RALSO:FABH

Species (Taxon ID)	Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum). (267608)
Gene Name(s)	fabH (ECO:0000255 with HAMAP-Rule:MF_01815)
Protein Name(s)	3-oxoacyl-[acyl-carrier-protein] synthase 3 (ECO:0000255 with HAMAP-Rule:MF_01815) 3-oxoacyl-[acyl-carrier-protein] synthase III (ECO:0000255 with HAMAP-Rule:MF_01815) Beta-ketoacyl-ACP synthase III (ECO:0000255 with HAMAP-Rule:MF_01815) KAS III (ECO:0000255 with HAMAP-Rule:MF_01815)
External Links
UniProt	Q8Y0J4
EMBL	AL646052
RefSeq	WP_011001002.1
ProteinModelPortal	Q8Y0J4
SMR	Q8Y0J4
STRING	267608.RSc1050
EnsemblBacteria	CAD14752
GeneID	1219859
KEGG	rso:RSc1050
PATRIC	fig|267608.8.peg.1068
eggNOG	ENOG4105CCZ COG0332
HOGENOM	HOG000246674
KO	K00648
OMA	IGPTVWG
OrthoDB	POG091H02M9
UniPathway	UPA00094
Proteomes	UP000001436
GO	GO:0005737 GO:0004315 GO:0033818 GO:0006633
Gene3D	3.40.47.10
HAMAP	MF_01815
InterPro	IPR013751 IPR013747 IPR004655 IPR016039
Pfam	PF08545 PF08541
SUPFAM	SSF53901
TIGRFAMs	TIGR00747

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0033818	beta-ketoacyl-acyl-carrier-protein synthase III activity	PMID:26305336	ECO:0000315			F		Ralstonia solanacearum with RsfabH KO was unable to grow on media lacking Octanoic acid, while it was able to grow on the media where it was included. Growth on octanoic was rescued when the fabH gene was put back. Specifically, beta-ketoacyl-acyl-carrier protein synthase III activity was observed, as seen in figure 2A and 2B.	complete CACAO 12938
	GO:0044579	butyryl-CoA biosynthetic process from acetyl-CoA	PMID:26305336	ECO:0000315			P		Addition of EcFabH or RsFabH to the reaction mixture led to formation of butyryl-ACP (S1B fig, lane 1 and lane 2). Upon addition of the long chain E. coli 3-ketoacyl-ACP synthase I, FabB, to the reactions, all reactions produced long chain acyl-ACP species (S1B fig, lane 3 and lane 4). This data supports the notion that like E. coli FabH, RsFabH could complete the initial cycle of fatty acid synthesis to produce butyryl-ACP. Organism: Ralstonia solanacearum	complete CACAO 12955
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016039	F		Seeded From UniProt	complete
enables	GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004655 InterPro:IPR013751	F		Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004655 InterPro:IPR013751	P		Seeded From UniProt	complete
enables	GO:0033818	beta-ketoacyl-acyl-carrier-protein synthase III activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.3.1.180	F		Seeded From UniProt	complete
enables	GO:0033818	beta-ketoacyl-acyl-carrier-protein synthase III activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000085060	F		Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000085060	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000085060	C		Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	P		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	F		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0276	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0016746	transferase activity, transferring acyl groups	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0012	F		Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	GO_REF:0000037 GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0275 UniPathway:UPA00094	P		Seeded From UniProt	complete
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