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PMID:9927605
| Citation |
Herman, MA, Ch'ng, Q, Hettenbach, SM, Ratliff, TM, Kenyon, C and Herman, RK (1999) EGL-27 is similar to a metastasis-associated factor and controls cell polarity and cell migration in C. elegans. Development 126:1055-64 |
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| Abstract |
Mutations in the C. elegans gene egl-27 cause defects in cell polarity and cell migration: the polarity of the asymmetric T cell division is disrupted and the descendants of the migratory QL neuroblast migrate incorrectly because they fail to express the Hox gene mab-5. Both of these processes are known to be controlled by Wnt pathways. Mosaic analysis indicates that egl-27 function is required in the T cell for proper cell polarity. We cloned egl-27 and discovered that a domain of the predicted EGL-27 protein has similarity to Mta1, a mammalian factor overexpressed in metastatic cells. Overlaps in the phenotypes of egl-27 and Wnt pathway mutants suggest that the EGL-27 protein interacts with Wnt signaling pathways in C. elegans. |
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| Keywords |
Amino Acid Sequence; Animals; Animals, Genetically Modified; Base Sequence; Caenorhabditis elegans/embryology; Caenorhabditis elegans Proteins; Cell Movement; Cell Polarity; Cloning, Molecular; DNA, Complementary; DNA-Binding Proteins; Gene Expression Regulation, Developmental; Helminth Proteins/genetics; Helminth Proteins/physiology; Histone Deacetylases; Humans; Molecular Sequence Data; Proteins/genetics; RNA, Messenger; Rats; Repressor Proteins; Sequence Homology, Amino Acid; T-Lymphocytes; Transcription Factors |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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