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RAT:ALDOA
Contents
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Aldoa | |
| Protein Name(s) | Fructose-bisphosphate aldolase A
Muscle-type aldolase | |
| External Links | ||
| UniProt | P05065 | |
| EMBL | M12919 M14420 X04261 X04262 X04263 X04264 BC064440 M28282 | |
| PIR | A24532 | |
| RefSeq | NP_001170776.1 NP_001258465.1 NP_036627.1 XP_006230273.1 | |
| UniGene | Rn.1774 | |
| ProteinModelPortal | P05065 | |
| SMR | P05065 | |
| BioGrid | 246379 | |
| IntAct | P05065 | |
| MINT | MINT-4567674 | |
| STRING | 10116.ENSRNOP00000031940 | |
| PhosphoSite | P05065 | |
| World-2DPAGE | 0004:P05065 | |
| PaxDb | P05065 | |
| PRIDE | P05065 | |
| Ensembl | ENSRNOT00000032362 | |
| GeneID | 24189 | |
| KEGG | rno:24189 | |
| UCSC | RGD:2089 | |
| CTD | 226 | |
| RGD | 2089 | |
| eggNOG | COG3588 | |
| GeneTree | ENSGT00390000010235 | |
| HOGENOM | HOG000220876 | |
| HOVERGEN | HBG002386 | |
| InParanoid | P05065 | |
| KO | K01623 | |
| OMA | PNMVIDG | |
| OrthoDB | EOG744T94 | |
| PhylomeDB | P05065 | |
| Reactome | REACT_217998 REACT_225694 | |
| SABIO-RK | P05065 | |
| UniPathway | UPA00109 | |
| NextBio | 602559 | |
| PRO | PR:P05065 | |
| Proteomes | UP000002494 | |
| Genevestigator | P05065 | |
| GO | GO:0005737 GO:0031674 GO:0031430 GO:0005739 GO:0004332 GO:0006096 GO:0051289 GO:0043627 GO:0009408 GO:0001666 GO:0032496 GO:0035094 | |
| Gene3D | 3.20.20.70 | |
| InterPro | IPR029768 IPR013785 IPR029769 IPR000741 | |
| PANTHER | PTHR11627 | |
| Pfam | PF00274 | |
| PROSITE | PS00158 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0004332 |
fructose-bisphosphate aldolase activity |
ECO:0000314 |
F |
Figure 2A shows that rat cell lines that are transfected with Aldolase A siRNA have lower aldolase activity. The activity assay is described in reference 17, in which they use fructose bisphosphate as the substrate. This shows fructose bisphosphate aldolase activity. |
complete | |||||
|
part_of |
GO:0005720 |
nuclear heterochromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0004222) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0004222) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051289 |
protein homotetramerization |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006096 |
glycolytic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004332 |
fructose-bisphosphate aldolase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043627 |
response to estrogen |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035094 |
response to nicotine |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032496 |
response to lipopolysaccharide |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019242 |
methylglyoxal biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009408 |
response to heat |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003674 |
molecular_function |
ECO:0000307 |
no biological data found used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001666 |
response to hypoxia |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004332 |
fructose-bisphosphate aldolase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006096 |
glycolytic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004332 |
fructose-bisphosphate aldolase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016829 |
lyase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006096 |
glycolytic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0324 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031430 |
M band |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031674 |
I band |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Ritterson Lew, C & Tolan, DR (2012) Targeting of several glycolytic enzymes using RNA interference reveals aldolase affects cancer cell proliferation through a non-glycolytic mechanism. J. Biol. Chem. 287 42554-63 PubMed GONUTS page
- ↑ 2.0 2.1 Mamczur, P & Dzugaj, A (2008) Aldolase A is present in smooth muscle cell nuclei. Acta Biochim. Pol. 55 799-805 PubMed GONUTS page
- ↑ Blake, CA et al. (2005) Estrogen regulation of the rat anterior pituitary gland proteome. Exp. Biol. Med. (Maywood) 230 800-7 PubMed GONUTS page
- ↑ Hwang, YY & Li, MD (2006) Proteins differentially expressed in response to nicotine in five rat brain regions: identification using a 2-DE/MS-based proteomics approach. Proteomics 6 3138-53 PubMed GONUTS page
- ↑ 5.0 5.1 Scharte, M et al. (2006) LPS increases hepatic HIF-1alpha protein and expression of the HIF-1-dependent gene aldolase A in rats. J. Surg. Res. 135 262-7 PubMed GONUTS page
- ↑ Liu, J et al. (2011) Upregulation of aldolase B and overproduction of methylglyoxal in vascular tissues from rats with metabolic syndrome. Cardiovasc. Res. 92 494-503 PubMed GONUTS page
- ↑ Tacchini, L et al. (1999) Differential activation of some transcription factors during rat liver ischemia, reperfusion, and heat shock. J. Cell. Physiol. 180 255-62 PubMed GONUTS page
- ↑ Dukes, AA et al. (2008) Changes in endoplasmic reticulum stress proteins and aldolase A in cells exposed to dopamine. J. Neurochem. 106 333-46 PubMed GONUTS page
- ↑ Hatzfeld, A et al. (1978) Location of adult and fetal aldolases A, B, and C by immunoperoxidase technique in LF fast-growing rat hepatomas. Cancer Res. 38 16-22 PubMed GONUTS page
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