PYRHO:RTCB

Species (Taxon ID)	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 /NBRC 100139 / OT-3). (70601)
Gene Name(s)	rtcB
Protein Name(s)	tRNA-splicing ligase RtcB Pho hyp2 intein
External Links
UniProt	O59245
EMBL	BA000001
PIR	B71039
PDB	1UC2 4DWQ 4DWR 4ISJ 4ISZ 4IT0
PDBsum	1UC2 4DWQ 4DWR 4ISJ 4ISZ 4IT0
ProteinModelPortal	O59245
SMR	O59245
STRING	70601.PH1602
EnsemblBacteria	BAA30714
KEGG	pho:PH1602
eggNOG	arCOG03158 arCOG04246 COG1690
HOGENOM	HOG000296282
KO	K14415
OMA	VHNCGVR
OrthoDB	POG093Z01O0
EvolutionaryTrace	O59245
Proteomes	UP000000752
GO	GO:0003677 GO:0004519 GO:0019002 GO:0030145 GO:0003972 GO:0016539 GO:0006314 GO:0000394 GO:0008033
Gene3D	2.170.16.10 3.10.28.10
InterPro	IPR028992 IPR003586 IPR003587 IPR027434 IPR006142 IPR030934 IPR004042 IPR006141 IPR004860 IPR001233
PANTHER	PTHR11118
Pfam	PF14528 PF01139
PRINTS	PR00379
SMART	SM00305 SM00306
SUPFAM	SSF103365 SSF51294 SSF55608
TIGRFAMs	TIGR01443 TIGR01445
PROSITE	PS50818 PS50819 PS50817

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0008664	manganese ion binding	PMID:22949672	ECO:0000315			F		in figure 5(A), activity assay shows how the wild type of RtcB ligates a linear RNA to circular RNA. RtcB assayed and found to ligates the 5'-hydroxyl and 2',3'-cyclic phosphate of a 21-nt RNA. the figure also compare the wild type to three other mutant of RtcB. the three mutants did not form a circular RNA, conforming the wild type function.	complete CACAO 12637
enables	GO:0019002	GMP binding		ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0030145	manganese ion binding		ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000394	RNA splicing, via endonucleolytic cleavage and ligation		ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003972	RNA ligase (ATP) activity		ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0019002	GMP binding	PMID:22949672	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0030145	manganese ion binding	PMID:22949672	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003972	RNA ligase (ATP) activity	PMID:22949672	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000394	RNA splicing, via endonucleolytic cleavage and ligation		ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003972	RNA ligase (ATP) activity		ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004519	P		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004519	P		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004518	P		Seeded From UniProt	complete
enables	GO:0004519	endonuclease activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004042 InterPro:IPR004860	F		Seeded From UniProt	complete
involved_in	GO:0006396	RNA processing	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001233 InterPro:IPR036025	P		Seeded From UniProt	complete
enables	GO:0008452	RNA ligase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001233 InterPro:IPR036025	F		Seeded From UniProt	complete
involved_in	GO:0016539	intein-mediated protein splicing	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006141 InterPro:IPR006142	P		Seeded From UniProt	complete
involved_in	GO:0006314	intron homing	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0404	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0004518	nuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0540	F		Seeded From UniProt	complete
involved_in	GO:0008033	tRNA processing	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0819	P		Seeded From UniProt	complete
enables	GO:0004519	endonuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0255	F		Seeded From UniProt	complete
enables	GO:0016874	ligase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0436	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
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References

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