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PSEAE:PVDA
Contents
| Species (Taxon ID) | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 /JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1). (208964) | |
| Gene Name(s) | pvdA (ECO:0000303 with PMID:8106324[1]) (synonyms: pvd-1) | |
| Protein Name(s) | L-ornithine N(5)-monooxygenase (ECO:0000303 with PMID:17900176[2])
L-ornithine N(5)-hydroxylase (ECO:0000303 with PMID:17015659[3]) Ornithine hydroxylase (ECO:0000303 with PMID:17900176[2]) L-ornithine N(5)-oxygenase (ECO:0000303 with PMID:8106324[1]) Pyoverdin biosynthesis protein A (ECO:0000303 with PMID:8106324[1]) | |
| External Links | ||
| UniProt | Q51548 | |
| EMBL | Z25465 AE004091 | |
| PIR | A49892 D83346 | |
| RefSeq | NP_251076.1 WP_003114509.1 | |
| PDB | 3S5W 3S61 | |
| PDBsum | 3S5W 3S61 | |
| ProteinModelPortal | Q51548 | |
| SMR | Q51548 | |
| IntAct | Q51548 | |
| MINT | Q51548 | |
| STRING | 208964.PA2386 | |
| PaxDb | Q51548 | |
| PRIDE | Q51548 | |
| EnsemblBacteria | AAG05774 | |
| GeneID | 882167 | |
| KEGG | pae:PA2386 | |
| PATRIC | fig|208964.12.peg.2496 | |
| PseudoCAP | PA2386 | |
| eggNOG | ENOG4105F1Y COG3486 | |
| HOGENOM | HOG000237193 | |
| InParanoid | Q51548 | |
| KO | K10531 | |
| OMA | CEGTHGL | |
| PhylomeDB | Q51548 | |
| BioCyc | MetaCyc:MONOMER-15307 PAER208964:G1FZ6-2424-MONOMER | |
| BRENDA | 1.14.13.B10 | |
| UniPathway | UPA00019 | |
| Proteomes | UP000002438 | |
| GO | GO:0005737 GO:0005886 GO:0004497 GO:0034338 GO:0006879 GO:0002049 | |
| Gene3D | 3.50.50.60 | |
| InterPro | IPR036188 IPR025700 | |
| Pfam | PF13434 | |
| SUPFAM | SSF51905 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0034338 |
short-chain carboxylesterase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG11101 |
F |
Seeded From UniProt |
|||
|
involved_in |
GO:0006879 |
cellular iron ion homeostasis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001009003 |
P |
Seeded From UniProt |
|||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
||||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
||||
|
involved_in |
GO:0002049 |
pyoverdine biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
||||
|
involved_in |
GO:0002049 |
pyoverdine biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
||||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0997 |
C |
Seeded From UniProt |
|||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
||||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
||||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
||||
|
enables |
GO:0004497 |
monooxygenase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
||||
|
involved_in |
GO:0002049 |
pyoverdine biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00019 |
P |
Seeded From UniProt |
|||
|
enables |
GO:0034338 |
short-chain carboxylesterase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG11101 |
F |
Seeded From UniProt |
|||
|
involved_in |
GO:0006879 |
cellular iron ion homeostasis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001009003 |
P |
Seeded From UniProt |
|||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
||||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
||||
|
involved_in |
GO:0002049 |
pyoverdine biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
||||
|
involved_in |
GO:0002049 |
pyoverdine biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
||||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0997 |
C |
Seeded From UniProt |
|||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
||||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
||||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
||||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
||||
|
enables |
GO:0004497 |
monooxygenase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
||||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
||||
|
involved_in |
GO:0002049 |
pyoverdine biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00019 |
P |
Seeded From UniProt |
|||
| GO:0031172 |
ornithine N5-monooxygenase activity |
ECO:0005636 |
F |
Figure 1B & 1C show increased expression and production of pyoverdine in Pseudomonas aeruginosa, the final product of the biosynthetic pathway that pvdA/L-ornithine N(5)-monooxygenase is involved in, when iron levels are low, denoting upregulation of pvdA/L-ornithine N(5)-monooxygenase under iron-deficient conditions. |
complete | |||||
| GO:0002049 |
pyoverdine biosynthetic process |
ECO:0005636 |
P |
Figure 1B & 1C show increased expression and production of pyoverdine in Pseudomonas aeruginosa, the final product of the biosynthetic pathway that pvdA/L-ornithine N(5)-monooxygenase is involved in, when iron levels are low. |
complete | |||||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Visca, P et al. (1994) Cloning and nucleotide sequence of the pvdA gene encoding the pyoverdin biosynthetic enzyme L-ornithine N5-oxygenase in Pseudomonas aeruginosa. J. Bacteriol. 176 1128-40 PubMed GONUTS page
- ↑ 2.0 2.1 Meneely, KM & Lamb, AL (2007) Biochemical characterization of a flavin adenine dinucleotide-dependent monooxygenase, ornithine hydroxylase from Pseudomonas aeruginosa, suggests a novel reaction mechanism. Biochemistry 46 11930-7 PubMed GONUTS page
- ↑ Ge, L & Seah, SY (2006) Heterologous expression, purification, and characterization of an l-ornithine N(5)-hydroxylase involved in pyoverdine siderophore biosynthesis in Pseudomonas aeruginosa. J. Bacteriol. 188 7205-10 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 5.0 5.1 Guillon, L et al. (2012) High cellular organization of pyoverdine biosynthesis in Pseudomonas aeruginosa: clustering of PvdA at the old cell pole. Environ. Microbiol. 14 1982-94 PubMed GONUTS page
- ↑ 6.0 6.1 Imperi, F et al. (2008) Membrane-association determinants of the omega-amino acid monooxygenase PvdA, a pyoverdine biosynthetic enzyme from Pseudomonas aeruginosa. Microbiology (Reading, Engl.) 154 2804-13 PubMed GONUTS page
- ↑ 7.0 7.1 Vandenende, CS et al. (2004) Functional characterization of an aminotransferase required for pyoverdine siderophore biosynthesis in Pseudomonas aeruginosa PAO1. J. Bacteriol. 186 5596-602 PubMed GONUTS page
- ↑ 8.0 8.1 Mayfield, JA et al. (2010) Comprehensive spectroscopic, steady state, and transient kinetic studies of a representative siderophore-associated flavin monooxygenase. J. Biol. Chem. 285 30375-88 PubMed GONUTS page
- ↑ 9.0 9.1 Goss, CH et al. (2018) Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections. Sci Transl Med 10 PubMed GONUTS page
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