RABIT:AOXA

Species (Taxon ID)	Oryctolagus cuniculus (Rabbit). (9986)
Gene Name(s)	AOX1 (ECO:0000250 with UniProtKB:Q06278) (synonyms: AO)
Protein Name(s)	Aldehyde oxidase 1 (ECO:0000250 with UniProtKB:Q06278) Azaheterocycle hydroxylase 1 (ECO:0000305 with PMID:9224775^[1]) Retinal oxidase (ECO:0000303 with PMID:8305467^[2]) Retinoic acid synthase (ECO:0000303 with PMID:8305467^[2])
External Links
UniProt	P80456
EMBL	AB009345
RefSeq	NP_001075459.1
SMR	P80456
STRING	9986.ENSOCUP00000012025
BindingDB	P80456
ChEMBL	CHEMBL1641356
PRIDE	P80456
GeneID	100008601
KEGG	ocu:100008601
CTD	316
eggNOG	KOG0430 COG4630 COG4631
HOGENOM	HOG000191197
InParanoid	P80456
KO	K00157
OrthoDB	48717at2759
BRENDA	1.2.3.1
SABIO-RK	P80456
PRO	PR:P80456
Proteomes	UP000001811
GO	GO:0005829 GO:0051537 GO:0004031 GO:0009055 GO:0071949 GO:0050660 GO:0102797 GO:0102798 GO:0005506 GO:0043546 GO:0051287 GO:0042803 GO:0050250 GO:0017144 GO:0055114
InterPro	IPR002888 IPR036884 IPR036010 IPR001041 IPR006058 IPR000674 IPR036856 IPR016208 IPR014313 IPR008274 IPR037165 IPR005107 IPR036683 IPR016166 IPR036318 IPR002346 IPR022407
Pfam	PF01315 PF02738 PF03450 PF00941 PF00111 PF01799
PIRSF	PIRSF000127
SMART	SM01008 SM01092
SUPFAM	SSF47741 SSF54292 SSF54665 SSF55447 SSF56003 SSF56176
TIGRFAMs	TIGR02969
PROSITE	PS00197 PS51085 PS51387 PS00559

