RAT:ABCG8

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Abcg8
Protein Name(s)	ATP-binding cassette sub-family G member 8 Sterolin-2
External Links
UniProt	P58428
EMBL	AF351785 AY145899 AF404109
RefSeq	NP_569098.2
UniGene	Rn.161892
ProteinModelPortal	P58428
PRIDE	P58428
Ensembl	ENSRNOT00000007638 ENSRNOT00000061871
GeneID	155192
KEGG	rno:155192
UCSC	RGD:620300
CTD	64241
RGD	620300
GeneTree	ENSGT00740000114855
HOVERGEN	HBG050444
InParanoid	P58428
KO	K05684
OMA	FTYSGQP
OrthoDB	EOG70W3CV
PhylomeDB	P58428
Reactome	REACT_197252 REACT_258713
NextBio	620895
PRO	PR:P58428
Proteomes	UP000002494
Genevestigator	P58428
GO	GO:0016324 GO:0043190 GO:0005524 GO:0016887 GO:0017127 GO:0015248 GO:0033344 GO:0042632 GO:0030301 GO:0007588 GO:0045796 GO:0010949 GO:0015914 GO:0030300 GO:0042493 GO:0007584 GO:0015918
Gene3D	3.40.50.300
InterPro	IPR003593 IPR013525 IPR003439 IPR017871 IPR027417
Pfam	PF01061 PF00005
SMART	SM00382
SUPFAM	SSF52540
PROSITE	PS00211 PS50893

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0043190	ATP-binding cassette (ABC) transporter complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9H221	C	Seeded From UniProt	complete
enables	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9H221	F	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9DBM0	C	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9DBM0	C	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9DBM0	F	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:17109865^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007584	response to nutrient	PMID:15710224^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003996 FB:FBgn0020762 PANTHER:PTN000443108 TAIR:locus:2084081	P	Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1914720 PANTHER:PTN002710463 UniProtKB:Q9H221	P	Seeded From UniProt	complete
enables	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0020762 PANTHER:PTN000443108 TAIR:locus:2016089 UniProtKB:Q9H221 UniProtKB:Q9H222	F	Seeded From UniProt	complete
contributes_to	GO:0017127	cholesterol transporter activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1914720 PANTHER:PTN002710463 UniProtKB:Q9H221	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000443108 PomBase:SPCC18B5.01c RGD:631345 SGD:S000002418 SGD:S000005537 SGD:S000005679 SGD:S000005855 SGD:S000005979 TAIR:locus:2009680 TAIR:locus:2016089 TAIR:locus:2019693 TAIR:locus:2028656 TAIR:locus:2030898 TAIR:locus:2037703 TAIR:locus:2039523 TAIR:locus:2039682 TAIR:locus:2044893 TAIR:locus:2046203 TAIR:locus:2049867 TAIR:locus:2084081 TAIR:locus:2090009 TAIR:locus:2100514 TAIR:locus:2124029 TAIR:locus:2144133 TAIR:locus:2196593 UniProtKB:A0A1D8PCM6 UniProtKB:A0A1D8PE84 UniProtKB:A0A1D8PQ95 UniProtKB:E9RBG1 UniProtKB:Q4X006 UniProtKB:Q8H8V7 UniProtKB:Q94A18 UniProtKB:Q9UNQ0	C	Seeded From UniProt	complete
involved_in	GO:0055092	sterol homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9DBM0 ensembl:ENSMUSP00000035246	P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9DBM0 ensembl:ENSMUSP00000035246	F	Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9DBM0 ensembl:ENSMUSP00000035246	C	Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9DBM0 ensembl:ENSMUSP00000035246	P	Seeded From UniProt	complete
involved_in	GO:0033344	cholesterol efflux	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9DBM0 ensembl:ENSMUSP00000035246	P	Seeded From UniProt	complete
enables	GO:0017127	cholesterol transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9DBM0 ensembl:ENSMUSP00000035246	F	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9DBM0 ensembl:ENSMUSP00000035246	C	Seeded From UniProt	complete
involved_in	GO:0015918	sterol transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9DBM0 ensembl:ENSMUSP00000035246	P	Seeded From UniProt	complete
involved_in	GO:0015914	phospholipid transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9DBM0 ensembl:ENSMUSP00000035246	P	Seeded From UniProt	complete
involved_in	GO:0007588	excretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9DBM0 ensembl:ENSMUSP00000035246	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9DBM0 ensembl:ENSMUSP00000035246	C	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H221 ensembl:ENSP00000496450	C	Seeded From UniProt	complete
involved_in	GO:0010949	negative regulation of intestinal phytosterol absorption	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H221 ensembl:ENSP00000496450	P	Seeded From UniProt	complete
involved_in	GO:0007588	excretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H221 ensembl:ENSP00000496450	P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H221 ensembl:ENSP00000496450	F	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H221 ensembl:ENSP00000496450	F	Seeded From UniProt	complete
involved_in	GO:0045796	negative regulation of intestinal cholesterol absorption	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H221 ensembl:ENSP00000496450	P	Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H221 ensembl:ENSP00000496450	C	Seeded From UniProt	complete
part_of	GO:0043190	ATP-binding cassette (ABC) transporter complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H221 ensembl:ENSP00000496450	C	Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H221 ensembl:ENSP00000496450	P	Seeded From UniProt	complete
enables	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H221 ensembl:ENSP00000496450	F	Seeded From UniProt	complete
involved_in	GO:0033344	cholesterol efflux	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H221 ensembl:ENSP00000496450	P	Seeded From UniProt	complete
enables	GO:0017127	cholesterol transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H221 ensembl:ENSP00000496450	F	Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H221 ensembl:ENSP00000496450	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003439 InterPro:IPR017871	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013525	C	Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003439 InterPro:IPR017871	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
involved_in	GO:0006869	lipid transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0445	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0015	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Lally, S et al. (2007) The different effect of pioglitazone as compared to insulin on expression of hepatic and intestinal genes regulating post-prandial lipoproteins in diabetes. Atherosclerosis 193 343-51 PubMed GONUTS page
↑ Hoekstra, M et al. (2005) Diet induced regulation of genes involved in cholesterol metabolism in rat liver parenchymal and Kupffer cells. J. Hepatol. 42 400-7 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17109865-1] Lally, S et al. (2007) The different effect of pioglitazone as compared to insulin on expression of hepatic and intestinal genes regulating post-prandial lipoproteins in diabetes. Atherosclerosis 193 343-51 PubMed GONUTS page

[PMID:15710224-2] Hoekstra, M et al. (2005) Diet induced regulation of genes involved in cholesterol metabolism in rat liver parenchymal and Kupffer cells. J. Hepatol. 42 400-7 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:ABCG8

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References

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