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RAT:AHI1

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Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Ahi1
Protein Name(s) Jouberin

Abelson helper integration site 1 protein homolog AHI-1

External Links
UniProt Q6DTM3
EMBL AY647140
RefSeq NP_001002277.1
UniGene Rn.155144
ProteinModelPortal Q6DTM3
STRING 10116.ENSRNOP00000019077
PaxDb Q6DTM3
PRIDE Q6DTM3
GeneID 308923
KEGG rno:308923
CTD 54806
RGD 1303040
eggNOG COG2319
HOGENOM HOG000033864
HOVERGEN HBG080824
InParanoid Q6DTM3
KO K16740
PhylomeDB Q6DTM3
NextBio 659816
PRO PR:Q6DTM3
Proteomes UP000002494
Genevestigator Q6DTM3
GO GO:0005912
GO:0005911
GO:0005814
GO:0005813
GO:0036064
GO:0005929
GO:0031513
GO:0072372
GO:0036038
GO:0034613
GO:0007417
GO:0042384
GO:0060271
GO:0035844
GO:0001947
GO:0030902
GO:0070121
GO:0070986
GO:0001738
GO:0043066
GO:0071599
GO:0035845
GO:0030862
GO:0002092
GO:0045944
GO:0039023
GO:0039008
GO:0050795
GO:0010842
GO:0065001
GO:0007169
GO:0016192
Gene3D 2.130.10.10
InterPro IPR001452
IPR015943
IPR001680
IPR017986
Pfam PF00018
PF00400
PRINTS PR00452
SMART SM00326
SM00320
SUPFAM SSF50044
SSF50978
PROSITE PS50002
PS50082
PS50294

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0001934

positive regulation of protein phosphorylation

PMID:18636121[1]

ECO:0000314

P

Suppressing Hap1 expression by siRNA also reduced the level of phosphorylated Erk and Akt (Figure 7C). Quantification of the ratio of phosphorylated Erk or Akt to the total amount of Erk and Akt confirmed the decreased phosphorylation of these proteins (Figure 7D).

complete

part_of

GO:0005929

cilium

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8N157

C

Seeded From UniProt

complete

involved_in

GO:0071599

otic vesicle development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3E5

P

Seeded From UniProt

complete

involved_in

GO:0070986

left/right axis specification

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07DM1

P

Seeded From UniProt

complete

involved_in

GO:0070121

Kupffer's vesicle development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07DM1

P

Seeded From UniProt

complete

involved_in

GO:0065001

specification of axis polarity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3E5

P

Seeded From UniProt

complete

involved_in

GO:0060271

cilium assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3E5

P

Seeded From UniProt

complete

involved_in

GO:0050795

regulation of behavior

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3E5

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3E5

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3E5

P

Seeded From UniProt

complete

involved_in

GO:0039023

pronephric duct morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07DM1

P

Seeded From UniProt

complete

involved_in

GO:0039008

pronephric nephron tubule morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3E5

P

Seeded From UniProt

complete

part_of

GO:0036064

ciliary basal body

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3E5

C

Seeded From UniProt

complete

part_of

GO:0036038

MKS complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3E5

C

Seeded From UniProt

complete

involved_in

GO:0035845

photoreceptor cell outer segment organization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3E5

P

Seeded From UniProt

complete

involved_in

GO:0035844

cloaca development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3E5

P

Seeded From UniProt

complete

involved_in

GO:0034613

cellular protein localization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3E5

P

Seeded From UniProt

complete

part_of

GO:0097730

non-motile cilium

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3E5

C

Seeded From UniProt

complete

involved_in

GO:0030902

hindbrain development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3E5

P

Seeded From UniProt

complete

involved_in

GO:0030862

positive regulation of polarized epithelial cell differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3E5

P

Seeded From UniProt

complete

involved_in

GO:0016192

vesicle-mediated transport

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3E5

P

Seeded From UniProt

complete

involved_in

GO:0010842

retina layer formation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3E5

P

Seeded From UniProt

complete

involved_in

GO:0007417

central nervous system development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3E5

P

Seeded From UniProt

complete

involved_in

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3E5

P

Seeded From UniProt

complete

part_of

GO:0005929

cilium

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3E5

C

Seeded From UniProt

complete

part_of

GO:0005912

adherens junction

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8N157

C

Seeded From UniProt

complete

part_of

GO:0005911

cell-cell junction

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8N157

C

Seeded From UniProt

complete

part_of

GO:0005814

centriole

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3E5

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8N157

C

Seeded From UniProt

complete

involved_in

GO:0002092

positive regulation of receptor internalization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3E5

P

Seeded From UniProt

complete

involved_in

GO:0001947

heart looping

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3E5

P

Seeded From UniProt

complete

involved_in

GO:0001738

morphogenesis of a polarized epithelium

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8K3E5

P

Seeded From UniProt

complete

involved_in

GO:1990403

embryonic brain development

PMID:19819228[2]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046325

negative regulation of glucose import

PMID:20045148[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032094

response to food

PMID:19819228[2]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0021510

spinal cord development

PMID:19819228[2]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:23658157[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

part_of

GO:0005929

cilium

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0969

C

Seeded From UniProt

complete

involved_in

GO:0030030

cell projection organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0970

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

part_of

GO:0042995

cell projection

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0966

C

Seeded From UniProt

complete

part_of

GO:0030054

cell junction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0965

C

Seeded From UniProt

complete

part_of

GO:0005814

centriole

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0046

C

Seeded From UniProt

complete

part_of

GO:0005912

adherens junction

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0009

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Sheng, G et al. (2008) Huntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in mice. J. Clin. Invest. 118 2785-95 PubMed GONUTS page
  2. 2.0 2.1 2.2 Han, SB et al. (2009) Regulation of AHI1 expression in adult rat brain: Implication in hypothalamic feeding control. Biochem. Biophys. Res. Commun. 390 535-40 PubMed GONUTS page
  3. Prior, MJ et al. (2010) The characterization of Abelson helper integration site-1 in skeletal muscle and its links to the metabolic syndrome. Metab. Clin. Exp. 59 1057-64 PubMed GONUTS page
  4. Weng, L et al. (2013) Loss of Ahi1 affects early development by impairing BM88/Cend1-mediated neuronal differentiation. J. Neurosci. 33 8172-84 PubMed GONUTS page