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes
enables	GO:0050250	retinal oxidase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O54754	F	Seeded From UniProt
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06278	F	Seeded From UniProt
part_of	GO:0005829	cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06278	C	Seeded From UniProt
enables	GO:0051537	2 iron, 2 sulfur cluster binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06278	F	Seeded From UniProt
enables	GO:0050660	flavin adenine dinucleotide binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06278	F	Seeded From UniProt
enables	GO:0043546	molybdopterin cofactor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06278	F	Seeded From UniProt
enables	GO:0005506	iron ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06278	F	Seeded From UniProt
enables	GO:0004031	aldehyde oxidase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06278	F	Seeded From UniProt
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06278	P	Seeded From UniProt
involved_in	GO:0017144	drug metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06278	P	Seeded From UniProt
involved_in	GO:0022900	electron transport chain	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0009055	P	Seeded From UniProt
enables	GO:0005506	iron ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016208	F	Seeded From UniProt
enables	GO:0009055	electron transfer activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001041 InterPro:IPR036010	F	Seeded From UniProt
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002346 InterPro:IPR002888 InterPro:IPR008274 InterPro:IPR014313 InterPro:IPR016208 InterPro:IPR037165	F	Seeded From UniProt
enables	GO:0043546	molybdopterin cofactor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR022407	F	Seeded From UniProt
enables	GO:0046872	metal ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002888 InterPro:IPR014313	F	Seeded From UniProt
enables	GO:0050660	flavin adenine dinucleotide binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR036318	F	Seeded From UniProt
enables	GO:0051287	NAD binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014313	F	Seeded From UniProt
enables	GO:0051536	iron-sulfur cluster binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001041 InterPro:IPR036010	F	Seeded From UniProt
enables	GO:0051537	2 iron, 2 sulfur cluster binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006058	F	Seeded From UniProt
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002346 InterPro:IPR002888 InterPro:IPR008274 InterPro:IPR014313 InterPro:IPR016208 InterPro:IPR022407 InterPro:IPR037165	P	Seeded From UniProt
enables	GO:0071949	FAD binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016166	F	Seeded From UniProt
enables	GO:0004031	aldehyde oxidase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.2.3.1	F	Seeded From UniProt
enables	GO:0102798	heptaldehyde:oxygen oxidoreductase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.2.3.1	F	Seeded From UniProt
enables	GO:0102797	geranial:oxygen oxidoreductase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.2.3.1	F	Seeded From UniProt
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P	Seeded From UniProt
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt
enables	GO:0051537	2 iron, 2 sulfur cluster binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0001	F	Seeded From UniProt
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F	Seeded From UniProt
enables	GO:0051536	iron-sulfur cluster binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0411	F	Seeded From UniProt
enables	GO:0050250	retinal oxidase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O54754	F	Seeded From UniProt
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06278	F	Seeded From UniProt
part_of	GO:0005829	cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06278	C	Seeded From UniProt
enables	GO:0051537	2 iron, 2 sulfur cluster binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06278	F	Seeded From UniProt
enables	GO:0050660	flavin adenine dinucleotide binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06278	F	Seeded From UniProt
enables	GO:0043546	molybdopterin cofactor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06278	F	Seeded From UniProt
enables	GO:0005506	iron ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06278	F	Seeded From UniProt
enables	GO:0004031	aldehyde oxidase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06278	F	Seeded From UniProt
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06278	P	Seeded From UniProt
involved_in	GO:0017144	drug metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06278	P	Seeded From UniProt
involved_in	GO:0022900	electron transport chain	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0009055	P	Seeded From UniProt
enables	GO:0005506	iron ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016208	F	Seeded From UniProt
enables	GO:0009055	electron transfer activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001041 InterPro:IPR036010	F	Seeded From UniProt
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002346 InterPro:IPR002888 InterPro:IPR008274 InterPro:IPR014313 InterPro:IPR016208 InterPro:IPR037165	F	Seeded From UniProt
enables	GO:0043546	molybdopterin cofactor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR022407	F	Seeded From UniProt
enables	GO:0046872	metal ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002888 InterPro:IPR014313	F	Seeded From UniProt
enables	GO:0050660	flavin adenine dinucleotide binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR036318	F	Seeded From UniProt
enables	GO:0051287	NAD binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014313	F	Seeded From UniProt
enables	GO:0051536	iron-sulfur cluster binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001041 InterPro:IPR036010	F	Seeded From UniProt
enables	GO:0051537	2 iron, 2 sulfur cluster binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006058	F	Seeded From UniProt
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002346 InterPro:IPR002888 InterPro:IPR008274 InterPro:IPR014313 InterPro:IPR016208 InterPro:IPR022407 InterPro:IPR037165	P	Seeded From UniProt
enables	GO:0071949	FAD binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016166	F	Seeded From UniProt
enables	GO:0004031	aldehyde oxidase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.2.3.1	F	Seeded From UniProt
enables	GO:0102798	heptaldehyde:oxygen oxidoreductase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.2.3.1	F	Seeded From UniProt
enables	GO:0102797	geranial:oxygen oxidoreductase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.2.3.1	F	Seeded From UniProt
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P	Seeded From UniProt
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt
enables	GO:0051537	2 iron, 2 sulfur cluster binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0001	F	Seeded From UniProt
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F	Seeded From UniProt
enables	GO:0051536	iron-sulfur cluster binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0411	F	Seeded From UniProt
part_of	GO:0005737	cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0086	C	Seeded From UniProt
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Rashidi, MR et al. (1997) In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver. Drug Metab. Dispos. 25 805-13 PubMed GONUTS page
↑ ^2.0 ^2.1 Tsujita, M et al. (1994) Characteristic properties of retinal oxidase (retinoic acid synthase) from rabbit hepatocytes. Biochim. Biophys. Acta 1204 108-16 PubMed GONUTS page

[PMID:9224775-1] Rashidi, MR et al. (1997) In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver. Drug Metab. Dispos. 25 805-13 PubMed GONUTS page

[PMID:8305467-2] 2.0 ^2.1 Tsujita, M et al. (1994) Characteristic properties of retinal oxidase (retinoic acid synthase) from rabbit hepatocytes. Biochim. Biophys. Acta 1204 108-16 PubMed GONUTS page

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RABIT:AOXA

Contents

Annotations

Notes

References

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