis coupled cation transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005388	P	Seeded From UniProt	complete
involved_in	GO:1901264	carbohydrate derivative transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005338	P	Seeded From UniProt	complete
involved_in	GO:1902600	proton transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008553	P	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR023299	F	Seeded From UniProt	complete
enables	GO:0005388	calcium-transporting ATPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005782 InterPro:IPR030332	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030332	F	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030332	C	Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005782	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001757 InterPro:IPR005782 InterPro:IPR030332	C	Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030332	C	Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030332	P	Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	PMID:12222829^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006937	regulation of muscle contraction	PMID:12403631^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0109	P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C	Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0703	C	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0241	C	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Algenstaedt, P et al. (1997) Insulin receptor substrate proteins create a link between the tyrosine phosphorylation cascade and the Ca2+-ATPases in muscle and heart. J. Biol. Chem. 272 23696-702 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Murphy, RM et al. (2009) Calsequestrin content and SERCA determine normal and maximal Ca2+ storage levels in sarcoplasmic reticulum of fast- and slow-twitch fibres of rat. J. Physiol. (Lond.) 587 443-60 PubMed GONUTS page
↑ Ohlendieck, K et al. (2003) Ca2+-regulatory muscle proteins in the alcohol-fed rat. Metab. Clin. Exp. 52 1102-12 PubMed GONUTS page
↑ Wu, KD & Lytton, J (1993) Molecular cloning and quantification of sarcoplasmic reticulum Ca(2+)-ATPase isoforms in rat muscles. Am. J. Physiol. 264 C333-41 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Schertzer, JD et al. (2003) Mechanisms underlying increases in SR Ca2+-ATPase activity after exercise in rat skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 284 E597-610 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Matsunaga, S et al. (2001) Inactivation of sarcoplasmic reticulum Ca(2+)-atpase in low-frequency stimulated rat muscle. J. Muscle Res. Cell. Motil. 22 685-91 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^8.0 ^8.1 Ji, Y et al. (1999) SERCA1a can functionally substitute for SERCA2a in the heart. Am. J. Physiol. 276 H89-97 PubMed GONUTS page
↑ Ferrington, DA et al. (2002) Comparable levels of Ca-ATPase inhibition by phospholamban in slow-twitch skeletal and cardiac sarcoplasmic reticulum. Biochemistry 41 13289-96 PubMed GONUTS page

[PMID:9295312-1] Algenstaedt, P et al. (1997) Insulin receptor substrate proteins create a link between the tyrosine phosphorylation cascade and the Ca2+-ATPases in muscle and heart. J. Biol. Chem. 272 23696-702 PubMed GONUTS page

[PMID:19029185-2] 2.0 ^2.1 ^2.2 Murphy, RM et al. (2009) Calsequestrin content and SERCA determine normal and maximal Ca2+ storage levels in sarcoplasmic reticulum of fast- and slow-twitch fibres of rat. J. Physiol. (Lond.) 587 443-60 PubMed GONUTS page

[PMID:14506614-3] Ohlendieck, K et al. (2003) Ca2+-regulatory muscle proteins in the alcohol-fed rat. Metab. Clin. Exp. 52 1102-12 PubMed GONUTS page

[PMID:8447366-4] Wu, KD & Lytton, J (1993) Molecular cloning and quantification of sarcoplasmic reticulum Ca(2+)-ATPase isoforms in rat muscles. Am. J. Physiol. 264 C333-41 PubMed GONUTS page

[PMID:12409282-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Schertzer, JD et al. (2003) Mechanisms underlying increases in SR Ca2+-ATPase activity after exercise in rat skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 284 E597-610 PubMed GONUTS page

[PMID:12222829-6] 6.0 ^6.1 ^6.2 Matsunaga, S et al. (2001) Inactivation of sarcoplasmic reticulum Ca(2+)-atpase in low-frequency stimulated rat muscle. J. Muscle Res. Cell. Motil. 22 685-91 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9887021-8] 8.0 ^8.1 Ji, Y et al. (1999) SERCA1a can functionally substitute for SERCA2a in the heart. Am. J. Physiol. 276 H89-97 PubMed GONUTS page

[PMID:12403631-9] Ferrington, DA et al. (2002) Comparable levels of Ca-ATPase inhibition by phospholamban in slow-twitch skeletal and cardiac sarcoplasmic reticulum. Biochemistry 41 13289-96 PubMed GONUTS page

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RAT:AT2A1

Contents

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References

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