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PSEAE:FABY
Contents
| Species (Taxon ID) | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228). (208964) | |
| Gene Name(s) | fabY | |
| Protein Name(s) | Beta-ketoacyl-[acyl-carrier-protein] synthase FabY (ECO:0000303 with PMID:22753059[1])
Beta-ketoacyl-ACP synthase (ECO:0000303 with PMID:22753059[1]) KAS (ECO:0000303 with PMID:22753059[1]) Beta-ketoacyl synthase KAS I/II domain-containing enzyme (ECO:0000303 with PMID:22753059[1]) | |
| External Links | ||
| UniProt | Q9HU15 | |
| EMBL | AE004091 | |
| PIR | E82999 | |
| RefSeq | NP_253861.1 WP_003114068.1 | |
| PDB | 4CW4 | |
| PDBsum | 4CW4 | |
| ProteinModelPortal | Q9HU15 | |
| SMR | Q9HU15 | |
| DIP | DIP-61329N | |
| STRING | 208964.PA5174 | |
| PaxDb | Q9HU15 | |
| EnsemblBacteria | AAG08559 | |
| GeneID | 881783 | |
| KEGG | pae:PA5174 | |
| PATRIC | 19845191 | |
| PseudoCAP | PA5174 | |
| eggNOG | ENOG4107RX2 COG0304 | |
| InParanoid | Q9HU15 | |
| KO | K18473 | |
| OMA | ACATFLY | |
| OrthoDB | EOG64JFJC | |
| PhylomeDB | Q9HU15 | |
| BioCyc | MetaCyc:MONOMER-17580 | |
| UniPathway | UPA00094 | |
| Proteomes | UP000002438 | |
| GO | GO:0033818 GO:0006633 GO:0009245 GO:0009372 GO:0019290 | |
| Gene3D | 3.40.47.10 | |
| InterPro | IPR014031 IPR014030 IPR020841 IPR016039 | |
| Pfam | PF00109 PF02801 | |
| SMART | SM00825 | |
| SUPFAM | SSF53901 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0033818 |
beta-ketoacyl-acyl-carrier-protein synthase III activity |
ECO:0000314 |
F |
Figure 8a: NADPH consumption of PA5174 and E. coli FabH were similar |
complete | |||||
| GO:0006633 |
fatty acid biosynthetic process |
ECO:0000315 |
P |
Figure 4B: The PA5174 incapacitated mutant displayed a lower percent incorporated label than the wild type. |
complete | |||||
| GO:0009372 |
quorum sensing |
ECO:0000315 |
P |
Figure 5A: Production of acyl-homoserine lactone decreased in PA5174 incapacitated mutants and increased in PA5174 complemented mutants (TMT41) Figure 5B: Wild-type strain and TMT41 mutants produced halos indicating ion-pairing complexation between methylene blue dye, cetyltrimethylammonium bromide, and secreted rhamnolipids but mutant with nonfunctional PA5174 did not. Figure 5C: Rhamnose levels were higher in TMT41 mutant than in wild type. Rhamnose levels were also lower in mutant with nonfunctional PA5174 than in wild type. |
complete | |||||
| GO:0019290 |
siderophore biosynthetic process |
ECO:0000315 |
P |
Figure 7: Wild-type, mutant strain without PA5174, PA5174 back-complemented with plasmid, and FabH-complemented strain were streaked on LB-chrome azurol S indicator plates. Only the PA5174 deficient strain displayed no signs of iron sequestration (no yellow border around bacteria). |
complete | |||||
| GO:0009245 |
lipid A biosynthetic process |
ECO:0000315 |
P |
Figure 4: Spectra for wild-type and fabY-complemented mutant strain were similar, spectrum for fabY deficient strain was different Table 2: almost every lipid A species in fabY deficient strain was modified with L-Ara4N |
complete | |||||
|
involved_in |
GO:0009245 |
lipid A biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019290 |
siderophore biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009372 |
quorum sensing |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006633 |
fatty acid biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0033818 |
beta-ketoacyl-acyl-carrier-protein synthase III activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0033818 |
beta-ketoacyl-acyl-carrier-protein synthase III activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016746 |
transferase activity, transferring acyl groups |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006631 |
fatty acid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006633 |
fatty acid biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0275 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 Yuan, Y et al. (2012) Fatty acid biosynthesis in Pseudomonas aeruginosa is initiated by the FabY class of β-ketoacyl acyl carrier protein synthases. J. Bacteriol. 194 5171-84 PubMed GONUTS page
- ↑ 2.0 2.1 Six, DA et al. (2014) Deletion of the β-acetoacetyl synthase FabY in Pseudomonas aeruginosa induces hypoacylation of lipopolysaccharide and increases antimicrobial susceptibility. Antimicrob. Agents Chemother. 58 153-61 PubMed GONUTS page
