GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PSEAE:PCHA

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228). (208964)
Gene Name(s) pchA
Protein Name(s) Salicylate biosynthesis isochorismate synthase

Isochorismate mutase

External Links
UniProt Q51508
EMBL X82644
AE004091
PIR S60203
RefSeq NP_252921.1
ProteinModelPortal Q51508
SMR Q51508
STRING 208964.PA4231
EnsemblBacteria AAG07619
GeneID 881821
KEGG pae:PA4231
PATRIC 19843152
PseudoCAP PA4231
eggNOG COG1169
HOGENOM HOG000028185
InParanoid Q51508
KO K01851
OMA FGWDCAL
OrthoDB EOG63NMJJ
PhylomeDB Q51508
BioCyc MetaCyc:MONOMER-15306
UniPathway UPA00025
Proteomes UP000002438
GO GO:0008909
GO:0042864
GO:0009697
Gene3D 3.60.120.10
InterPro IPR005801
IPR015890
IPR004561
PANTHER PTHR11236:SF3
Pfam PF00425
SUPFAM SSF56322
TIGRFAMs TIGR00543

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0042864

pyochelin biosynthetic process

PMID:12624097[1]

ECO:0000314

P

Figure 4 represents in vitro study to determine rate limiting factor in Salicylate production. The figure shows that Isochorismate synthase is the rate limiting enzyme in production of Salicylate, which is an intermediate for Pyochelin biosynthesis.

complete
CACAO 7178

involved_in

GO:0042864

pyochelin biosynthetic process

PMID:12624097[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009697

salicylic acid biosynthetic process

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000132898
UniProtKB:Q51508

P

Seeded From UniProt

complete

enables

GO:0008909

isochorismate synthase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10261
PANTHER:PTN000132898
UniProtKB:Q51508

F

Seeded From UniProt

complete

involved_in

GO:0009697

salicylic acid biosynthetic process

PMID:7500944[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008909

isochorismate synthase activity

PMID:12624097[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008909

isochorismate synthase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004561

F

Seeded From UniProt

complete

involved_in

GO:0009058

biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004561
InterPro:IPR005801

P

Seeded From UniProt

complete

enables

GO:0008909

isochorismate synthase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:5.4.4.2

F

Seeded From UniProt

complete

enables

GO:0016853

isomerase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0413

F

Seeded From UniProt

complete

involved_in

GO:0009697

salicylic acid biosynthetic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00025

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Gaille, C et al. (2003) Isochorismate synthase (PchA), the first and rate-limiting enzyme in salicylate biosynthesis of Pseudomonas aeruginosa. J. Biol. Chem. 278 16893-8 PubMed GONUTS page
  2. 2.0 2.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. Serino, L et al. (1995) Structural genes for salicylate biosynthesis from chorismate in Pseudomonas aeruginosa. Mol. Gen. Genet. 249 217-28 PubMed GONUTS page