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RAT:ALDH2
Contents
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Aldh2 | |
| Protein Name(s) | Aldehyde dehydrogenase, mitochondrial
ALDH class 2 ALDH-E2 ALDH1 | |
| External Links | ||
| UniProt | P11884 | |
| EMBL | X14977 BC062081 M19030 AY566467 AY566468 AY566469 AF529165 AY034137 | |
| PIR | S03564 | |
| RefSeq | NP_115792.1 | |
| UniGene | Rn.101781 | |
| PDB | 1OM2 2V1S 2V1T 3AWR 3AX2 3AX3 3AX5 | |
| PDBsum | 1OM2 2V1S 2V1T 3AWR 3AX2 3AX3 3AX5 | |
| ProteinModelPortal | P11884 | |
| SMR | P11884 | |
| IntAct | P11884 | |
| MINT | MINT-4569918 | |
| BindingDB | P11884 | |
| ChEMBL | CHEMBL2812 | |
| GuidetoPHARMACOLOGY | 2595 | |
| PhosphoSite | P11884 | |
| World-2DPAGE | 0004:P11884 | |
| PaxDb | P11884 | |
| PRIDE | P11884 | |
| GeneID | 29539 | |
| KEGG | rno:29539 | |
| UCSC | RGD:69219 | |
| CTD | 217 | |
| RGD | 69219 | |
| eggNOG | COG1012 | |
| HOGENOM | HOG000271505 | |
| HOVERGEN | HBG000097 | |
| InParanoid | P11884 | |
| KO | K00128 | |
| PhylomeDB | P11884 | |
| SABIO-RK | P11884 | |
| UniPathway | UPA00780 | |
| EvolutionaryTrace | P11884 | |
| NextBio | 609531 | |
| Proteomes | UP000002494 | |
| Genevestigator | P11884 | |
| GO | GO:0005759 GO:0005739 GO:0004029 GO:0042802 GO:0070404 GO:0071398 GO:0032870 GO:0006068 GO:0001889 GO:0043066 GO:0032355 GO:0055093 GO:0032496 GO:0035094 GO:0032570 GO:0033574 | |
| Gene3D | 3.40.309.10 3.40.605.10 | |
| InterPro | IPR016161 IPR016163 IPR016160 IPR029510 IPR016162 IPR015590 | |
| Pfam | PF00171 | |
| SUPFAM | SSF53720 | |
| PROSITE | PS00070 PS00687 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0004029 |
aldehyde dehydrogenase (NAD) activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071398 |
cellular response to fatty acid |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0070404 |
NADH binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055093 |
response to hyperoxia |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035094 |
response to nicotine |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0004029 |
aldehyde dehydrogenase (NAD) activity |
ECO:0000315 |
F |
Figure 2 shows that ALDH2 activity increases in the presence of AldA-1 |
complete | |||||
|
involved_in |
GO:0033574 |
response to testosterone |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032870 |
cellular response to hormone stimulus |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032570 |
response to progesterone |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032496 |
response to lipopolysaccharide |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032355 |
response to estradiol |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004029 |
aldehyde dehydrogenase (NAD) activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001889 |
liver development |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004029 |
aldehyde dehydrogenase (NAD) activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0012036 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR015590 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016620 |
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR015590 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0043878 |
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004029 |
aldehyde dehydrogenase (NAD) activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006068 |
ethanol catabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00780 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Chen, CH et al. (2008) Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Science 321 1493-5 PubMed GONUTS page
- ↑ Canuto, RA et al. (2001) Increase in class 2 aldehyde dehydrogenase expression by arachidonic acid in rat hepatoma cells. Biochem. J. 357 811-8 PubMed GONUTS page
- ↑ Gonnella, TP et al. (2011) NADH fluorescence lifetime analysis of the effect of magnesium ions on ALDH2. Chem. Biol. Interact. 191 147-52 PubMed GONUTS page
- ↑ Xu, D et al. (2006) Mitochondrial aldehyde dehydrogenase attenuates hyperoxia-induced cell death through activation of ERK/MAPK and PI3K-Akt pathways in lung epithelial cells. Am. J. Physiol. Lung Cell Mol. Physiol. 291 L966-75 PubMed GONUTS page
- ↑ Zhang, P et al. (2011) Inhibition of aldehyde dehydrogenase 2 activity enhances antimycin-induced rat cardiomyocytes apoptosis through activation of MAPK signaling pathway. Biomed. Pharmacother. 65 590-3 PubMed GONUTS page
- ↑ 6.0 6.1 Jeng, JJ & Weiner, H (1991) Purification and characterization of catalytically active precursor of rat liver mitochondrial aldehyde dehydrogenase expressed in Escherichia coli. Arch. Biochem. Biophys. 289 214-22 PubMed GONUTS page
- ↑ Hu, D et al. (2002) Altered profile of gene expression in rat hearts induced by chronic nicotine consumption. Biochem. Biophys. Res. Commun. 297 729-36 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Crabb, DW et al. (1995) Hormonal and chemical influences on the expression of class 2 aldehyde dehydrogenases in rat H4IIEC3 and human HuH7 hepatoma cells. Alcohol. Clin. Exp. Res. 19 1414-9 PubMed GONUTS page
- ↑ Pang, Y et al. (2001) Analysis of genes differentially expressed in astrocytes stimulated with lipopolysaccharide using cDNA arrays. Brain Res. 914 15-22 PubMed GONUTS page
- ↑ Blake, CA et al. (2005) Estrogen regulation of the rat anterior pituitary gland proteome. Exp. Biol. Med. (Maywood) 230 800-7 PubMed GONUTS page
- ↑ Tottmar, SO et al. (1973) The subcellular distribution and properties of aldehyde dehydrogenases in rat liver. Biochem. J. 135 577-86 PubMed GONUTS page
- ↑ Yoon, M et al. (2006) Developmental expression of aldehyde dehydrogenase in rat: a comparison of liver and lung development. Toxicol. Sci. 89 386-98 PubMed GONUTS page
- ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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