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RAT:AOFA

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Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Maoa
Protein Name(s) Amine oxidase [flavin-containing] A

Monoamine oxidase type A MAO-A

External Links
UniProt P21396
EMBL D00688
S45812
PIR JT0528
UniGene Rn.224544
PDB 1O5W
PDBsum 1O5W
ProteinModelPortal P21396
SMR P21396
BindingDB P21396
ChEMBL CHEMBL2095196
PhosphoSite P21396
PaxDb P21396
PRIDE P21396
UCSC RGD:61898
RGD 61898
eggNOG COG1231
HOGENOM HOG000221615
HOVERGEN HBG004255
InParanoid P21396
PhylomeDB P21396
BioCyc MetaCyc:MONOMER-14994
BRENDA 1.4.3.4
SABIO-RK P21396
EvolutionaryTrace P21396
PRO PR:P21396
Proteomes UP000002494
Genevestigator P21396
GO GO:0016021
GO:0005741
GO:0050660
GO:0008131
GO:0051378
GO:0042424
GO:0042135
GO:0042443
GO:0042428
Gene3D 3.40.50.720
InterPro IPR002937
IPR001613
IPR016040
Pfam PF01593
PRINTS PR00757

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0051378

serotonin binding

PMID:11754741[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0051378

serotonin binding

PMID:11754741[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0051378

serotonin binding

PMID:11263670[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0050660

flavin adenine dinucleotide binding

PMID:11754741[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0050660

flavin adenine dinucleotide binding

PMID:11754741[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0042443

phenylethylamine metabolic process

PMID:11754741[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042443

phenylethylamine metabolic process

PMID:11754741[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042428

serotonin metabolic process

PMID:11754741[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042428

serotonin metabolic process

PMID:11754741[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042428

serotonin metabolic process

PMID:11263670[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042424

catecholamine catabolic process

PMID:12388421[3]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008131

primary amine oxidase activity

PMID:11754741[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008131

primary amine oxidase activity

PMID:12388421[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008131

primary amine oxidase activity

PMID:11754741[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008131

primary amine oxidase activity

PMID:11263670[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

PMID:11263670[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001613
InterPro:IPR002937

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001613
InterPro:IPR002937

P

Seeded From UniProt

complete

involved_in

GO:0042135

neurotransmitter catabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0531

P

Seeded From UniProt

complete

involved_in

GO:0006584

catecholamine metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0128

P

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1000
UniProtKB-SubCell:SL-0172

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Ma, J & Ito, A (2002) Tyrosine residues near the FAD binding site are critical for FAD binding and for the maintenance of the stable and active conformation of rat monoamine oxidase A. J. Biochem. 131 107-11 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Heron, P et al. (2001) Paradoxical effects of copper and manganese on brain mitochondrial function. Life Sci. 68 1575-83 PubMed GONUTS page
  3. 3.0 3.1 Pizzinat, N et al. (2003) Substrate-dependent regulation of MAO-A in rat mesangial cells: involvement of dopamine D2-like receptors. Am. J. Physiol. Renal Physiol. 284 F167-74 PubMed GONUTS page