PSEAE:VFR

Species (Taxon ID)	Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228). (208964)
Gene Name(s)	vfr
Protein Name(s)	Cyclic AMP receptor-like protein
External Links
UniProt	P55222
EMBL	U16318 AE004091
PIR	A55540
RefSeq	NP_249343.1
PDB	2OZ6
PDBsum	2OZ6
ProteinModelPortal	P55222
SMR	P55222
STRING	208964.PA0652
DNASU	880744
EnsemblBacteria	AAG04041
GeneID	880744
KEGG	pae:PA0652
PATRIC	19835566
PseudoCAP	PA0652
eggNOG	COG0664
HOGENOM	HOG000250565
InParanoid	P55222
KO	K10914
OMA	RAKSACE
OrthoDB	EOG69GZGV
PhylomeDB	P55222
EvolutionaryTrace	P55222
Proteomes	UP000002438
GO	GO:0005622 GO:0030552 GO:0003677 GO:0003700 GO:0009405 GO:0043902 GO:0006351
Gene3D	1.10.10.10 2.60.120.10
InterPro	IPR018490 IPR018488 IPR000595 IPR012318 IPR014710 IPR001808 IPR018335 IPR011991
Pfam	PF00027 PF00325
PRINTS	PR00034
SMART	SM00100 SM00419
SUPFAM	SSF51206
PROSITE	PS00888 PS00889 PS50042 PS00042 PS51063

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0006351	transcription, DNA-templated	PMID:9190808^[1]	ECO:0000315			P	TABLE 3. Effect of Vfr on lasR expression in P. aeruginosa	complete CACAO 5040
involved_in	GO:0006351	transcription, DNA-templated	PMID:9190808^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:20494996^[2]	ECO:0001204	in vitro transcription assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:17159200^[3]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_002516.2	F	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:9190808^[1]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:19801409^[4]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:12218009^[5]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:20494996^[2]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_002516.2	C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:18227247^[6]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_002516.2	C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:17159200^[3]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_002516.2	C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:12218009^[5]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_002516.2	C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:9190808^[1]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:20494996^[2]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:19801409^[4]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:18227247^[6]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:12218009^[5]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0001217	DNA-binding transcription repressor activity	PMID:12218009^[5]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0001217	DNA-binding transcription repressor activity	PMID:12218009^[5]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_002516.2	F	Seeded From UniProt	complete
enables	GO:0001217	DNA-binding transcription repressor activity	PMID:12218009^[5]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0001216	DNA-binding transcription activator activity	PMID:9190808^[1]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0001216	DNA-binding transcription activator activity	PMID:19801409^[4]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0001216	DNA-binding transcription activator activity	PMID:20494996^[2]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_002516.2	F	Seeded From UniProt	complete
enables	GO:0001216	DNA-binding transcription activator activity	PMID:18227247^[6]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_002516.2	F	Seeded From UniProt	complete
enables	GO:0001216	DNA-binding transcription activator activity	PMID:9190808^[1]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0001216	DNA-binding transcription activator activity	PMID:20494996^[2]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0001216	DNA-binding transcription activator activity	PMID:19801409^[4]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0001216	DNA-binding transcription activator activity	PMID:18227247^[6]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:9190808^[1]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:19801409^[4]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:12218009^[5]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:20494996^[2]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_002516.2	F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:18227247^[6]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_002516.2	F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:12218009^[5]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_002516.2	F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:9190808^[1]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:20494996^[2]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:19801409^[4]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:18227247^[6]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:12218009^[5]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10164 EcoGene:EG10325 PANTHER:PTN000705815	C	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10325 PANTHER:PTN000705815 UniProtKB:P22260 UniProtKB:P46148 UniProtKB:P9WMH3	F	Seeded From UniProt	complete
involved_in	GO:0043902	positive regulation of multi-organism process	PMID:9190808^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009405	pathogenesis	PMID:14977975^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0001217	P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0001217	P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0001217	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012318	F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018335	F	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012318 InterPro:IPR018335	P	Seeded From UniProt	complete
involved_in	GO:0009405	pathogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0843	P	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
enables	GO:0030552	cAMP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0116	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Albus, AM et al. (1997) Vfr controls quorum sensing in Pseudomonas aeruginosa. J. Bacteriol. 179 3928-35 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Fuchs, EL et al. (2010) The Pseudomonas aeruginosa Vfr regulator controls global virulence factor expression through cyclic AMP-dependent and -independent mechanisms. J. Bacteriol. 192 3553-64 PubMed GONUTS page
↑ ^3.0 ^3.1 Kanack, KJ et al. (2006) Characterization of DNA-binding specificity and analysis of binding sites of the Pseudomonas aeruginosa global regulator, Vfr, a homologue of the Escherichia coli cAMP receptor protein. Microbiology (Reading, Engl.) 152 3485-96 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Endoh, T & Engel, JN (2009) CbpA: a polarly localized novel cyclic AMP-binding protein in Pseudomonas aeruginosa. J. Bacteriol. 191 7193-205 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 Dasgupta, N et al. (2002) fleQ, the gene encoding the major flagellar regulator of Pseudomonas aeruginosa, is sigma70 dependent and is downregulated by Vfr, a homolog of Escherichia coli cyclic AMP receptor protein. J. Bacteriol. 184 5240-50 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Ferrell, E et al. (2008) Regulation of Pseudomonas aeruginosa ptxR by Vfr. Microbiology (Reading, Engl.) 154 431-9 PubMed GONUTS page
↑ ^7.0 ^7.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Smith, RS et al. (2004) An adenylate cyclase-controlled signaling network regulates Pseudomonas aeruginosa virulence in a mouse model of acute pneumonia. Infect. Immun. 72 1677-84 PubMed GONUTS page

[PMID:9190808-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Albus, AM et al. (1997) Vfr controls quorum sensing in Pseudomonas aeruginosa. J. Bacteriol. 179 3928-35 PubMed GONUTS page

[PMID:20494996-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Fuchs, EL et al. (2010) The Pseudomonas aeruginosa Vfr regulator controls global virulence factor expression through cyclic AMP-dependent and -independent mechanisms. J. Bacteriol. 192 3553-64 PubMed GONUTS page

[PMID:17159200-3] 3.0 ^3.1 Kanack, KJ et al. (2006) Characterization of DNA-binding specificity and analysis of binding sites of the Pseudomonas aeruginosa global regulator, Vfr, a homologue of the Escherichia coli cAMP receptor protein. Microbiology (Reading, Engl.) 152 3485-96 PubMed GONUTS page

[PMID:19801409-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Endoh, T & Engel, JN (2009) CbpA: a polarly localized novel cyclic AMP-binding protein in Pseudomonas aeruginosa. J. Bacteriol. 191 7193-205 PubMed GONUTS page

[PMID:12218009-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 Dasgupta, N et al. (2002) fleQ, the gene encoding the major flagellar regulator of Pseudomonas aeruginosa, is sigma70 dependent and is downregulated by Vfr, a homolog of Escherichia coli cyclic AMP receptor protein. J. Bacteriol. 184 5240-50 PubMed GONUTS page

[PMID:18227247-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Ferrell, E et al. (2008) Regulation of Pseudomonas aeruginosa ptxR by Vfr. Microbiology (Reading, Engl.) 154 431-9 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:14977975-8] Smith, RS et al. (2004) An adenylate cyclase-controlled signaling network regulates Pseudomonas aeruginosa virulence in a mouse model of acute pneumonia. Infect. Immun. 72 1677-84 PubMed GONUTS page

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PSEAE:VFR

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