PMID:9861059

Citation	Boyes, DC, Nam, J and Dangl, JL (1998) The Arabidopsis thaliana RPM1 disease resistance gene product is a peripheral plasma membrane protein that is degraded coincident with the hypersensitive response. Proc. Natl. Acad. Sci. U.S.A. 95:15849-54
Abstract	Disease resistance in plants is often controlled by a gene-for-gene mechanism in which avirulence (avr) gene products encoded by pathogens are specifically recognized, either directly or indirectly, by plant disease resistance (R) gene products. Members of the NBS-LRR class of R genes encode proteins containing a putative nucleotide binding site (NBS) and carboxyl-terminal leucine-rich repeats (LRRs). Generally, NBS-LRR proteins do not contain predicted transmembrane segments or signal peptides, suggesting they are soluble cytoplasmic proteins. RPM1 is an NBS-LRR protein from Arabidopsis thaliana that confers resistance to Pseudomonas syringae expressing either avrRpm1 or avrB. RPM1 protein was localized by using an epitope tag. In contrast to previous suggestions, RPM1 is a peripheral membrane protein that likely resides on the cytoplasmic face of the plasma membrane. Furthermore, RPM1 is degraded coincident with the onset of the hypersensitive response, suggesting a negative feedback loop controlling the extent of cell death and overall resistance response at the site of infection.
Links	PubMed PMC28133
Keywords	Arabidopsis/genetics; Arabidopsis/microbiology; Arabidopsis Proteins; Cell Membrane/metabolism; Cytoplasm/metabolism; Genetic Vectors; Immunity, Innate; Kinetics; Membrane Proteins/genetics; Plant Proteins/genetics; Plant Proteins/metabolism; Pseudomonas/pathogenicity; Recombinant Fusion Proteins/biosynthesis; Recombinant Fusion Proteins/metabolism; Transformation, Genetic
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Gene product	Qualifier	GO ID	GO term name	Evidence Code	with/from	Aspect	Notes	Status
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